Objective Application of the large number of data sources of hospital management system to optimize the hospital infection management system and to provide the sufficient evidence on the clinical diagnosis , and to simplify the report process and improve the compliance and qualified rate , and to enhance the working efficiency of infection management .Methods The requirements were made by the department of infection management .Then the information department constructed and optimized the infection management system.The incidence of fail-reported infection cases and the compliance and qualified rate were compared . Results The compliance rate of infection cases increased from 56.0% to 71.1%, and the compliance rate of multiple resistant bacteria infection cases increased from 49.4% to 64.0%.The differences were significant (χ2 =6.414 68, 6.157 08, respectively, P <0.05).The qualified rate of infection cases increased from 61.4%to 84.8%, and the qualified rate of multiple resistant bacteria infection cases increased from 56.3%to 86.3%.The differences were significant (χ2 =12.251 70, 14.173 90, respectively;P<0.05).The incidence of fail-reported infection cases decreased from 4.0% to 1.7%, and the incidence of fail-reported multiple resistant bacteria infection cases decreased from 30.1% to 18.3%.The differences were significant (χ2 =5.422 54, 11.610 10, respectively;P<0.05).Conclusions Optimized hospital infection management system can make the medical staff achieve resource sharing .It is convenient to operate and improves the compliance and the qualified report . The optimized infection management system achieves the real-time, dynamic and comprehensive management of the infection cases and multiple resistant bacteria infection cases , as well as improving the efficiency of the department of infection management .