Objective To investigate knowledge, attitude and practice (KAP) on schistosomiasis control in transmission-interrupted areas in order to provide basis for making out intervention strategies of preventing re-epidemic of schistosomiasis. Methods A questionnaire survey was carried out for residents’ KAP on schistosomiasis control in the transmission-interrupted areas. A total of 608 residents were surveyed. Results The residents’ understanding rates of each item of schistosomiasis control were under 25.00% without exception. Residents refusing schistosomiasis examination, never surveying snails and never reporting snails accounted for 52.30%, 95.23% and 97.86% respectively. Conclusions Residents treat schistosomiasis control with indifference in transmission-interrupted areas. Therefore, intervention strategies of pertinent health education should be adopted to improve residents’ compliance to schistosomiasis examination and snail survey and report, and to prevent schistosomiasis re-epidemic.