Objective To investigate zhisouhuatan capsule combined with levofloxacin in the treatment of patients with acute exacerbation of chronic bronchitis.MethodsRetrospective analysis was used to analysis the clinical data of patients with acute exacerbations of chronic bronchitis treated in our hospital from February 2015 to December 2016,according to the treatment methods, which were divided into levofloxacin treatment group and zhisouhuatan capsule combined with levofloxacin in the treatment group.After 4 weeks treatment, the symptom scores, lung function, inflammatory cytokine levels and side effects of the two groups were observed before and after treatment.ResultsThe symptom score of the two groups of patients before treatment had no difference, after treatment, the cough, expectoration and lung auscultation score of combined treatment group were lower than levofloxacin group (t=9.039, 3.574, 7.962, P<0.001);There was no difference between the two groups before treatment.After treatment, the levels of FEV1, FEV1/FVC, MMEF, PEF and FVC in the combined treatment group were higher than that in the levofloxacin group;There was no difference in serum inflammatory cytokine levels between the two groups before treatment.After treatment, the levels of IL-8, hs-CRP and TNF-in the combined treatment group were lower than that in the levofloxacin group (t=25.301, 3.615, 5.733, P<0.001);After 4 weeks of treatment, the blood and urine test results showed that the two groups of patients were not out of liver and kidney dysfunction, with good safety.ConclusionZhisouhuatan capsule combined with levofloxacin on acute exacerbation of chronic bronchitis has good curative effect, can significantly improve symptoms and pulmonary function of patients, with clinical application value.

Objective: To study the related factors of heart failure in patients with non-valvular atrial fibrillation. Methods: Eighty patients with non-valvular atrial fibrillation were selected from the First People′s Hospital of Wucheng District of Jinhua City from August 2015 to April 2019. Patients with atrial fibrillation were divided into non-heart failure group (56 patients) and heart failure group (24 patients) according to the presence or absence of heart failure. The general characteristics of the two groups were compared with univariate analysis and Logistic analysis. Results: There was no significant difference in average age, sex, body mass index, hypertension, hypercholesterolemia, diabetes mellitus, coronary heart disease, stroke, hemoglobin, white blood cell and red blood cell volume between the two groups (P>0.05). There were significant differences in the classification of atrial fibrillation, red blood cell distribution width (RDW) and serum creatinine (P<0.05).Multivariate Logistic regression analysis showed that RDW and serum creatinine were independent predictors of heart failure in patients with non-valvular atrial fibrillation (OR=3.08 and 1.03, P<0.05). The probability of heart failure in persistent atrial fibrillation, long-term persistent atrial fibrillation or permanent atrial fibrillation was 3.87 and 4.10 times higher than that of paroxysmal atrial fibrillation (P<0.05). Receptor operation character (ROC) curve analysis showed that the maximum Youden index of RDW was 14.00%, and the sensitivity and specificity for predicting heart failure were 55.7% and 87.7%, respectively. Conclusions Classification of atrial fibrillation, RDW and serum creatinine may be independent predictors of heart failure in patients with non-valvular atrial fibrillation. RDW>14.00% has certain value in predicting heart failure in patients with non-valvular atrial fibrillation.