1.Research of ultra-structural pathological changes of nervous, endocrine and immune system in heroin addicts.
Li Hua LI ; Hong YAO ; Yong He ZHAO ; Hua ZHU ; Yu Ming XING ; Zhong Tang FENG ; Run Xiang YANG
Journal of Forensic Medicine 2001;17(3):145-147
OBJECTIVE:
To investigate ultrastructural pathological changes of Heroin-Addicts.
METHODS:
Heroin-Addicts' central nervous system, endocrine system, immune system and reproductive system in 4 cases are observed by using transmission electron microscope(TEM).
RESULTS:
The changes of central nervous system are mitochondrion swelling, crista fragmentation and disappear. Endoplasmic reticulum dilation, nervous fibres and cell organelles reduction; mitochondrion swelling, Partial crista fragmentation and endoplasmic reticulum dilation are also found in endocrine system; Lymphocytes reduction, cytoplasm ingredient reduction and dead lymphocytes increase in immune system; in reproductive system, spermatogenic cells and cell organelles are reduced in the male and follicle disappeared in the female.
CONCLUSION
Ultra-structural pathological changes of heroin-addicts are presented acute, chronic oxygen deficiency degeneration and necrosis.
Central Nervous System/ultrastructure*
;
Endocrine System/ultrastructure*
;
Female
;
Genitalia/ultrastructure*
;
Heroin Dependence/pathology*
;
Humans
;
Immune System/ultrastructure*
;
Male
;
Microscopy, Electron
2.Electron microscopic study on Trichomonas vaginalis adhering to and phagocytizing male genitourinary epithelial cells.
Wenlie CHEN ; Jinfu CHEN ; Xiurong ZHONG ; Xi LIN ; Lianyun CHEN
National Journal of Andrology 2004;10(2):86-89
OBJECTIVETo observe Trichomonas vaginalis (T. vaginalis) adhering to and phagocytizing male genitourinary epithelial cells in order to study the pathogenetic mechanism of male trichomoniasis.
METHODSCultured T. vaginalis bodies were incubated with male genitourinary epithelial cells, and then the ultrastructure was observed with transmission electron microscopy.
RESULTST. vaginalis adhered to epithelial cells like amoeba, and formed pseudopodium or surface invagination surrounding or nibbling other parts of the epithelial cytoplasm.
CONCLUSIONST. vaginalis has the speciality of adhering to and phagocytizing to male genitourinary epithelial cells. Genitourinary epithelial cells may be injured directly by the phagocytosis of T. vaginalis. Attention has to be paid to the correlation.
Animals ; Bacterial Adhesion ; Epithelial Cells ; parasitology ; Genitalia, Male ; parasitology ; Humans ; Male ; Microscopy, Electron ; Trichomonas vaginalis ; ultrastructure
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