AIMTo study the clinical features of male genital schwannoma.

METHODSFive male patients with genital schwannoma admitted from 1991 to 2000 were reviewed. The lesions were located in the prostate, spermatic cord, testis or penis. Tumors were simply resected in 3 patients and radically eradicated in 2.

RESULTSThe average age of the cohort was 37 years. The most common sign at presentation was a palpable genital mass accidentally discovered by the patient or detected by the physician during a physical check. Diagnosis was made through postoperative pathological examination. Follow-up ranged from 2 years to 6 years (mean 4.5 years). Four cases were cured by simple excision and 1 patient with malignant testis schwannoma died of recurrence 1 year after surgery.

CONCLUSIONOwing to the lack of characteristic clinical manifestation, the final diagnosis relies on postoperative pathological examination. S-100 and vimentin are useful markers for the diagnosis of these tumors.

Adult ; Aged ; Genital Neoplasms, Male ; diagnosis ; pathology ; Humans ; Male ; Middle Aged ; Neurilemmoma ; diagnosis ; pathology ; Penile Neoplasms ; diagnosis ; pathology ; Prostatic Neoplasms ; diagnosis ; pathology ; Testicular Neoplasms ; diagnosis ; pathology

No abstract available.
Sertoli-Leydig Cell Tumor*

No abstract available.
Sertoli-Leydig Cell Tumor*

No abstract available.
Sertoli-Leydig Cell Tumor*

No abstract available.
Sertoli-Leydig Cell Tumor*

A Sertoli-Leydig cell tumor (SLCT) is an extremely rare type of sex cord stromal tumor of the ovary, which mainly secretes testosterone, thus manifestations of hyperandrogenism commonly appear. This paper shall discuss a case of a postmenopausal woman who presented with pelvic organ prolapse, large left ovarian cyst and mild signs of hyperandrogenism. She underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy, which on microscopic examination of the specimens, revealed a Mature cystic teratoma on the left ovary and an incidental finding of a well-differentiated SLCT, on the grossly normal-looking ovary. This histopathologic diagnosis of SLCT explained the patient’s hyperandrogenic characteristics. Authors likewise discussed the proper management of SLCT, including immunostaining and need for adjuvant chemotherapy.
Sertoli-Leydig Cell Tumor

Some sexual differentiation disorders are associated with gonadal neoplasia and increased incidence of testicular tumors has been discribed in the patients with, XY gonadal dysgenesis. The incidence of testicular tumors in infants and children are rare, representing only 1% of all pediatric solid tumors. In general, gonadal stromal tumors are one of the most characteristic endocrine tumors of the testis, endocrine activity occurs in at least 10-20%, among them Leydig cell tumors and Sertoli cell tumors are clinically important. Although the exact pathogenesis is unknown, endocrine activity due to estrogen secretion can be manifested clinically with gynecomastia or precocious puberty. We experienced and reported a child who visited for sexual precocity and had XY gonadal dysgenesis with Sertoli cell tumor.
Child ; Disorders of Sex Development ; Estrogens ; Gonadal Dysgenesis ; Gonads ; Gynecomastia ; Humans ; Incidence ; Infant ; Leydig Cell Tumor ; Male ; Puberty, Precocious ; Sertoli Cell Tumor* ; Testicular Neoplasms ; Testis

No abstract available.
Puberty, Precocious* ; Sertoli-Leydig Cell Tumor*

OBJECTIVETo study the causes of orchiectomy in different age groups.

METHODSWe retrospectively reviewed the clinical data about 291 cases of orchiectomy performed between March 1993 and October 2014 and analyzed the causes of surgery and their distribution in different age groups.

RESULTSThe main causes of orchiectomy were testicular torsion (45.8%), cryptorchidism (32.5%) and testicular tumor (16.9%) in the patients aged 0-25 years, testicular tumor (42.4%), cryptorchidism (25.9%) and tuberculosis (10.6%) in those aged 26-50 years. Prostate cancer was the leading cause in those aged 51-75 years (77.6%) or older (84.0%)), and testicular tumor was another cause in the 51-75 years old men (10.2%). Prostate cancer, testicular tumor, cryptorchidism, and testicular torsion were the first four causes of orchiectomy between 1993 and 2009. From 2010 to 2014, however, testicular tumor rose to the top while prostate cancer dropped to the fourth place.

CONCLUSIONThe causes of orchiectomy vary in different age groups. The proportion of castration for prostate cancer patients significantly reduced in the past five years, which might be attributed to the improvement of comprehensive health care service.

Adolescent ; Adult ; Age Factors ; Aged ; Causality ; Child ; Child, Preschool ; Cryptorchidism ; surgery ; Humans ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Orchiectomy ; statistics & numerical data ; Prostatic Neoplasms ; surgery ; Retrospective Studies ; Spermatic Cord Torsion ; surgery ; Testicular Neoplasms ; surgery ; Tuberculosis, Male Genital ; surgery ; Young Adult

Sertoli-Leydig cell tumor is a rare sex-cord stromal tumor of the ovary and accounts for less than 0.5% of all ovarian tumors. It is among the most fascinating from pathologic and clinical viewpoints in masculinization. We experience an unusual case of a poorly differentiated Sertoli-Leydig cell tumor in 60-year-old woman who showed masculinization and present it with brief review of literature.
Female ; Humans ; Middle Aged ; Ovary* ; Sertoli-Leydig Cell Tumor*