1.Evaluation of Salt Processing on Pharmacokinetics of Geniposidic Acid in Eucommia ulmoides Oliver
Qianqian GAO ; Zebin WENG ; Genhua ZHAO ; Cuiping YAN ; Zhipeng CHEN ; Baochang CAI ; Han XU ; Weidong LI
Journal of Nanjing University of Traditional Chinese Medicine 2015;(5):453-456
ABSTRACTOBJECTIVE To establish UHPLC?MS/MS method to determine geniposidic acid in rat plasma and to investigate the effect of salt processing on pharmacokinetics of geniposidic acid in Eucommia ulmoides Oliver.METHODS Chromato-graphic columnBEH?C18100 mm×2.1 mm1.7 μmthe mobile phaseacetonitrile?0.1% formic acid aqueous solution. The gradient elution program was performed at a flow rate of 0.3 mL/min.RESULTS The main pharmacokinetic parameters of geniposidic acid in raw and salt products were thatAUC0?t were1 47.18±272.282 120.694± 664.532ng.h/mLAUC0?∞ were1 564.42±273.972 145.61 ±659.983ng.h/mLCmax were517.59±51.24733.292±261.34ng/mLMRT were2.68±0.112.551±0.08hT1/2 were1.37±0.081.43±0.17hTmax were1.52±0.11.51± 0.1h.CONCLUSION Salt processing can obviously enhance the absorption of geniposidic acid in Eucommia ulmoides Oliverand increase the bioavailability.
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