Objective To investigate the application of serum NT-PROBNP and cTn level detection in senior acute coronary syndrome(ACS) patients during PCI perioperative.Methods 67 ACS patients who need PCI treatment in the Second People’s Hospital of Liaocheng from April 2013 to April 2014 were selected and their perioperative serum NT-PROBNP and cTn levels were detected.At the same time,30 healthy senior people were chosed as control and their serum NT-PROBNP and cTn levels were also detected.Perioperative serum NT-PROBNP and cTn levels between ACS patients and heathy people were compared,the relationship between serum NT-PROBNP,cTn level and cardiac function of ACS patients were analyzed,and the ROC curve was used to analyze the predictive value of serum NT-PROBNP and cTn joint detection on cardiac function in ACS patients. Results Serum cTnT,cTnI and NT-PROBNP levels of ACS patients were higher than that of healthy senior people (P<0.05 ).Serum cTnT,cTnI and NT-PROBNP levels of ACS patients in postoperative 4h,12h and 24h were higher than that of preoperative,and serum cTnT,cTnI and NT-PROBNP levels in postoperative 72 were lowered,and the differences were statistically significant(P<0.05 ).Pearson correlation analysis results showed that serum cTnT, cTnI and NT-PROBNP levels and heart function of senior ACS patients were negatively correlated (rcTnT=-0.706,rcTnI =-0.841,rNT-PROBNP =-0.822, P<0.05).Area under the ROC curve was 0.678 to 0.945,which belongs to 0.6 -0.9,serum NT-PROBNP and cTn joint detection could well predict the heart function of senior ACS patients.Conclusion Serum cTnT,cTnI and NT-PROBNP levels and heart function of senior ACS patients are negatively correlated.Serum NT-PROBNP and cTn joint detection can be used as predictor of cardiac function of senior ACS patients treated with PCI.