1.Progress on Molecular Biology for Forensic Ancestry Inference.
Journal of Forensic Medicine 2018;34(3):286-293
Forensic ancestry inference refers to the application of ancestry inference of population genetics in forensic practice, which aims to assist police investigation and judicial trial. With the rapid development and extensive use of genomics, DNA as a direct carrier of genetic information, has soon replaced various phenotypic markers and become the main research topics of forensic ancestry inference. This paper reviews different kinds of genetic markers used for forensic ancestry inference, the statistical analysis methods applied, and the prospects of the development in this field.
DNA
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Forensic Genetics
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Genetic Markers
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Genetics, Population/trends*
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Humans
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Molecular Biology/trends*
2.Genome-wide association studies on prostate cancer: the end or the beginning?
Rui CHEN ; Shancheng REN ; Yinghao SUN
Protein & Cell 2013;4(9):677-686
Prostate cancer (PCa) is the second most frequently diagnosed malignancy in men. Genome-wide association studies (GWAS) has been highly successful in discovering susceptibility loci for prostate cancer. Currently, more than twenty GWAS have identified more than fifty common variants associated with susceptibility with PCa. Yet with the increase in loci, voices from the scientific society are calling for more. In this review, we summarize current findings, discuss the common problems troubling current studies and shed light upon possible breakthroughs in the future. GWAS is the beginning of something wonderful. Although we are quite near the end of the beginning, post-GWAS studies are just taking off and future studies are needed extensively. It is believed that in the future GWAS information will be helpful to build a comprehensive system intergraded with PCa prevention, diagnosis, molecular classification, personalized therapy.
Continental Population Groups
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genetics
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Genetic Predisposition to Disease
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Genome-Wide Association Study
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trends
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Humans
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Male
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Polymorphism, Single Nucleotide
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Prostatic Neoplasms
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genetics