No abstract available.
Genetic Predisposition to Disease*

Crohn's disease (CD) is a chronic inflammatory disorder affecting any part of the digestive tract which relapses and remits throughout the disease course. It occurs in individuals with genetic susceptibility and involves an abnormal response of the immune system to the external environment. Besides, improved hygiene, abuse of antibiotics, westernization of diet with high sugar and fat are thought to be associated with rapidly increasing incidence of CD. Certain components of foods may influence gut inflammation through antigen presentation and alteration of the microflora. This article aims mainly to review diet-related clinical studies to outline its roles in the pathogenesis and progress of disease, and then give some evidence-based suggestions.
Crohn Disease ; Diet ; Genetic Predisposition to Disease ; Humans

No abstract available.
Breast Neoplasms* ; Breast* ; Genetic Predisposition to Disease* ; Korea*

No abstract available.
Genetic Predisposition to Disease* ; Lung Neoplasms* ; Lung*

Genetic Predisposition to Disease ; Humans ; Tuberculosis ; genetics

OBJECTIVES: The purpose of this study is to compare the ability of facial affect perception among schizophrenia patients, their first degree relatives, and normal control subjects. METHODS: Thirty five patients with schizophrenia, 22 first degree relatives, and 34 normal control subjects were recruited in this study. All three groups were matched for age and education levels. The facial affect identification test(FAIT), and neurocognitive test were applied. In the FAIT, the correct response rate, perceived intensity, and sensitivity for 6 kinds of affects were compared among three groups. RESULTS: We found that correct response rate of sadness and anger were decreased in the schizophrenia patients compared with the normal control group. Also the schizophrenia patients showed reduced sensitivity for all six affects compared with the normal control group. The ability of facial affect perception in first degree relatives of schizophrenia patients was decreased but there were not any significant differences compared with normal control group. CONCLUSION: This study confirmed significantly reduced ability of facial affect perception in schizophrenia patients compared with normal control. Decreased ability of facial affect perception in first degree relatives suggests that affective sensitivity can be influenced by genetic predisposition.
Anger ; Genetic Predisposition to Disease ; Humans ; Schizophrenia

Genetic Predisposition to Disease ; Humans ; Mutation ; Polymorphism, Genetic ; Precision Medicine

Caspases ; genetics ; Genetic Predisposition to Disease ; Humans ; Neoplasms ; genetics ; Polymorphism, Genetic

Essential hypertension (EH) is a complex multifactorial disorder with genetic and environmental factors contributing to its prevalence. The genetic features have been revealed from the significant familial aggregation and the consistency among twins. Therefore, identification of EH susceptibility genes will be helpful to understand the pathophysiology of the disease, identify populations with potential risks of developing the disease, and select antihypertensive drugs. The present article introduces the search strategies of EH susceptibility genes and some genetic variants related to EH; meanwhile, it tries to analyze the difficulties and the role for samples in identifying susceptibility genes to EH.
Genetic Predisposition to Disease ; genetics ; Genetic Testing ; methods ; Genetic Variation ; Humans ; Hypertension ; genetics ; Polymorphism, Genetic ; Research Design

The etiology of chronic pancreatitis varies greatly as demonstrated in the TIGAR-O classification. However, due to the lack of correlation and reproducibility between the etiologic factors and the presentation of the disease, it is presumed that individual sensitivity such as genetic predisposition would play an important role in its pathogenesis. Although our understanding on the pathophysiology of chronic pancreatitis is still far from being adequate, we are gaining more insights on its underlying mechanism through active researches related to pancreatic stellate cells, and molecular/genetic studies. Since the clinical manifestations of chronic pancreatitis show significant variation according to its cause, stages of the disease, and presence of local complications, controversy still remains regarding the natural course of chronic pancreatitis and warrants further study. At present, it is generally agreed that acute pancreatitis, recurrent acute pancreatitis, and chronic pancreatitis lie on the same spectrum of the disease.
Genetic Predisposition to Disease ; Pancreatic Stellate Cells ; Pancreatitis ; Pancreatitis, Chronic