OBJECTIVE: To evaluate the value as well as correlation between blood drug level and blood routine results in patients using cyclospone A (CsA) following renal transplantation via analyzing varies of immunosuppressive agents used in renal transplantation. METHODS: Retrieval-related contents were collected by computer from Chinese Journal Full-Text Database with of "renal transplantation, CsA, and therapeutic drug monitoring". Simultaneously, data of patients who received CsA treatment after renal transplantation in the Department of Laboratory, Liaoning Provincial Electrical Hospital were selected. All the literature was retried and analyzed. RESULTS: A total of 717 patients were included in the final analysis. It demonstrated that 6 sorts of immunosuppressive agents, such as mizoribine, sirolimus, zenapax, mycophenolate, and basiliximab play an important role in immune suppression after organ transplantation. However, there still exist problems need to be further explored. CsA was more suitable for clinical application with lower price and good curative effect, which worked better combined with other immunosuppressive agents. CONCLUSION: A best curative effect of CsA can be achieved by timely adjusting therapeutic regimen under the patient's condition. Meantime, a high efficiency and low toxicity drug with specific tolerance is the ultimate goal of immunosuppressive agents.

Acute myeloid leukemia (AML) is a highly heterogenous disease with multiple signaling pathways contributing to its pathogenesis.A key driver of AML is the mutation of FMS-like tyrosine kinase receptor-3 (FLT3) gene.Mutations in FLT3,primarily the FLT3-internal tandem duplication (FLT3-ITD),are associated with decreased progression-free and overall survival.Due to the importance of FLT3-ITD and its pathway in the prognosis of patients with AML,it has stimulated efforts to develop therapeutic inhibitors of FLT3.Although the FLT3 inhibitors show a certain degree of antileukemia activity,their clinical effect has some limitations as a single drug.Now,Quizartinib (AC220) is the potent second generation FLT3 selective inhibitors.Based on the resistance mechanism for FLT3 inhibitom,more and more scholars has been studying the inhibition of FLT3-ITD+ cell lines and primary leukemia cells by AC220 alone and in combination with cytotoxic chemotherapies/protein kinase inhibitors as well.However,the clinical effects of a variety of combination plan remain to be further investigated.

In order to adapt to the changes of medicine mode and market needs, the Nursing Department of Fujian TCM gave an elective course of nursing etiquette, and made teaching designs for the course, including the designs of teachers training, teaching objects, teaching contents and teaching methods. At the end of the course, the authors conducted questionaire, interview and examination among the students, and analyzed the data by statistical methods, and believed that the result was good. Besides, the article discussed the meaning of setting the Nursing etiquette course, and gave some suggestions on the course building.

Taking the basic theory of Chinese medicine as the instruction, through the bidirectional features of clinical manifestations, the relative etiology and pathology, acupoints and treatments, the bifunctional law in acupuncture theory is discussed. And it is held that after the confirmation of bidirectional symptoms of some diseases or syndromes, acupoints which have special functions in the bifunctional theory of acupuncture with a narrow meaning can be taken as major acupoints. And at the same time, other proper acupoints and flexible treating methods can be selected under the instruction of the bifunctional law of the broad meaning, so as to get the best therapeutic effect.
Acupuncture Points ; Acupuncture Therapy ; Humans ; Medicine in Literature ; Meridians

Child ; Dental Occlusion ; Humans ; Tooth Eruption

On the basis of related literature, this paper analyzed that the traditional Chinese medicine combinated with chemotherapy can improve the clinical effect of middle-late phrase gastric cancer patients and improve their quality of life, reduce adverse reaction of chemotherapy, prolong survival period.

Objective: To compare the safety and efifcacy of rivaroxaban and warfarin for treating the patients with left ventricular thrombus. Methods: A total of 31 patients with left ventricular thrombus were studied, the patients were randomly divided into 2 groups:Warfarin group, n=16, the patients initially received oral warfarin and low molecular weight heparin at (2.5-3) mg/day, when the INR value reached 2.0-3.0, heparin was stopped and warfarin was continued, the INR value was monitored every 3 days for 3 times, when INR value was stably kept at 2.0-3.0, it was then monitored for every 2 weeks. Rivaroxaban group,n=15, the patients received oral rivaroxaban at 10 mg twice a day. All patients were followed-up for 3 months, the thrombus remission time, new onset of thrombosis, embolism and bleeding events during treatment period were compared between 2 groups. Results: The patients’ age, gender, complication, size of thrombus and medication were similar between 2 groups. Compared with Warfarin group, Rivaroxaban group had the shorter thrombus remission time, (60.00±5.50)d vs (71.00±8.50) d,P<0.01, while the new onset of thrombosis and embolism events as cerebral embolism and systemic embolism were similar between 2 groups, Warfarin group had slightly higher bleeding events, allP>0.05. Conclusion: Rivaroxaban had better effect than warfarin for treating the patients with left ventricular thrombus without increasing the risk of bleeding.

Autogenous vein graft is one of the frequent methods to treat ischemia in Vascular Surgery.However, the patency rate of vein grafts is unhappy because of the injury, the difference structure between arteries and veins, and the change of hemedynamics after grafted. The restenosis of vein graft contains three syntrophic component elements-thrombosis, intima hyperplasia, and scleratheroma. In this article, we will discuss the relationship between the changed hemodynamics and the restenosis of the vein grafts.

Objective To explore the role of claudin-3, claudin-4 in carcinogenesis and progression of ovarian mucous cystoadenocarcinoma. Methods Immunohistochemical and in situ hybridization method were employed to detect the expression of claudin-3, -4, claudin-4 mRNA in ovary epithelium, mucinous cystadeno-nut, mucinous cystadenoma of borderline, mucous cystadenocarcinoma. Results claudin-3, -4 expression was lowest in ovarian epithelium and mucinous cystadenoma, higher in borderline mucinous cystadenoma, and high-est in ovarian cystadenocarcinoma(P<0.05 ). The expression of claudin-3, -4 in poor differentiated ovarian carcinoma was stronger than that in well- differentiated and moderately differentiated carcinoma (P< 0.05 ),but there was no significant difference between well-differentiated and moderately differentiated carcinoma(P>0.05). Conclusion The overexpvession of claudin-3, -4 is correlated closely with the carcinogenesis and advancement of ovarian mucinous carcinoma, and may have correlation with the differentiated degree of o-varian carcinoma, claudin-3, -4 may become the specific markers of ovarian mucous cystadenocarcinoma.

BACKGROUND: Routine magnetic resonance imaging(MRI)scans can comparatively show intra-articular soft tissue structures,but there are still some limitations in the diagnosis of intra-articular lesions and injury due to deficiency in contrast of imaging.Enhanced MRI scan has been applied to the liver,brain and other parts,which effectively improves the diagnostic accuracy,but there are few reports on the enhanced scans of knee.OBJECTIVE: To evaluate clinical application value of MRI enhancement pattern in diagnosis of knee injury.METHODS: Totally 21 patients with knee injury(22 knees)were routinely scanned by 0.5T Signa Contour MRI scanner(GE company,USA).Then enhancer was injected into knee joint by the same physician and MRI enhancement pattern was performed in these patients.Film-reading and comparison were completed by two associate chief physicians.RESULTS AND CONCLUSION: Different levels of joint structural damage,such as bone,meniscus,ligaments,and articular cartilage and so on,were found in all patients by routine MRI scan.The extent and scope of its damage had been more clearly displayed by enhanced MRI scan.Meanwhile,misdiagnosis of meniscal injury by routine MRI scan was confirmed by enhanced MRI scan in 2 patients.Some damaged parts that were not found by routine MRI scan were Confirmed by enhanced MRI scan.All these demonstrated that positive rate of knee injury in MRI enhancement pattern was higher than conventional MRI scan.There was significant difference in meniscus injury between two patterns(P = 0.035).MRI enhancement pattern in comparison with conventional MRI can further improve the diagnostic accuracy rate of knee injury.