AIM　To study protective effect of taurine on diaphragm against adriamycim cytotoxity in rabbits.METHODS　The rabbits were divided randomly into three groups.①Control group:The animals were administered NS 2 ml*kg-1 for five days. ②Adriamycin+NS group:The animals were administered NS 2ml*kg-1 for five days and then administered adriamycin 10 mg*kg-1.③Adriamycin+taurine group:The animals were administered taurine 100 mg*kg-1 for five days and then administered adriamycin 10 mg*kg-1.After 24 h,three groups animals were anaesthetized.The transdiaphragmatic pressure(Pdi) and diaphragm evoked potential(DEP) were measured.SOD and MDA were tested.the ultrastructure of diaphragm cells was investigated by eletronmicroscopy.RESULTS　The Pdi and amplitude of DEP were lowered by adriamycin(P＜0.01).The levels of MDA was increased and the activity of SOD was decreased in diaphragm(P＜0.05).The disorder of myofibrills,swelling of mitochondria with broken cristase can be observed by electronmicroscopy.The above changes were inhibited by taurine.CONCLUSIONS　The taurine could scavenge the toxic radicals generated by adriamycin and protect the diaphragm myocytes.

AIM To study protective effect of taurine on diaphragm against adriamycim cytotoxity in rabbits. METHODS The rabbits were divided randomly into three groups. groups group: The animals were administered NS 2 ml.kg- 1 for five days. ②Adriamycin + NS group: The animals were administered NS 2ml. kg-1 for five days and then administered adriamycin 10 mg. kg- 1. ③Adriamycin + taurine group: The animals were administered taurine 100 mg. kg-1 for five days and then administered adriamycin 10 mg?kg- 1. After 24 h, three groups animals were anaesthetized. The transdiaphragmatic pressure(Pdi) and diaphragm evoked potential(DEP) were measured. an and MDA were tested. the ultrastructure of diaphragm cells was investigated by eletronmicroscopy. RESULTS The Pdi and amplitude of DEP were lowered by adriamrcin(P

To study the protective effect of Shengmai Injection on adriamycin-induced cytotoxity of diaphragm in rabbits. The rabbits were randomly allocated to three groups. The control group were treated with NS 2 ml?kg -1 for five days, adriamycin+NS group with NS 2ml?kg -1 for five days and then administered adriamycin 10 mg?kg -l and adriamycin + Shengmai Injection group with Shengmi Injection 2 ml?kg -l for five days and then administered adriamycin 10 mg?kg -1 . Twenty-four hours later, animals in the three groups were anaesthetized. Then the transdiaphragmatic pressure (Pdi) and diaphragm evoked potential(DEP) were measured, SOD activity and MDA content were tested and the ultrastructure of diaphragm cells was observed under electron microscope. Adriamycin could lower the Pdi and amplitude of DEP (P

Objective To understand the testing capability for organochlorine pesticides of the food inspection labs in China. Methods The CNCA organized the proficiency testing(PT) of determination of heptachlor, aldrin and dieldrin in the vegetable oils. 21 labs from 14 provinces (cities) took part in the PT. The GC method prescribed by official method of AOAC was recommended, other method was also permitted. Results The PT showed that 81.0%-85.7% labs presented satisfactory results, 9.5% had questionable results and 4.8%-9.5% had dissatisfactory results. Conclusion Most of the labs that took part in the PT have good competence in analyzing organochlorine pesticides.

Objective To explore the clinical value of 3-dimensional CT angiographic (3D-CTA) imaging of vertebral artery. Methods Volume rendering (VR) and shaded surface display (SSD) of 3D-CTA were adopted to examine 67 patients whose primary clinical diagnosis was vertebral artery insufficiency. Among them, 7 were examined with selective vertebral artery angiography.Results One hundred and thirty-three vertebral arteries (52 normal ones and 81 with lesions) were displayed and the rest one was not displayed due to complete occlusion. The lesions consisted of congenital abnormities, compression or displacements caused by traction, rough vascular surface, calcification, lumen stenosis, partial occlusion etc.. The vertebral arteries with developmental abnormities could be complicated with various other lesions, also the lesions might occur on multiple sections of a single vertebral artery; the description was as follows: there were 31 vertebral arteries with congenital abnormities (17 with developmental thinness and 14 with abnormally extended courses); 11 with lesions on initial sections (V1) (10 with roughened vascular surfaces and thin diameter, among which 3 were twisted in an anglular shape and 1 was calcified ); 30 with lesions (13 with the displacements caused by hyperosteogeny compression, 7 with internal displacements caused by traction, 10 with local lesions) on cervical vertebrae sections (V2) and atlanto-occipital section (V3); 55 with lesions (52 with beaded shapes and coarse walls, among which 2 had calcification and 3 partially blocked ) on intracranial sections (V4). Thirteen lesions on 8 abnormal blood vessels out of the 14 blood vessels of 7 patients, who were examined with the selective vertebral artery angiography, had lesions including stenoses displayed as significant by 3D-CTA but displayed as mild by DSA on 2 intracranial sections, and the examining results of 3D-CTA conform to those of DSA for lesions on other 11 sections. Conclusion 3D-CTA can distinctly display the whole course of the vertebral arteries and show its anatomical relationships with vertebrae. 3D-CTA is superior to other angiographic method to display congenital abnormalities and/or calcification of the vertebral arteries and assess the status of vertebral bones. It provides important information for diagnosis of vertebral artery disease.

Objective: Effects of Shenmai injection and aminophylline alone or in combination on transdiaphragmatic pressure and electrical activity of diaphragm were observed, so as to evaluate their effecfs on diaphragmatic fatigue. Methods: The diaphramatic fatique (DiF) model was estab- lished by stimulating bilateral phrenic nerves for 40 minutes. The animals were allocated to three groups: Shenmai group (2mL/kg, N=7), aminophylline group (20mg/kg, N=7) and combi- nation group (Shenmai injection 2mL/kg+aminophylline 20mg/kg, N=7) The transdi- aphragmatic pressure (Pdi) and diaphragmatic electromyogram (EMGdi) were recorded before and after treatment. EMGdi was analysed by computer and then the high/low frequency ratio (H/L) and the central frequency (Fc) were caculated. The diaphragm evoked potential (DEP) was record- ed simutaneously. All data was analysed by analysis of variance and q test. Results: Pdi, H/L, Fc and amplitude of DEP were markedly increased after the treatment with aminophyline and Shen- mai injection alone (Compared with DiF. P

Objective To explore the misunderstanding and comprehension of hybrid operation for treating aortic dissection involving aortic arch.Methods From March 2009 to November 2013,13 patients received hybrid operation for aortic dissection involving aortic arch in the People's Hospital of Xinjiang Urgur Autonomous Region were enrolled,including male 11 and female 2,and aged 36 ～ 60 years old with a mean age (44 ± 6.8) years old.All patients were type-B aortic dissection.All of them were not suitable to be treated with endovascular exclusion monotherapy.The ascending aorta-brachiocephalic artery bypass and left carotid artery bypass was established with median sternotomy approach and neck incision in 13 patients,and 2 patients did left subclavian artery bypass additionally,then retrograde endovascular stent graft implantation was used.Computed tomography angiography (CTA) scanning at 3-month,9-month,1-year and every-year after operation showed no stent grafts translocation and bypass graft obstruction.Results The surgical operation and stent grafts implantation were completely successful.Angiography showed 1 case had end leakage and other cases no obvious displacement or end leakage of stent grafts in operation.Blood flow in true lumen of aortic dissection was recovered and all of bypass grafts were unobstructed.No death and severe complications occurred.All patients were followed-up with 3 to 56 months [(29.0 ± 10.2) months],and all patients resumed normal life.Enhanced CT scanning after operation showed 1 case had endoleak and other cases no endoleak,stent grafts translocation and bypass graft obstmction.No signs of brain and limb ischemia were observed.Conclusions To summarize misunderstanding and experience by continuous explore feature of hybrid operation for treating disease involving aortic arch,we developed a more reasonable surgical treatment options that can improve the success rate of complex aortic dissection surgery,and ultimately achieve better surgical results.

Objective Retrospective analysis of experience of distal upper limb autologous arteriovenous fistula for hemodialysis access and treatment of arteriovenous fistula occlusion was conducted.Methods To summarize the clinical data of 214 cases of initial autologous arteriovenous fistula and 22 cases of treatment of arteriovenous fistula occlusion were carried out from Aug.2007 to Mar.2011,comparing the success rate and long-term patency rate.Results Two hundred and fourteen cases of initial autologous arteriovenous fistula,in which 168 cases were cephalic vein-radial artery side-to-side anastomosis at snuffbox,46 cases were cephalic vein-radial artery end-toside anastomosis at proximal wrist,the success cases were 203 (94.8％),the failed cases were 11 (5.2％),limb edema in 82 cases and there was no steal syndrome and heart failure.The primary patency rate was 95.2％ at 1 year and 91.3％ at 2 years.There were 22 patients accepted treatment of arteriovenous fistula occlusion,in which,8 cases were embolectomy due to acute occlusion,8 cases were thrombectomy and balloon dilation because of anastomotic stricture and thrombosis and 1 failed,5 cases were proximal anastomosis again after chronic occlusion.Conclusions Autologous arteriovenous fistula of the distal upper limb,especially from the place of snuffbox which is the preferred method for autologous arteriovenous fistula.And deal with arteriovenous fistula occlusion actively can often extend the usage time of the autologous blood vessels and improve the life quality of patients.

Objective To evaluate thoracic endovascular aortic repair for type B aortic dissection.Methods Chnical data were reviewed on 126 cases with type B aortic dissection undergoing endovascular aortic repair in our hospital from January 2006 to April 2011.There were 86 male patients and 40 female patients,age from 32 to 82 years.The stent- grafts were introduced via femoral arteriotomy.Stent-grafts were implanted to blockade tears of aortic dissection under the guidance of DSA.Postoperatively patients were followed-up by angiography and imiging for endoleak,stent migration,and fracture of stent-graft.Results In all cases,the aortic dissection tears were closed,true lumens were opened,and organ function was restored.There were not complications such as internal hemorrhage due to trauma or stent displacement on CTA from 3 to 63 months after endovascular therapy.Procedure was successful in all 126 cases,157 stents were released,2 cases died in the perioperative period,1 case died during the followed-up.A breach was found at the end of the stent in 12 cases,endovascular aortic repair redone successfully with a retrograde type A dissection found during follow-up.Conclusions Endovascular aortic repair is safe and effective for patients with Stanford type B aortic dissection with a favorable outcomes.

Objective To explore the distribution characteristics and clinical typing methods in distal crevasses of Stanford B aortic dissection.Methods Review of the cases in the People's Hospital of Xinjiang Urgur Autonomous Region from 2010 January to 2013 June were diagnosis of Stanford type B aortic dissection with computed tomographic angiography data,Observed its distal crevasses distribution and statistical its number,then summarizes the distribution characteristics of the distal crevasses and further put forward a method of clinical typing.Results Refer to 115 cases with Stanford type B aortic dissection computed tomographic angiography data,including 101 cases with distal crevasses (87.83％) and a total of 240 distal crevasses,an average of 2.37 per case.Conclusions The distal crevasses more often appear in the area involving visceral artery,combined with its different in distribution characteristics and processing methods,we put forward the classification method,namely:Type Ⅰ:the distal crevasses are located in the zone of the thoracic artery; Type Ⅱ:the distal crevasses are close to the visceral artery or involvement it; Type Ⅲ:the distal crevasses are lower than the renal artery,not involving the visceral artery; Type Ⅳ:the distal crevasses are located in the zone of the iliac artery.