The following progresses have been recently made on glaucoma in Zhongshan Ophthalmic Center,covering clinical and basic researches on molecular genetics and epidemiology,stem eells,pathogenesis of calcium and adenosine,neuroprotection,etc. New insight has been shown into about 30 papers published in international peer-review(SCI)journals.

RIA of LH and FSH in 437 cases and PRLin 287 cases of secondary amenorrhea were performed. According to the results they can be divided into 5 groups: hypergonadotropic amenorrhea 132 cases (30.2%), hypogonadotropic amenorrhea 44 cases (10.1%), normogonadotropic amenorrhea 40 cases (9.1%), amenorrhra with increased LH/FSH ratio 94 cases (21.5%) and hyperprolactinemic amenorrhea 127 cases of which 117 cases (92.1%) had galactorrhea. The clinical features, laparoscopy findings and results of treatment were presented.

0.05). It is included that these four concentrations of Se do not directly stimulate and inhibit the oxidizing activity of leucocyte.

0.05). The integral values of leucocyte chemiluminescence (cpm/leucocyte)were 7.267?0.855(Group A), 10.324 ?1.026(Group B) and13.061?1.589(Group C) repectively. Statistically there were a very significant difference(p0.05) between Group B and Group C. The results indicated thet Se had no effect on the tatal of leucocytes, a low level of Se decreased the leucophagocytic oxidative activity, but the Complement of Se can increase such activity. The resulte showed some evidence to the pattogenesis and clinical prevention and treatment of Keshan Disease.

The anti-thyrotropin antibody (TSHab) in 29 normal subjects and 58 patients with Graves' disease (GD) with 125I-TSH as tracer. The TSHab indices were 0.85?0.22 in normal subjects, 1.47?0.35 (P0.05) in GD treated by antithyroid drugs. The result of staphylococus aureus Cowan I precipitation test showed that the antibodies binding to TSH belong to IgG. The existance of TSHab in GD suggested that the reaction of idiotype/anti-Jdiotype was involved in autoimmune mechanism of GD.

The result of experimental study of the bladder replacement with the glutaraldehyde-stalized amimia in 10 rabbits is reported. This kind of aminia, as a substitute for the bladder, replaced 1/3 bladder (n=4), 2/3 (n=5) and subtotal bladder (n=1) in rabbits, with observation for 2 weeks (n=4), 5 weeks (n=5), 6 months (n=1) and 30 months (n=1). The result showed that all replacements of the bladders were succesful. The aminia is probably the best biologic material at present for replacement of the bladder

The Bmax and Kd of beta-adrenoceptors in splenie lymphocytes of rats were determined by direct binding of radioligand, ~3H-dihydroalpranolol. Bmax of beta-adrenoceptors was significantly increased on day+1, was peak on day+2 and gradually reduced to control values on day+ 6 after the intraperitoneal injection of 5?10~9SRBC. A positive correlation (r=0. 86) was found between the Bmax of beta-adrtenoceptors on day+1 to+3 and the amount of Ig M in s(?)rum after 72 hours. Both the Bmax of beta-adrenoceptors on day+2 and the amount of Ig M in serum on day+5 were reduced by the intraperitoneal injection of propranolol. In study on antibody response to SRBC.in vitro, Ig M Synthesis in mouse spleen cells was enhanced by norepinephrine (10?mol/L), and blocked by propranolol (1?mol/L). These results indicated that: (1) the immune response to SRBC in vivo up-regulates the density of beta-adrenoceptors in splenic lymphocytes; (2) the up-regulation of Bmax of beta-adrenceptors in splenic lymphocytes may increase its Ig M synthesis;(3) the enhancement of the Ig M antibody response to SRBC in vitro by norepinephrine was mediated by the beta-adrenoceptors.

OBJECTIVE: To explore the materials and selection of esophageal stents, and to discuss the application of covered stants in treating esophageal malignant stenosis.METHODS: CNKI and Medline databases were retrieved by computer for papers published from 1980 to 2009 with search terms of "esophageal carcinoma, esophageal stenosis, esophageal stent, and fabric-covered metallic stent". The language was limited for Chinese and English. A total of 61 iteratures were initial searched by computer, according to inclusive and exclusive criteria, 29 literatures were selected by the first author. Problems including esophageal stent category, material selection, as well as application of covered stents in treating esophageal malignant stenosis were reviewed and summarized.RESULTS: Totally 29 literatures were included in this paper. No concealed allocation or blinding method was described in the literatures. According to preparing materials, the stents could be divided into stainless metal stent, memory metallic stent and polyester plastic stent. As tissue-engineered materials, stents could be assigned into biodegradable polymer matrix stent and non-degradable biodegradable polymers stent. Each material stent possesses distinct advantage and disadvantage. The covered stents could relief esophageal stenosis effectively, interrupt tumor growth, and prevent restenosis. CONCLUSION: As a palliative therapy for treating esophageal malignant stenosis, covered stents can elevate patients' life quality and prolong survival times.

The side effects of cesarean with the increasing rate section began to attract the attention of pediatricians in recent years. Previous studies reported that the incidence of neonatal pnermothorax by full-term cesarean section, especially selective cesarean section, was significantly higher than vaginal birth or non-selective cesarean section. In addition, with an extensive establishment of NICUs in China and widely use of mechanical ventilation, the rate of successful neonatal rescue was improved obviously, but the incidence of pneumothorax was increasing. Studies suggested that the incidence of neonatal iatrogenic pneumothorax was highly relevant with selective cesarean section and mechanical ventilation. The indications for cesarean section and mechanical ventilation should be carefully considered.

Objective To explore the value of the application of hemorheology test in diagnosis and treatment of malignant tumor .Methods A total of 100 patients suffered from malignant tumors selected as study group ,and divided as distant metastasis subgroup and no distant metastasis subgroup ,meanwhile 50 healthy persons were selected into control group .Test results of hemo‐rheology were compared .Results The whole blood viscosity ,erythrocyte aggregation index ,fibrinogen levels in the distant metasta‐sis subgroup were significant higher than those of the no distant metastasis group ,and the hematokrit level was significant lower than that of the no distant metastasis group ,the differences were statistical significant(P< 0 .05) .The parameters of hemorheology in the distant metastasis subgroup were significant different with that of the control group(P< 0 .05) .Except for erythrocyte aggre‐gation index ,other parameters of hemorheology were also significant different with those of the control group(P < 0 .05) .After treatment the whole blood viscosity ,packed cell volume and plasma viscosity had improved significantly comparing with before treatment(P< 0 .05) .Conclusion In the process of diagnosis and treatment of malignant tumors ,test indicators in hemorheology are constantly changing with the progress of the disease ,which has important application value .