Replacement therapy of stem cells transplantation represents a potential treatment for neural retinal diseases.Despite the encouraging results in laboratory,the clinical application of cells replacement therapy is still difficult because the limitation of seed cells,immunologic rejection,oncogenicity and ethical problems,etc.Recent breakthrough in somatic reprogramming provides a promising solution overcoming these obstacles.Further researches on virus-free reprogramming will make the clinical application of stem cell replacement therapy possible.

Glaucoma ; diagnosis ; therapy ; Humans ; Research

Objective To clarify the etiology of pathological nipple discharge.Methods Since 1990,81 patients with pathological niplpie discharge underwent mammary duct incision to identify the lesion.Results 67 patients had intraductal papilloma,5 patients had intraductal papillomatosis,6 patients had duct carcinoma,and 3 patients were not found pathological changes.Conclusions Intraductal papilloma,intraductal papillomatosis,and duct carcinoma might be the exclusive etiology of pathological nipple discharge.

Through intensifying the clinical pathological discussions and clinical pathological dissections,the clinical thinking,iatri- cal responsibility and analytical ability of the medical students have been improved markedly and the abridge function of pathology between basic medicine and clinical medicine has also been reinforced.

Objective To investigate the women during pregnancy because of various reason caused by the impact of diabetes on perinatal outcome.Methods The delivery 24-28 weeks pregnant or first diagnosed more than 28 weeks after the gynecology clinic diagnosis with diabetes in 125 singleton pregnant women and newborns were selected as the research object of study.Except giving birth to the same period 95 cases of normal of diabetes single fetus of pregnant women and their newborn for the control group.The complications of pregnancy and gestational age,birth and neonatal intrauterine nutrition status,mode of delivery,neonatal asphyxia,hypoglycemia and jaundice,case analysis,comparison.Results The two groups in the average age,average number of pregnancy pregnancy and intrauterine nutrition(group GDM,PI =2.717,control group 2.469) and the rate of neonatal asphyxia were not statistically significant(P ＞ 0.05).GDM group of 71 cases of cesarean section,natural childbirth in 54 cases,31 cases of control group difference and 64 cases,very significant differences between the two groups (x2 =12.678,P ＜ 0.01),group GDM,the incidence of neonatal jaundice neonatal hypoglycemia respectively 18.4%,24%,and 7.4% in the control group,there was significant difference compared with 12.6% (x2 =4.500,5.577,all P ＜0.05).Conclusion Gestational diabetes is the important reason which caused by adverse perinatal outcome.

Nutritional therapy constitutes the basis for the integrated treatment of diabetes.It is essential for diabetic dietary management to be an individualized and balanced diet pattern based on total calorie control Carbohydrates is the main dietary ingredient to affect postprandial blood glucose levels.Dietary structure,way of eating,and physical exercise all contribute to the control of postprandial blood glucose levels.

Objective:To evaluate the effects of early administration of dexmedetomidine on benzodiazepine ( BZD) requirements of intensive care unit ( ICU) patients with alcohol withdrawal syndrome ( AWS) .Methods:Totally 60 adult patients with severe AWS were chosen and randomly divided into groups A and group B with 30 patients in each .The patients in group A received benzodiazepine simultaneously with early administration of dexmedetomidine , and those in group B received only benzodiazepine .After the first admin-istration of dexmedetomidine , the 24-h cumulative BZD requirement , stay length in ICU and hospital , condition of mechanical ventila-tion and incidence of hypotension and bradycardia were recorded .Results:The 24-h cumulative BZD requirement in group A was obvi-ously lower than that in group B [(8.6 ±1.2) mg vs (25.6 ±4.9) mg, P<0.05].The number of patients with mechanical ventila-tion in the two groups was similar, while the duration of intubation in group A was less than that in group B [(24.9 3.1) h vs (48.8 6.9) h, P<0.05].Additionally, group A had higher incidence of bradycardia when compared with group B (57% vs 13%, P<0.05).Conclusion:As the adjuvant treatment for alcohol withdrawal syndrome , early administration of dexmedetomidine can notably decrease the benzodiazepine requirement of ICU patients .

Objective To discuss the influence of atorvastatin and rosuvastatin on carotid intima-media thickness(CIMT) of patients after percutaneous coronary intervention (PCI).Methods 142 patients after PCI with CIMT increasing were randomly divided into Lipitor group (n=71) and Crest group (n=71).The Lipitor group was given atorvastatin(20mg) orally once a day.The Crest group was given rosuvastatin(20mg) orally once a day.The changes of low density lipoprotein,high density lipoprotein,liver function and CIMT before and after 12 weeks treat-ment were observed in two groups.Results After treatment for 6 months, the levels of LDL-C, CIMT in Lipitor group were lower than before treatment with statistical difference[(3.37 ±1.20)mmol/L vs (2.0 ±0.29)mmol/L, (1.29 ±0.06)mm vs (0.91 ±0.23)mm](t=4.032,3.523,all P<0.05);the levels of LDL-C,CIMT in Crest group were lower than before treatment with statistical difference[(3.38 ±1.21)mmol/L vs (1.8 ±0.15)mmol/L, (1.30 ±0.16)mm vs (0.81 ±0.15)mm](t=4.700,3.892,all P<0.05).The decreasing degree of LDL-C, CIMT was significantly lower in Crest group than that in Lipitor group with statistical difference( t=3.668,3.002,all P<0.05 ) .The level of HDL -C in Lipitor group was higher than before treatment with statistical difference [(1.01 ±0.36)mmol/L vs (1.10 ±0.31)mmol/L](t=3.801,P<0.05).The level of HDL-C in Crest group was higher than before treatment with statistical difference[(1.03 ±0.32)mmol/L vs (1.15 ±0.35)mmol/L](t =3.722,P<0.05).The decrease degree of HDL-C was significantly higher in Crest group than that in Lipitor group with statistical difference(t=3.568,P<0.05).Conclusion Rosuvastatin has better effect than atorvastatin on the reversal of atherosclerosis process.

Ways of effectively managing and using the scientific papers published by the personnel of an orga- nization so as to contribute to the enhancement of its scientific and technological strength and the level of its medical work are issues to be explored by file managing departments of scientific and medical institutions. On the one hand, the institutions should work out by administrative means various rules and regulations so as to standardize the filing of papers. On the other hand, the filing departments should enhance people's consciousness and initiative in placing their papers on file through excellent management and convenient service so as to bring the filing of scientific papers into a sound cycle. [