Objective To investigate the women during pregnancy because of various reason caused by the impact of diabetes on perinatal outcome.Methods The delivery 24-28 weeks pregnant or first diagnosed more than 28 weeks after the gynecology clinic diagnosis with diabetes in 125 singleton pregnant women and newborns were selected as the research object of study.Except giving birth to the same period 95 cases of normal of diabetes single fetus of pregnant women and their newborn for the control group.The complications of pregnancy and gestational age,birth and neonatal intrauterine nutrition status,mode of delivery,neonatal asphyxia,hypoglycemia and jaundice,case analysis,comparison.Results The two groups in the average age,average number of pregnancy pregnancy and intrauterine nutrition(group GDM,PI =2.717,control group 2.469) and the rate of neonatal asphyxia were not statistically significant(P ＞ 0.05).GDM group of 71 cases of cesarean section,natural childbirth in 54 cases,31 cases of control group difference and 64 cases,very significant differences between the two groups (x2 =12.678,P ＜ 0.01),group GDM,the incidence of neonatal jaundice neonatal hypoglycemia respectively 18.4%,24%,and 7.4% in the control group,there was significant difference compared with 12.6% (x2 =4.500,5.577,all P ＜0.05).Conclusion Gestational diabetes is the important reason which caused by adverse perinatal outcome.

Taking Children's Hospital of Fudan University as an example, the paper establishes a patient identity matching model based on the historical treatment data according to features of pediatric patients.It also sets up a uniform indexing mechanism of the his-torical treatment and hospitalization records of the patients by improving the existing business system, providing support patient identity recognition and laying a foundation for establishment of the clinical data center in future.

Objective:To evaluate the effects of early administration of dexmedetomidine on benzodiazepine ( BZD) requirements of intensive care unit ( ICU) patients with alcohol withdrawal syndrome ( AWS) .Methods:Totally 60 adult patients with severe AWS were chosen and randomly divided into groups A and group B with 30 patients in each .The patients in group A received benzodiazepine simultaneously with early administration of dexmedetomidine , and those in group B received only benzodiazepine .After the first admin-istration of dexmedetomidine , the 24-h cumulative BZD requirement , stay length in ICU and hospital , condition of mechanical ventila-tion and incidence of hypotension and bradycardia were recorded .Results:The 24-h cumulative BZD requirement in group A was obvi-ously lower than that in group B [(8.6 ±1.2) mg vs (25.6 ±4.9) mg, P<0.05].The number of patients with mechanical ventila-tion in the two groups was similar, while the duration of intubation in group A was less than that in group B [(24.9 3.1) h vs (48.8 6.9) h, P<0.05].Additionally, group A had higher incidence of bradycardia when compared with group B (57% vs 13%, P<0.05).Conclusion:As the adjuvant treatment for alcohol withdrawal syndrome , early administration of dexmedetomidine can notably decrease the benzodiazepine requirement of ICU patients .

Glaucoma ; diagnosis ; therapy ; Humans ; Research

Replacement therapy of stem cells transplantation represents a potential treatment for neural retinal diseases.Despite the encouraging results in laboratory,the clinical application of cells replacement therapy is still difficult because the limitation of seed cells,immunologic rejection,oncogenicity and ethical problems,etc.Recent breakthrough in somatic reprogramming provides a promising solution overcoming these obstacles.Further researches on virus-free reprogramming will make the clinical application of stem cell replacement therapy possible.

Objective To investigate the application value of cataract extraction surgery in the treatment of primary angle-closure glaucoma and cataract.Methods 132 patients of primary angle-closure glaucoma and cata-ract were randomly selected,these patients were divided into lensectomy treatment group(A group,n=66) and laser peripheral iridotomy treatment group(B group,n=66) according to the treatment method.The visual acuity,intraocu-lar pressure,anterior chamber depth,and complications of the two groups were analyzed statistically.Results In A group,the visual acuity <0.1 was in 0 case,0.1-0.3 in 12 cases,>0.3-0.4 in 20 cases,>0.4 in 34 cases, accounting for 0.00%,18.18%,30.30%,51.52%.In B group,the visual acuity <0.1 was in 5 cases,0.1-0.3 in 14 cases,>0.3-0.4 in 19 cases,>0.4 in 28 cases,accounting for 7.58%,21.21%,28.79%,42.42%.A group of visual acuity <0.1 proportion of patients was significantly lower than B group(χ2 =5.02,P<0.05) ,the propor-tion of patients >0.4 was significantly higher than B group(χ2 =7.38,P<0.05),but the differences of the propor-tion for 0.1-0.3,>0.3-0.4 vision between the two groups were not significant(χ2 =2.71,4.61,all P>0.05). The differences of the intraocular pressure and anterior chamber depth before surgery between the two groups were not significant(t=1.532,1.447,all P>0.05),the anterior chamber depth after surgery in group A was significantly lon-ger than B group(t=2.571,P<0.05),but the difference of IOP between the two groups was not significant(t=1.032,P>0.05).A group had corneal edema in 1 case,a transient high IOP in 4 cases,2 cases in hyphema,the postoperative complication rate was 10.61%.B group had corneal edema in 1 case,a transient high IOP in 4 cases, 2 cases in hyphema,the postoperative complication rate was 10.61%,the incidence rate of postoperative complica-tions in A group was significantly lower than B group(χ2 =9.35,P<0.05).Conclusion The application value of cataract extraction surgery in the treatment of primary angle -closure glaucoma and cataract is higher than laser peripheral iridotomy,which can more effectively improve visual acuity, prolong anterior chamber depth, reduce inci-dence of complications of patients,so it is more safe and effective,and worthy of promotion.

Objective To observe the clinical efficacy of percutaneous minimally invasive plate osteosynthesis(MIPPO) in treatment of senile proximal humeral fractures(SPHF).Methods The clinical data of 41 SPHF patients treated by MIPPO were analyzed retrospectively.The effect of surgery was evaluated by Neer scoring system.Results 41 patients were follow-up for 5 to 19 months (mean 11.6 months).Based on the Neer scoring criteria:the turn of excellent,good,fair or poor were 25 cases,12 cases,3 cases,1 case,the excellent rate was 90.2％.Never happened avascular necrosis of the humeral head,plate and screw fracture,nerve injury,fractures unhealed or delay healing and other negative phenomena.Conclusion The application of MIPPO in treatment of SPHF is easy to operate,little nerve damage,good fixed performance,high reliability,which is worthy of clinical application.

The feasibility and safety of non - operative treatment of splenic rupture were assessed experimentally in rats.All the experimental animals survived except that there was one death in the group with complete laceration of all the layers of the spleen and in the group with comminuted rupture of the spleen respectively.Non-operative treatment was used to treat 7 cases of single rupture of the spleen with satisfactory results.These findings suggest that non -operative treatment is an effective and safe procedure for the management of blunt injury of the spleen when hemodynamics of the patient is stable.

OBJECTIVE: To explore the materials and selection of esophageal stents, and to discuss the application of covered stants in treating esophageal malignant stenosis.METHODS: CNKI and Medline databases were retrieved by computer for papers published from 1980 to 2009 with search terms of "esophageal carcinoma, esophageal stenosis, esophageal stent, and fabric-covered metallic stent". The language was limited for Chinese and English. A total of 61 iteratures were initial searched by computer, according to inclusive and exclusive criteria, 29 literatures were selected by the first author. Problems including esophageal stent category, material selection, as well as application of covered stents in treating esophageal malignant stenosis were reviewed and summarized.RESULTS: Totally 29 literatures were included in this paper. No concealed allocation or blinding method was described in the literatures. According to preparing materials, the stents could be divided into stainless metal stent, memory metallic stent and polyester plastic stent. As tissue-engineered materials, stents could be assigned into biodegradable polymer matrix stent and non-degradable biodegradable polymers stent. Each material stent possesses distinct advantage and disadvantage. The covered stents could relief esophageal stenosis effectively, interrupt tumor growth, and prevent restenosis. CONCLUSION: As a palliative therapy for treating esophageal malignant stenosis, covered stents can elevate patients' life quality and prolong survival times.