OBJECTIVE: To summarize the occurrences of adverse drug reactions (ADR) of gatifloxacin, and to guide the rational usage of antibacterial agents in clinical practice in the future. METHODS: A total of 1 077 ADR patient who received gatifloxacin were retrospectively studied in Hunan province from August 2003 to July 2007. RESULTS: Gatifloxacin could cause multi-system and multi-organ ADRs with wide variety of clinical manifestations. Of the 1 077 ADR patients, ADR incidence rate was slightly lower in males than that in females, the age of 821 (76.23%) ADR patients were 20 approximately 59 years; 905 (84.03%) were administered intravenously; and 682 (33.07%) had severe lesions of the digestive system, followed by lesions of the skin and the appendants (490 cases, 23.76%) and the nervous system (298 cases, 14.45%). CONCLUSION ADR caused by gatifloxacin should be monitored and reported so as to reduce or avoid ADR.
Adolescent ; Adult ; Adverse Drug Reaction Reporting Systems ; Aged ; Aged, 80 and over ; Anti-Infective Agents ; adverse effects ; Child ; Child, Preschool ; China ; Drug-Related Side Effects and Adverse Reactions ; Female ; Fluoroquinolones ; adverse effects ; Gatifloxacin ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Young Adult