OBJECTIVETo investigate the effect of metoclopramide on capsule endoscopy (CE) examination.

METHODSTotal 116 patients referred for CE were randomized into two groups with 58 patients in each group. In treatment group patients received 10 mg metoclopramide intramuscular injection after swallowing the capsule and in control group no metoclopramide was administered. The gastric transit time, small bowel transit time, complete endoscopy rate were observed in both groups.

RESULTSThe CE examination was completed in 51 patients of treatment group (87.9%) and 48 of control group (84.2%). Mean gastric transit time was (32.45 ± 29.63) min in treatment group and (45.81 ± 40.01)min in control group, there was significant difference between two groups (P<0.05). Mean small bowel transit time was (252.69 ± 113.29) min in treatment group and (258.75 ± 83.83) min in control group, there was no significant difference between two groups (P>0.05).

CONCLUSIONMetoclopramide may reduces gastric transit time, but not effect small bowel transit time,which suggests that it might increase the likelihood of complete small-bowel examination in patients undergoing capsule endoscopy.

Adult ; Capsule Endoscopy ; Female ; Gastrointestinal Transit ; drug effects ; Humans ; Male ; Metoclopramide ; therapeutic use ; Middle Aged

OBJECTIVETo investigate the effect of morphine chloride on small intestinal muscle in vitro or in vivo and its mechanisms.

METHODSContractile amplitude, tension and frequency of the isolated small intestine of rabbits were measured before and after treatment of morphine chloride. The propulsive distance of magenta in intestinal tract was measured when different concentration of morphine chloride was given orally in mice.

RESULTAfter treatment of different concentration of morphine chloride (5 mg/L, 10 mg/L, 30 mg/L), the contractile activities of isolated small intestines of rabbits decreased significantly. The inhibitory effect of morphine chloride was blocked by naloxone, atropine, but potentiated by regitine. The propulsive distance of magenta in intestinal tract of intact mouse decreased after treatment with morphine chloride of various concentration (75, 150, 300 mg/L).

CONCLUSIONMorphine chloride has an inhibitory effect on the contractility of rabbit small intestine in vitro or in vivo. Opioid receptor, choline and adrenal receptor might be involved in this effect.

Animals ; Female ; Gastrointestinal Transit ; drug effects ; In Vitro Techniques ; Intestine, Small ; drug effects ; Male ; Mice ; Morphine ; pharmacology ; Muscle Contraction ; drug effects ; Muscle, Smooth ; drug effects ; Rabbits

Animals ; Body Weight ; Drugs, Chinese Herbal ; pharmacology ; Gastrointestinal Transit ; drug effects ; Male ; Mice ; Mice, Inbred Strains ; Rats ; Rats, Wistar ; Reishi

OBJECTIVETo observe the clinical efficacy of self-formulated Xingchang Decoction (XCD) in treating slow-transit constipation (STC) and the dynamical parameters of colonic motility during XCD treatment.

METHODSOne hundred and eighteen patients with STC were randomly assigned to the treatment group and the control group, 59 in each group. The treatment group was treated with XCD, and the control group was treated with mosapride, an intestinal energetic agent. The therapeutic course for both groups was 30 days. The 72-h colonic transition test was conducted and the symptom scores were observed before and after treatment; the adverse reaction rate and clinical efficacy were calculated after treatment; and the recurrence rate in one year was followed-up.

RESULTSSymptom scores were significantly improved in the treatment group after treatment, with the improvement significantly superior to that in the control group (P < 0.01). The cure rate and the total effective rate were 76.27% and 93.22% in the treatment group respectively, while they were 47.45% and 72.87% in the control group, showing significant difference between the two groups (P < 0.01). Besides, the 1-year recurrence rate was significantly lower (chi2 = 10.40, P = 0.001) and the improvement of colonic motor function was more in the treatment group than those in the control group (P < 0.01). Only low incidence (5.08% in the treatment group and 8.47% in the control group) of mild gastrointestinal reactions was shown, which caused no influence on the treatment.

CONCLUSIONXCD could effectively improve the motility of the digestive tract, and it is effective and safe for the treatment of STC.

Benzamides ; therapeutic use ; Constipation ; drug therapy ; Drugs, Chinese Herbal ; therapeutic use ; Gastrointestinal Agents ; therapeutic use ; Gastrointestinal Transit ; drug effects ; Humans ; Morpholines ; therapeutic use

OBJECTIVETo investigate the effects of ghrelin on small intestinal transit and intergigestive gastrointestinal migrating myoelectric complex (MMC) in rats.

METHODSAfter a 24-hour fasting, the rats with or without pretreatment with receptor antagonist (D-Lys3)GHRP-6 were given intravenous injections of ghrelin at different doses to observe the changes in small intestinal transit. The MMCs of the fasting rats were recorded using a multilead physiological recording system, and their changes observed in response to intravenous ghrelin injections, or to ghrelin injection following pretreatment with atropine, phentolamine, propranolol, L-arginine or (D-Lys3)GHRP-6, respectively.

RESULTSGhrelin enhanced the small intestinal transit dose-dependently, and this effect was inhibited by application of ghrelin receptor antagonist. Ghrelin also showed excitatory effect on the MMCs, which was inhibited by atropine, L-arginine or (D-Lys3)GHRP-6, but not by propranolol and phentolamine.

CONCLUSIONGhrelin can promote gastrointestinal motilities, and its excitatory effects rely on the cholinergic pathway in close relation to nitric oxide pathway. Ghrelin receptor is involved in its action in promoting the gastrointestinal motilities.

Animals ; Dose-Response Relationship, Drug ; Female ; Gastrointestinal Motility ; drug effects ; physiology ; Gastrointestinal Transit ; drug effects ; physiology ; Ghrelin ; administration & dosage ; pharmacology ; Injections, Intravenous ; Intestine, Small ; drug effects ; physiology ; Male ; Myoelectric Complex, Migrating ; drug effects ; physiology ; Random Allocation ; Rats ; Rats, Sprague-Dawley

Adult ; Aged ; Colon ; physiopathology ; Constipation ; drug therapy ; physiopathology ; Drug Combinations ; Drugs, Chinese Herbal ; therapeutic use ; Female ; Gastrointestinal Transit ; drug effects ; Humans ; Male ; Middle Aged ; Phytotherapy

OBJECTIVETo investigate the characteristic of colonic transmission in functional constipation (FC) and the effect of traditional Chinese medicine (TCM) Sini Powder (SP) on it.

METHODSThe colonic transmission time (CTT) of 36 patients with FC (the FC group) and 22 healthy subjects (control group) was measured through colonic transmission test, and CTT of entire colon and that of various subsections was calculated with Hinton method and Arhan method respectively. After then, the FC group was treated with SP for 7 days, and CTT was detected again after treatment.

RESULTSBefore treatment, body mass index (BMI) was higher, CTT of entire colon, left half colonic section, and sigmoid-rectal section were longer in the FC group than those in the control group (P < 0.05), no statistical difference in CTT of right half colon was found between the two groups (P > 0.05). After FC patients being treated with SP, their CTT of whole colon, left half colonic section and sigmoid-rectal section were significantly shortened (P < 0.05).

CONCLUSIONFC patients were characterized by increased BMI and CTT prolonged and unevenly distributed in subsections, especially in the left half colon, sigmoid and rectum; SP could shorten the CTT in FC patients.

Adult ; Body Mass Index ; Colon ; drug effects ; physiopathology ; Colon, Sigmoid ; drug effects ; physiopathology ; Constipation ; drug therapy ; physiopathology ; Drugs, Chinese Herbal ; therapeutic use ; Female ; Gastrointestinal Transit ; drug effects ; Humans ; Male ; Middle Aged ; Phytotherapy ; Time Factors ; Treatment Outcome

No abstract available.
Antidiarrheals/*therapeutic use ; Benzimidazoles/*therapeutic use ; Diabetes Mellitus, Type 2/*complications ; Diarrhea/diagnosis/*drug therapy/etiology/physiopathology ; Endoscopy, Gastrointestinal ; Gastrointestinal Transit/*drug effects ; Humans ; Male ; Middle Aged ; Serotonin 5-HT3 Receptor Antagonists/*therapeutic use ; Treatment Outcome

OBJECTIVETo observe the effects of Zhizhu Tongbian Decoction (ZTD) on the enteric nervous system, mRNA expressions of glial cell line derived neurotrophic factor (GDNF) and nitric oxide synthase (NOS) in the slow transit constipation (STC) rats.

METHODSThirty STC rat model was established by gastric irrigation of rhubarb. After the model building, they were randomly divided into three groups, i. e., the model group, the high dose ZTD group, and the low dose ZTD group, 10 in each. Another 10 rats were selected as the blank control group. Rats in the high dose ZTD group and the low dose ZTD group were administered with ZTD (at the daily dose of crude drug 4.8 g/kg and 2.4 g/kg respectively) by gastrogavage. Normal saline was given to rats in the blank control group and the model group. The ink propelling rate was determined using ink propelling test. Meantime, mRNA expressions of GDNF and NOS in the rat colon were measured using reverse transcriptional polymerase chain reaction (RT-PCR).

RESULTSCompared with the blank control group, the ink propelling rate and GDNF mRNA expression decreased, and NOS mRNA increased in the model group, showing statistical difference (P<0.01, P<0.05). Compared with the model group, the ink propelling rate increased in the high and low dose ZTD groups (P<0.01, P<0.05). The mRNA expressions of GDNF increased and the mRNA expressions of NOS decreased in the high dose ZTD group with statistical difference (P<0.01, P<0.05). But there was no difference in any index between the high and low dose ZTD groups.

CONCLUSIONHigh dose ZTD could obviously improve the intestinal transmission function possibly through up-regulating the mRNA expressions of GDNF and down-regulating the mRNA expressions of NOS in STC rats.

Animals ; Constipation ; drug therapy ; metabolism ; Drugs, Chinese Herbal ; therapeutic use ; Female ; Gastrointestinal Transit ; drug effects ; Glial Cell Line-Derived Neurotrophic Factor ; metabolism ; Male ; Nitric Oxide Synthase ; metabolism ; Phytotherapy ; RNA, Messenger ; genetics ; Rats ; Rats, Sprague-Dawley

OBJECTIVETo study the therapeutic effect and mechanism of Dachengqi granule (DCQG) on some digestive motility disturbed diseases.

METHODSGastroduodenojejunal manometry, electrogastrography (EGG), RIA of motilin and orocecal transit time test were applied to directly observe the effect of DCQG on human gastrointestinal motility.

RESULTSDCQG could significantly improve the postoperational EGG disorder, elevate the amplitude and time of migrating motor complex (MMC) phase III, prevent gastrointestinal reversed peristalsis, increase the blood level of motilin, decrease the orocecal transit time, and promote the recovery of gastrointestinal motility.

CONCLUSIONDCQG is an effective digestive kinetic agent, which could be medicated conveniently in treating digestive motility disturbed diseases.

Adult ; Cholecystectomy ; Colonic Neoplasms ; surgery ; Drugs, Chinese Herbal ; therapeutic use ; Female ; Gastrointestinal Motility ; drug effects ; Gastrointestinal Transit ; drug effects ; Humans ; Male ; Manometry ; Middle Aged ; Motilin ; blood ; Myoelectric Complex, Migrating ; drug effects ; Plant Extracts ; therapeutic use ; Postoperative Complications ; prevention & control ; Postoperative Period