1.Strategies in diagnosis and management for advanced or metastatic gastrointestinal stromal tumor.
Ying-jiang YE ; Zhi-dong GAO ; Shan WANG
Chinese Journal of Gastrointestinal Surgery 2012;15(3):213-216
With deeper understanding of gastrointestinal stromal tumor(GIST), more and more patients are diagnosed as GIST. Although the prognosis of early GIST is satisfactory after complete surgical resection, there are still many problems in the treatment of advanced GIST. Variety of treatment options has been used in the treatment of GIST, such as surgery, targeted drug therapy, and surgery plus imatinib therapy. However, post-operative recurrence, imatinib-resistance, multi-targeted drug resistance are still challenges. Many clinical evidences show that a reasonable management strategy can improve the prognosis of patients with advanced GIST. All the doctors should have a clear mind to carry out appropriate interventions. Advanced GIST should not be simply considered to be either medical or surgical disease, but rather must be systematically managed by multidisciplinary team approach combining surgical oncology, medical oncology, pathology, and interventional medicine. This review will advocate suitable treatment strategies based on the most recent progresses in systemic treatment for advanced GIST and our clinical experience to achieve early detection, early prevention, proper management, and therefore improve the survival of these patients.
Gastrointestinal Stromal Tumors
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diagnosis
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drug therapy
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pathology
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surgery
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Humans
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Neoplasm Metastasis
2.Successful Resection of Locally Advanced Gastrointestinal Stromal Tumor of the Ampulla of Vater after Treatment with Imatinib.
Jeung Eun PARK ; Seok Ho DONG ; Kun Hyung CHO ; Jae Young JANG ; Hyo Jong KIM ; Byung Ho KIM ; Young Woon CHANG ; Rin CHANG
The Korean Journal of Gastroenterology 2010;56(1):39-44
Gastrointestinal stromal tumor (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract arising from Cajal's cells, expressing CD 117. The standard treatment for primary GIST is complete surgical resection. Imatinib mesylate, a specific tyrosine kinase inhibitor, is effective against locally advanced and metastatic GIST. There are several reports of the effect of preoperative imatinib in patients with unresectable and locally advanced primary GIST. We report a case of unresectable primary GIST of the ampulla of Vater, which we were able to completely resect after treatment with a dosage of imatinib 400 mg daily for 5 months. Twelve months later, the patient was treated with imatinib and doing well with no evidence of recurrence.
Ampulla of Vater/*pathology
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Antineoplastic Agents/*therapeutic use
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Duodenoscopy
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Gastrointestinal Stromal Tumors/diagnosis/drug therapy/*surgery
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Humans
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Male
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Middle Aged
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Piperazines/*therapeutic use
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Pyrimidines/*therapeutic use
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Tomography, X-Ray Computed
3.Imatinib mesylate-induced interstitial lung disease in a patient with prior history of Mycobacterium tuberculosis infection.
Na Ri LEE ; Ji Won JANG ; Hee Sun KIM ; Ho Young YHIM
The Korean Journal of Internal Medicine 2015;30(4):550-553
No abstract available.
Adult
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Antineoplastic Agents/*adverse effects
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Antitubercular Agents/therapeutic use
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Biopsy
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Female
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Gastrointestinal Stromal Tumors/*drug therapy/pathology/surgery
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Humans
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Imatinib Mesylate/*adverse effects
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Lung Diseases, Interstitial/*chemically induced/diagnosis
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Mycobacterium tuberculosis/*isolation & purification
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Protein Kinase Inhibitors/*adverse effects
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Rectal Neoplasms/*drug therapy/pathology/surgery
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Tomography, X-Ray Computed
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Tuberculosis, Pulmonary/diagnosis/drug therapy/*microbiology
4.Recurrent follicular dendritic cell sarcoma in abdomen: report of a case.
Jing LIU ; Rui ZHANG ; Zheng-long ZHU ; Peng CAO ; Xia LI ; Ping ZHOU ; Wei ZHANG
Chinese Journal of Pathology 2010;39(10):709-710
Abdominal Neoplasms
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drug therapy
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metabolism
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pathology
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secondary
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surgery
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Dendritic Cell Sarcoma, Follicular
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drug therapy
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metabolism
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pathology
;
surgery
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Dendritic Cell Sarcoma, Interdigitating
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metabolism
;
pathology
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Diagnosis, Differential
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Female
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Gastrointestinal Stromal Tumors
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metabolism
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pathology
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Histiocytoma, Malignant Fibrous
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metabolism
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pathology
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Humans
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Middle Aged
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Neoplasm Recurrence, Local
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Omentum
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Peritoneal Neoplasms
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secondary
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Receptor, Epidermal Growth Factor
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metabolism
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Receptors, Complement 3b
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metabolism
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Receptors, Complement 3d
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metabolism