1.Choice of nutritional plans for patients with gastrointestinal neoplasms.
Chinese Journal of Gastrointestinal Surgery 2012;15(5):437-439
Malnutrition is the common complication for patients with gastrointestinal neoplasms. Nutrition therapy is the key and first step, but there are some uncertain questions in the clinical practices. We will discuss some experiences on selecting nutrition plans for patients with gastrointestinal neoplasms.
Gastrointestinal Neoplasms
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therapy
;
Humans
;
Nutritional Support
;
methods
2.Research Advances in the Role of Keratins in Gastrointestinal Cancer.
Chinese Medical Sciences Journal 2022;37(1):73-78
The incidence and mortality rates of gastrointestinal (GI) cancer remain high. Despite constant improvements in diagnostic and therapeutic techniques, the early diagnosis, mid- and late-stage treatment, drug tolerance, and cancer recurrence and metastasis in GI cancer remain challenging. In this review article we summarize the recent research advance in the roles of keratins in GI cancer, with the hope that they will become efficient biomarkers for the prediction, diagnosis, or treatment of these malignancies.
Biomarkers, Tumor
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Gastrointestinal Neoplasms/therapy*
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Humans
;
Keratins
3.Progress of biotherapy in gastrointestinal carcinomas.
Jian-chuan XIA ; De-sheng WENG
Chinese Journal of Gastrointestinal Surgery 2013;16(1):22-27
Gastrointestinal carcinomas are among the malignancies with highest morbidity and mortality. The survival rates of these tumors remain pretty low in spite of advancements of traditional treatments. As the fourth treatment method besides surgery, radiotherapy and chemotherapy, biotherapy has shown promising prospect in improving the prognosis of gastrointestinal carcinomas. In this manuscript, we summarized the current progress of biotherapy in gastrointestinal tumors including gene therapy, immune therapy and molecular targeted therapy.
Biological Therapy
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Gastrointestinal Neoplasms
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therapy
;
Genetic Therapy
;
Humans
;
Immunotherapy
4.Management of liver metastases of gastrointestinal stromal tumor.
Chinese Journal of Gastrointestinal Surgery 2012;15(3):221-224
Liver is the most common metastatic site of gastrointestinal stromal tumor(GIST). The recurrence rate is high even after hepatectomy. Although tyrosine kinase inhibitors (TKI) makes the resection feasible for some of the liver metastasis of GIST and significantly increase the overall survival, surgery still can not be substituted. Therefore, it is worth investigating and exploring the most appropriate treatment for the GIST with liver metastasis.
Gastrointestinal Stromal Tumors
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pathology
;
therapy
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Humans
;
Liver Neoplasms
;
secondary
;
therapy
5.Interpretation of updated international guidelines for diagnosis and treatment of gastroenter-opancreatic neuroendocrine neoplasms.
Chinese Journal of Gastrointestinal Surgery 2021;24(10):843-848
The incidence of neuroendocrine neoplasms (NEN) is continuously increasing with gastrointestinal tract and pancreas being the most common primary sites. Currently, the guidelines proposed by European Neuroendocrine Tumor Society (ENETS), National Comprehensive Cancer Network (NCCN), European Society for Medical Oncology (ESMO) and North American Neuroendocrine Tumor Society (NANETS) are being widely applied. Among these, ENETS and NANETS guidelines were proposed in 2017 while ESMO and NCCN recently updated their guidelines for gastroenteropancreatic NEN in 2020 and 2021, respectively. This article interprets the diagnosis and treatment of gastroenteropancreatic NEN based on the newly updated ESMO and NCCN guidelines. The diagnosis of gastroenteropancreatic NEN depends on histological assessment including morphological evaluation, grading and immunohistochemistry results. Combination of different imaging methods can help determine tumor staging and risk assessment. Decision-making of treatment and follow-up strategies is based on primary tumor site, tumor classification, tumor grade, tumor type, functional status etc.
Gastrointestinal Neoplasms/therapy*
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Humans
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Incidence
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Neoplasm Staging
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Neuroendocrine Tumors/therapy*
6.Surgical principles of gastrointestinal stromal tumors at different locations.
Yingjiang YE ; Zhidong GAO ; Shan WANG
Chinese Journal of Gastrointestinal Surgery 2015;18(4):301-304
Gastrointestinal stromal tumors(GIST) are the most common mesenchymal tumors in gastrointestinal tract. At present, surgical and molecular targeted therapies are the main treatments. Operation is properly the only way of radical resection. The general principles of surgery are complete resection of the tumor, negative margins, as well as no intraoperative tumor rupture. The choice of surgical skills for GIST is obviously affected by different locations. This paper reviews current literatures combined with our experiences, and elaborates relevant contents in detail.
Gastrointestinal Neoplasms
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Gastrointestinal Stromal Tumors
;
Humans
;
Molecular Targeted Therapy
;
Neoplasms, Connective and Soft Tissue
7.Diagnosis and treatment of duodenal gastrointestinal stromal tumors.
Tong LIU ; Weidong LI ; Weijun TIAN
Chinese Journal of Gastrointestinal Surgery 2015;18(4):316-320
In order to promote clinical capability on duodenal gastrointestinal stromal tumor(GIST), literature review and experience summary were documented in this paper. Duodenal GIST is not rare in clinical practice. With the similar pathologic conditions, GIST in duodenum present a higher malignant risk than that in stomach. The cases who would receive imatinib mesylate as preoperative therapy require a precise preoperative diagnosis obtained by endoscopic ultrasound and fine needle aspiration cytology. Therapeutic strategy should be based on surgical R0 resection with clear margins, preserving pancreatic function and avoiding adjacent organs resection when possible. Limited resection is appropriate and results in similar oncological outcome compared with extensive procedure in suitable cases.
Duodenal Neoplasms
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Endosonography
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Gastrointestinal Stromal Tumors
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Humans
;
Neoadjuvant Therapy
;
Stomach
8.Molecular markers of gastrointestinal tumors and individualized treatment.
Chinese Journal of Gastrointestinal Surgery 2014;17(1):6-9
Gastrointestinal cancer is one of the most common malignant tumors in China which affects people health seriously. Along with the investigation of the cancer molecular markers and the application of novel target agents, the therapeutic modalities for gastrointestinal cancers have been changing gradually. More and more target drugs, such as trastuzumab, cetuximab, bevacizumab,have been used in clinical practice. The individualized therapy based on the molecular classification will benefit more patients and is the inevitable trend of gastrointestinal cancer treatments in the future.
Biomarkers, Tumor
;
Gastrointestinal Neoplasms
;
metabolism
;
therapy
;
Humans
;
Precision Medicine
9.Nutritional support in the treatment of patients with gastrointestinal cancer.
Chinese Journal of Gastrointestinal Surgery 2014;17(10):955-959
Patients with gastrointestinal(GI) tract neoplasms usually suffer from malnutrition, which is associated with increased morbidity and mortality, reduction of treatment efficacy, increased risk of therapy-associated side-effects, increased length of hospital stay, and reduced quality of life. Proposing an adaptive nutritional support at each step of a multidisciplinary treatment approach for GI cancer is essential.
Gastrointestinal Neoplasms
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therapy
;
Humans
;
Nutritional Support
;
Quality of Life
10.Application of precise radiotherapy in the combined modality therapy of gastrointestinal tract tumors.
Chinese Journal of Gastrointestinal Surgery 2013;16(6):501-504
Single modality treatment of advanced gastrointestinal cancer has been associated with unfavorable outcomes. Radiotherapy as an important component of the combined modality therapy of gastrointestinal tract tumors may achieve down-staging, increase resection rate while preserving sphincter function, decrease local recurrence rate, and improve survival rate. Precision radiotherapy has better conformity, accuracy, and lower toxicity. Precision radiotherapy will become more and more important in the combined modality therapy of gastrointestinal tract cancer.
Combined Modality Therapy
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Gastrointestinal Neoplasms
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radiotherapy
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Humans
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Radiotherapy, Adjuvant
;
methods