1.A Clinical and Immunohistochemical Study on Gastrointestinal Stromal Tumor.
Eun Jung LEE ; Ok Jae LEE ; Tae Hyo KIM ; Woon Tae JUNG
The Korean Journal of Gastroenterology 2003;42(3):204-211
BACKGROUND/AIMS: As the relationship between gastrointestinal stromal tumors (GIST) and interstitial cells of Cajal had become clear, GIST is defined as CD117 positive mesenchymal tumors, and recognized as a new distinct entity among mesenchymal tumors presenting as gastrointestinal submucosal tumors (SMT). To evaluate GISTs in the category of SMTs, we analyzed mesenchymal SMTs immunohistochemically and clinicopathologically. METHODS: Forty-five patients with mesenchymal SMTs, who received surgical or endoscopic resection were retrospectively analyzed for clinical parameters. Immunohistochemical staining for CD117, CD34, NSE, SMA, and S-100 was also performed. RESULTS: Among 45 tumors, 41 (91.1%) expressed CD117 and were diagnosed as GIST. The most frequent location was the gastric body. Except esophageal location (73.3%), GISTs accounted for 100% of SMTs in the gastrointestinal tract. The mixed myoid-neural differentiated type and the spindle cell shape were most common. Metastasis was observed in 5 patients (11%). All of them had tumors larger than 5 cm and died. Their mean survival was 4.6 months. CONCLUSIONS: GIST accounted for majority (91.1%) of SMTs. The presence of metastasis and tumor size at the time of diagnosis indicate poor prognostic factors. Immunohistochemical study is necessary for exact diagnosis of GIST.
Adult
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Aged
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Female
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Gastrointestinal Neoplasms/*chemistry/diagnosis/pathology
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Humans
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Immunohistochemistry
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Male
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Middle Aged
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Prognosis
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Proto-Oncogene Proteins c-kit/analysis
2.Role of CDX2 immunostaining in diagnosis of gastrointestinal adenocarcinoma.
Chinese Journal of Pathology 2006;35(4):228-231
OBJECTIVETo study the expression of CDX2 in normal and tumor tissues, and to evaluate the value of CDX2 immunostaining in the diagnosis of gastrointestinal adenocarcinoma.
METHODSeventy-six samples of normal tissue and 612 samples of tumor tissue were studied by tissue microarray technology and immunohistochemistry for CDX2.
RESULTSCDX2 was strongly expressed in surface epithelium of 13 samples of normal intestine and in ductal epithelium of 8 samples of normal pancreas, as well as in 47 samples (92.2%) of colonic adenocarcinoma and 58 samples (66.9%) of gastric adenocarcinoma. As for other tumor types, there was only weak or patchy CDX2 positivity. The positivity rates were as follows: ovarian mucinous adenocarcinoma 15.6% (10/64), pancreatic cancer 33.3% (3/9), thyroid cancer 27.3% (3/11) and extrahepatic biliary cancer 25% (4/16). On the other hand, primary tumors of breast, prostate, kidney, adrenal and liver were negative for CDX2.
CONCLUSIONSCDX2 is expressed mainly in normal epithelium of intestinal tract and small pancreatic ducts, as well as in primary adenocarcinoma of gastrointestinal tract. CDX2 may thus play an important role in distinguishing primary non-intestinal adenocarcinoma from metastatic adenocarcinoma of gastric or colorectal primary.
Adenocarcinoma ; diagnosis ; metabolism ; CDX2 Transcription Factor ; Colonic Neoplasms ; diagnosis ; metabolism ; Female ; Gastrointestinal Neoplasms ; diagnosis ; metabolism ; Gastrointestinal Tract ; chemistry ; pathology ; Homeodomain Proteins ; metabolism ; Humans ; Immunohistochemistry ; Male ; Stomach Neoplasms ; diagnosis ; metabolism ; Tissue Array Analysis
3.Utility of Thyroid Transcription Factor-1 and Cytokeratin 20 in Identifying the Origin of Metastatic Carcinomas of Cervical Lymph Nodes.
Journal of Korean Medical Science 2002;17(4):512-517
The identification of primary location of a metastatic tumor is a difficult diagnostic problem and sometimes can be facilitated by the use of immunohistochemical markers. Thyroid transcription factor-1 (TTF-1) is a 38-kDa nuclear homeodomain transcription factor that is expressed specifically in lung or thyroid neoplasms. Cytokeratin 20 (CK20) is a 46-kDa low-molecular-weight cytokeratin that shows restricted expression in adenocarcinomas of the gastrointestinal tract (GIT) and transitional cell carcinomas of the urinary tract. We studied the immunohistochemical expression of TTF-1 and CK20 in 68 metastatic carcinomas in cervical lymph nodes. The primary sites were the lung in 29 cases, stomach in 13, colorectum in 3, and other sites in 23. TTF-1 expression was detected in 69.0% of metastatic lung carcinomas and none in metastatic GIT carcinomas, whereas CK20 expression was detected in 68.8% of metastatic GIT carcinomas and none of metastatic lung carcinomas. TTF-1 had a specificity of 0.95 and a sensitivity of 0.69 for metastatic lung carcinoma, whereas CK20 had a specificity of 1.00 and a sensitivity of 0.69 for metastatic GIT carcinoma. These results indicate that TTF-1 and CK20 should be the first choice as a component of antibody panel to prove or to exclude the lung and GIT origin, respectively, especially in patients presenting with metastatic carcinomas of unknown primary site.
Adenocarcinoma/chemistry/pathology/secondary
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Carcinoma/chemistry/pathology/*secondary
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Gastrointestinal Neoplasms/chemistry/pathology
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Homeodomain Proteins/analysis
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Humans
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Intermediate Filament Proteins/*analysis/immunology
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Keratin-20
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Lung Neoplasms/chemistry/pathology
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Lymph Nodes/chemistry/pathology
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Lymphatic Metastasis/*diagnosis/pathology
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Neck
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Neoplasms, Unknown Primary/chemistry/pathology
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Nuclear Proteins/*analysis/immunology
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Sensitivity and Specificity
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Transcription Factors/*analysis/immunology
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Tumor Markers, Biological/analysis
4.Malignant acanthosis nigricans in a patient with a gastrointestinal stromal tumor.
Keon Woo PARK ; Do Hyoung LIM ; Soon Il LEE
The Korean Journal of Internal Medicine 2013;28(5):632-633
No abstract available.
Acanthosis Nigricans/diagnosis/*etiology
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Biopsy
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Gastrointestinal Stromal Tumors/chemistry/*complications/pathology
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Humans
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Immunohistochemistry
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Laparoscopy
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Male
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Middle Aged
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Paraneoplastic Syndromes/diagnosis/*etiology
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Peritoneal Neoplasms/chemistry/*complications/pathology
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Proto-Oncogene Proteins c-kit/analysis
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Tomography, X-Ray Computed
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Tumor Markers, Biological/analysis
5.Mass of posterior gastric wall.
Ying-yong HOU ; Lian CHEN ; Li-ming XU ; Yan-nan ZHOU ; Sujie ARKSU ; Hai-ying ZENG ; Tao LIU
Chinese Journal of Pathology 2006;35(5):312-313
Actins
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metabolism
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Child, Preschool
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Diagnosis, Differential
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Female
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Follow-Up Studies
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Gastrectomy
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methods
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Gastrointestinal Stromal Tumors
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pathology
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Humans
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Immunohistochemistry
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Myofibroma
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metabolism
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pathology
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surgery
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Stomach
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chemistry
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pathology
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surgery
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Stomach Neoplasms
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metabolism
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pathology
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surgery
6.Gastrectomy for the treatment of refractory gastric ulceration after radioembolization with 90Y microspheres.
Sun Young YIM ; Jin Dong KIM ; Jin Yong JUNG ; Chang Ha KIM ; Yeon Seok SEO ; Hyung Joon YIM ; Soon Ho UM ; Ho Sang RYU ; Yun Hwan KIM ; Chong Suk KIM ; Eun SHIN
Clinical and Molecular Hepatology 2014;20(3):300-305
Transcatheter arterial radioembolization (TARE) with Yttrium-90 (90Y)-labeled microspheres has an emerging role in treatment of patients with unresectable hepatocellular carcinoma. Although complication of TARE can be minimized by aggressive pre-evaluation angiography and preventive coiling of aberrant vessels, radioembolization-induced gastroduodenal ulcer can be irreversible and can be life-threatening. Treatment of radioembolization-induced gastric ulcer is challenging because there is a few reported cases and no consensus for management. We report a case of severe gastric ulceration with bleeding that eventually required surgery due to aberrant deposition of microspheres after TARE.
Aged
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Carcinoma, Hepatocellular/*diagnosis/radiotherapy
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Embolization, Therapeutic/*adverse effects
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Gastrectomy
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Gastrointestinal Hemorrhage/etiology
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Gastroscopy
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Humans
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Liver Neoplasms/*diagnosis/radiotherapy
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Magnetic Resonance Imaging
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Male
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*Microspheres
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Radiopharmaceuticals/therapeutic use
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Stomach/pathology
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Stomach Ulcer/*etiology/surgery
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Yttrium Radioisotopes/chemistry