AIMIn order to decrease the destruction on the intestine wall, increase the same pace of the recording electric and mechanic activity and make the method simple during recording of intestine activity.

METHODSSilver ball electrode was held upon the strain gauge plate by silica gel which was a 2 mm 5 mm 9 mm recording device to be sewed only through the four corner point on to the intestine.

RESULTS AND CONCLUSIONIt had little destruction on the intestine and was more easy and the recording electric activity was in almost the same pace of the motion.

Animals ; Electrodes ; Electromyography ; methods ; Gastrointestinal Motility ; physiology ; Intestine, Small ; physiology

Many diseases of gastrointestinal tract have close relation to the changes in gastrointestinal (GI) motility. Making use of the technique of MEMS, we developed a micro-interposed system to monitor the motility and pH value of the whole GI tract under normal physical state. This paper focuses on an automatic analysis of the acquired signal to draw conclusions for aiding diagnosis of diseases. The techniques of smoothing signal, removing singular value, feature extraction and selection as well as classification of normal and abnormal samples are discussed in details. These techniques provide a comprehensive method for analyzing long-term motility recordings which will complete the function of the in vivo monitoring system and serve for medical applications.
Gastrointestinal Diseases ; physiopathology ; Gastrointestinal Motility ; physiology ; Humans ; Signal Processing, Computer-Assisted ; instrumentation

In recent years, colonic manometry has been gradually introduced into clinical practice. It helps clinicians to gain a better understanding of the physiology and pathophysiology of colonic contractile activity in healthy adults and patients with colonic dysfunction. More and more patterns of colonic motility are being discovered with the help of colonic manometry. However, the clinical significance of these findings still needs to be further investigated. This review enhances our understanding of colonic motility and the current state of development and application of colonic manometry, as well as the limitations, future directions and potential of the technique in assessing the impact of treatment on colonic motility patterns, by analyzing and summarizing the literature related to colonic manometry.
Humans ; Adult ; Gastrointestinal Motility/physiology* ; Colon/physiology* ; Colonic Diseases ; Manometry/methods* ; Clinical Relevance ; Constipation

AIMTo investigate the role of motilin in paraventricular nucleus (PVN) of hypothalamus on the regulation of gastric motility and the mechanism.

METHODSImmunohistochemistry and microinjection of motilin into PVN were used to observe motilin neural cells in PVN, the neural path between PVN and dorsal vagal complex (DVC) and the changes of gastric motility in conscious rats.

RESULTS(1) There were motilin immunoreactive-cells in PVN and a significant increase was found in groups of fasting and HCL-perfusion into duodenum. (2) HRP-positive cells were found in PVN after microinjection HRP into dorsal nucleus of vagal nerve. It proved that there was neural relationship between PVN and DVC. (3) The amplitude and frequency of gastric motility increased significantly by microinjection motilin into PVN in conscious rats. The effects produced by motilin could be abolished by vagotomy.

CONCLUSIONAll these results presented imply that motilin in PVN may increase gastric motility through PVN-DVC-Vagal nerve axis.

Animals ; Female ; Gastrointestinal Motility ; physiology ; Hypothalamus ; physiology ; Male ; Motilin ; physiology ; Paraventricular Hypothalamic Nucleus ; physiology ; Rats ; Rats, Wistar

Child ; Child, Preschool ; Constipation ; diagnosis ; physiopathology ; therapy ; Digestive System ; microbiology ; physiopathology ; Gastrointestinal Hormones ; physiology ; Gastrointestinal Motility ; physiology ; Humans

Adolescent ; Anal Canal ; physiopathology ; Child ; Constipation ; physiopathology ; Female ; Gastrointestinal Motility ; physiology ; Humans ; Male ; Rectum ; physiopathology

Diabetes patients tend to have the gastrointestinal motility disorder. Although the relationship between the motility disorder and both the neurons and Cajal cells in the enteric nervous system (ENS) is well established, little is known about the role of enteric glial cells (EGCs) in gastric motility in diabetes. This study aimed to examine the expression of the glial marker S100B and morphology of EGCs in gastric tissues and the relationship between activated EGCs and the damage of gastric emptying in diabetic models. The diabetic model of rat was induced with 1% streptozotocin (STZ). The model rats at 7-14 days and at 56-63 days were defined as early diabetic rats and advanced diabetic rats, respectively, and normal rats at the two time periods served as their corresponding controls. The gastric emptying rate of the rats was tested by using the phenol red solution. The ultrastructure of EGCs in the gastric antrum was observed by the transmission electron microscopy, and the expression of S100B in the myenteric plexus was immunohistochemically detected. The results showed that the gastric emptying rate was significantly increased in the early diabetic rats and decreased in the advanced diabetic rats when compared with their corresponding control rats (P<0.01 for both). The ultrastructure of EGCs was mostly normal in both the early diabetic and control groups. Vacuolization of mitochondria and expansion of endoplasmic reticulum occurred in both the advanced diabetic group and its control group, and even the structure of smooth muscle cells and intestinal neurons was destroyed in the advanced diabetic group. The expression level of S100B in the advanced diabetic group was significantly decreased compared with its control group (P<0.05). It was obviously increased in the early diabetic control group when compared with the advanced diabetic control group (P<0.05). However, there was no significant difference in the S100B expression between the early diabetic group and its control group (P>0.05). The findings suggested that the gastric motility dysfunction in diabetes may be associated with the changes of morphology and number of EGCs in the myenteric plexus.
Animals ; Diabetes Mellitus, Experimental ; pathology ; Gastrointestinal Motility ; physiology ; Male ; Neuroglia ; pathology ; Rats ; Rats, Sprague-Dawley

OBJECTIVETo investigate regulative effect of electroacupuncture (EA) of different frequencies on derangement of gastric electric rhythm in rabbits.

METHODSDerangement of gastric electric rhythm model was made with injection of erythromycin into ear vein in 40 rabbits, and randomly divided into a model group, a 3 Hz-EA group, a 20 Hz-EA group and a 100 Hz-EA group. They were treated with EA at Zusanli (ST 36) with 3 Hz, 20 Hz and 100 Hz, respectively. PDP and PTP at different periods were detected with IEGG spectrum analyzer.

RESULTSErythromycin could significantly enhance PDP and PTP values in the rabbit (P < 0.001). PDP and PTP values were reduced significantly after EA with 3 Hz, 20 Hz and 100 Hz (P < 0.05), with no significant differences in effect on PDP among them (P > 0.05); therapeutic effect of the EA of 20 Hz on PTP was better than that of 3 Hz (P < 0.05), with no significant difference as compared with the EA of 100 Hz.

CONCLUSIONEA of the 3 frequencies shows significantly different regulative effects on derangement of gastric electric rhythm in rabbits.

Animals ; Electroacupuncture ; Erythromycin ; pharmacology ; Female ; Gastrointestinal Motility ; drug effects ; Male ; Rabbits ; Stomach ; physiology

AIMTo explore the effect of central serotonin (5-hydroxytryptamine, 5-HT) on gastric motility in rabbit and to analysis its mechanism.

METHODSIntracerebroventricular (icv) microinjection of drugs were used. The frequency and the amplitude of contractions of gastric motility were recorded.

RESULTS(1) Injection (icv) of 25 microg 5-HT increased the amplitude of contractions and decreased the frequency of gastric motility. (2) The effects of 5-HT were inhibited by injection (icv) of atropine, but intravenous(iv) injection of atropine could only block the increase effect of 5-HT on intragastric pressure. After injection (icv or iv) of phentolamine or propranolol, the effects of 5-HT on gastric motility were not changed markedly. (3) Microinjection (icv) of naloxone or diphenhydramine inhibited the inhibitory effect of 5-HT on the frequency of gastric contractions, and the diphenhydramine reversed the increase effect of 5-HT on intragastric pressure. (4) Vagotomy abolished the effects of 5-HT completely.

CONCLUSIONThere may be different nerve mechanisms in regulation of central 5-HT on the frequency and amplitude of contractions of gastric motility. The increase effect of 5-HT on intragastric pressure is medicated by the cholinergic system in brain, and histamine may be one of the important element on the effect of 5-HT. The cholinergic fibers in vagus nerve transmit the effect. The inhibitory effect of 5-HT on the frequency of contractions is also medicated by activating the cholinergic system in brain, enkephalin and histamine are also involved, and it is transmitted via noncholinergic and nonadrenergic fibers in vagus nerve.

Animals ; Gastrointestinal Motility ; drug effects ; physiology ; Lateral Ventricles ; Rabbits ; Serotonin ; administration & dosage ; pharmacology

This paper introduces an eight channels dada acquisition system. A peripheral circuit based on C8051F340 MCU has been designed and its USB controller is used to transfer data, which realizes real-time detection, display and storage of bowel sounds. The system has many advantages such as high precision and stable performance, and thus provides a new means for the bowel sounds study.
Equipment Design ; Gastrointestinal Motility ; physiology ; Signal Processing, Computer-Assisted ; instrumentation ; Sound