Proton pump inhibitors (PPIs) are widely used in clinical practice from early 1990s for the treatment of acid- related diseases. PPIs are superior to histamine2-receptor antagonists or anticholinergic agents. These drugs have proven to be effective, safe and well-tolerated during the past two decades. This brief review presents the pharmacodynamics and pharmacokinetics of PPIs and presents clincal applications of the drugs in acid-related diseases.
Gastric Acid/*secretion ; Gastrointestinal Agents/pharmacokinetics/*pharmacology/therapeutic use ; Humans ; Proton Pumps/*antagonists & inhibitors