No abstract available.
Gastrins*

No abstract available.
Colostrum* ; Gastrins* ; Humans* ; Immunoglobulins* ; Milk*

No abstract available.
Gastrin-Secreting Cells* ; Gastrins* ; Gastrointestinal Tract*

Gastric neuroendocrine tumors are rarely seen in the gastric tumors, because there are few case reports and the clinical diagnosis rate is low. There is no consensus treatment method in the world. However, with the benefit of esophagogastrodenoscopy and widespread use of proton pump inhibitors, the diagnostic rate of gastric neuroendocrine tumors is on the increase, which gives us an updated understanding for the pathogenesis and pathophysiology of the disease. By studying its pathogenesis, scholars have found that hypergastrinemia caused by various causes is closely related to its occurrence. Gastric neuroendocrine tumors are classified into different types or pathological grades depending on the state of progression of the disease and the unique clinical manifestations. Clinically used diagnostic methods include gastroscopy, medical imageology, nuclear medicine, gastrin, CgA, etc. There are also differences in treatments depending on the clinical classification. If the disease progresses rapidly and the grade is high, surgical resection of the lesion plus postoperative adjuvant chemotherapy should be actively performed. Other better treatments are still being explored.
Gastrins ; Gastroscopy ; Humans ; Neuroendocrine Tumors ; Proton Pump Inhibitors ; Stomach Neoplasms

BACKGROUND/AIMS: It has recently been reported that non-amidated gastrin is associated with the development of colon cancer. However it is not known whether amidated gastrin, atrophic gastritis, and the status of Helicobacter pylori (H. pylori) infection are related to colon cancer. The aims of this study were to determine whether plasma level of amidated gastrin is elevated in patients with colon cancer compared with controls and to determine whether H. pylori infection and/or atrophic gastritis affect the relationship between amidated gastrin and colon cancer. METHODS: Twenty-two patients with colon cancer and twenty-two controls were enrolled in this study and their plasma amidated gastrin titers were measured by 125I radioimmunoassay. H. pylori infection was determined by histology. The degree of mucosal atrophy was determined by Sidney classification. RESULTS: Amidated gastrin levels were not different between the patients with colon cancer and controls. The status of H. pylori infection did correlate with amidated gastrin levels. Antral mucosal atrophy was not also correlated with amidated gastrin levels, but there was a tendency (p=0.074). CONCLUSIONS: Amidated gastrin is not related to the development of colon cancer.
Atrophy ; Classification ; Colon* ; Colonic Neoplasms* ; Gastrins* ; Gastritis, Atrophic* ; Helicobacter pylori* ; Helicobacter* ; Humans ; Plasma ; Radioimmunoassay

BACKGROUND/AIMS: Clinical isolates of Helicobacter pylori (H. pylori) can be divided into at least two major types. Type I bacteria express VacA (vacuolating cytotoxin) and CagA (cytotoxin-associated antigen), type II bacteria do not exp~ress VacA or CagA. The purpose of this study is to evaluate the changes of gastric histology and serum level of gastric peptides (gastrin and pepsinogen) according to the bacteriological types in H. pylori infection. METHODS: In patients with H. pylori-positive functional dyspepsia, we classified the type of infection serologically by detecting IgG antibodies to CagA and VacA. Each patient was also evaluated for the degree of gastric inflammation and serum concentrations of gastrin and pepsinogen (PG). IgG antibodies to these proteins and concentrations of gastrin and PG were detected by using a immuno-blot kit and a radioimmunoassay kit, respectively, from the sera of each patient. From endoscopically biopsied antral specimens, the degree of gastric inflammation was evaluated by scoring inflammatory changes.
Antibodies ; Bacteria ; Dyspepsia* ; Gastrins ; Helicobacter pylori* ; Helicobacter* ; Humans ; Immunoglobulin G ; Inflammation ; Pepsinogen A ; Peptides* ; Radioimmunoassay

PURPOSE: Gastrin is a candidate for the growth regulatory factors of the pancreas and may solve the problem of pancreatic atrophy after partial pancreatectomy. The purpose of this study was to evaluate the effect of endogenous gastrin on the normal growth and regeneration of the pancreas (after partial pancreatectomy) in rat. METHODS: Sixty Sprague-Dawley rats (200-230 g) were divided into 6 groups. Group (G)-I and II received sham operation (splenectomy only), and G-III, IV, V, VI received both 66% partial pancreatectomy (PPx) and splenectomy. Endogenous hypergastrinemia was induced in G-II, IV, VI by stomach gavage of 30 mg/kg.day of Lansoprozole (LSP) for 3 weeks. In G-V and VI, L365,260 (ML lab, UK) was given continuously in a dose of 50 microgram/kg/hour intraperitoneally using osmotic mini pump. The rats were sacrificed 3 weeks later, and serum gastrin, the weight and the amount of DNA, RNA, and protein in the remnant pancreas or corresponding part were checked. RESULTS: Serum gastrin concentration was 3-4 times higher in the groups received LSP. LSP stimulated growth of the pancreas (G-I: 11921 vs. G-II: 14220 mg/100 g body weight, p=0.047), and the effect was even greater in partial pancreatectomy groups (G-III: 14616 vs. G-IV: 17318 mg/100 g body weight, p=0.007). Total DNA, RNA, and protein amount in the remnant pancreas showed the same trends as the pancreas weight. The effect of LSP was totally abolished by L365,260 (G-V: 13517 vs. G-VI: 14313 mg/100 g body weight, p>0.047). CONCLUSION: Endogenous gastrin has a stimulatory effect on normal growth, and a much stronger effect on the regeneration of the rat pancreas after partial pancreatectomy. Further investigations including clinical trial should be needed.
Animals ; Atrophy ; Body Weight ; DNA ; Gastrins* ; Pancreas ; Pancreatectomy ; Rats* ; Rats, Sprague-Dawley ; Regeneration* ; RNA ; Splenectomy ; Stomach

OBJECTIVE: To explore the difference of some endocrine hormore of healthy pillots and the orthostatic intolerance pilots with coriolis acceleration Increased. METHODS: The coriolis acceleration of 3.75 pai 2cm/s2, 5.00 pai 2cm /s2, 6.25 pai 2cm/s2, was given with a Interval of 3-4 min In 12 flying syncope and 12 healthy pilots, AT-II, Isulin Cortisol, Aldosterone, Gastric were measured by radio immunossay. RESULT : All polits Showed that Aldosterone, AT-II, Gastrin were increased with coriolis acceleration Increased (p<005). Cortisol, Insulin of healthy pilots Increased (p<0,05). CONCLUSIONS : It was considered that endocrine hormone may be used In the autonomic nervous system evaluation Excitation of the autonomic nervous system ol healthy pilots were increased with coriolis acceleration acted, but the orthostatic intolerance pailots decrease.
Aldosterone ; Autonomic Nervous System ; Coriolis Force* ; Diptera ; Gastrins ; Hydrocortisone ; Insulin ; Orthostatic Intolerance ; Syncope

BACKGROUND/AIMS: Some studies showed the higher prevalence of H. pylori infection in the patients with colon adenoma and carcinoma than control subjects. The association between H. pylori infection and colonic diseases is controversial. We evaluated H. pylori infection rate and the related upper gastrointestinal lesions in the patients with colon polyp and cancer. METHODS: Ninety-four subjects, 67 with colonic lesions and 27 without colonic lesions were enrolled. Colon polyp and cancer were confirmed by colonoscopic biopsy or polypectomy. The enrolled subjects were received gastroduodenoscopic examination. H. pylori infection was evaluated serologically and/or with rapid urease test. The fasting serum gastrin level was measured. RESULTS: H. pylori infection rates in the patients with and without colonic lesions were 67.2% and 44.4%, respectively (p<0.05). Upper gastrointestinal lesions were observed in 27 of 67 patients (40.3%) with colonic lesions and in 11 of 27 patients (40.7%) without colonic lesions (p=1.0). Mean levels of serum gastrin with and without colonic lesions were 91.7+/-31.1 pg/mL and 88.1+/-37.7 pg/mL, respectively (p=0.15). CONCLUSIONS: Our study supports the relationship between H. pylori infection, colorectal neoplasia. Although there was no significant difference, the possibility of the simultaneous presence of upper gastrointestinal lesions in the patients with colorectal polyp and cancer was suggested. But the relationship between serum gastrin and the development of colorectal polyp and cancer was not documented.
Adenoma ; Biopsy ; Colon* ; Colonic Diseases ; Colonic Neoplasms ; Fasting ; Gastrins ; Helicobacter pylori* ; Helicobacter* ; Humans ; Polyps ; Prevalence ; Urease

OBJECTIVE: To explore the clinical therapeutic effect of herb-partitioned moxibustion at point in patients of diabetic gastroparesis differentiated as spleen and stomach deficiency and retention of turbid dampness as well as its effect mechanism. METHODS: A total of 134 patients with diabetic gastroparesis were randomized into an observation group and a control group, 67 cases in each one. In the observation group, herb-partitioned moxibustion at point was adopted, 40 min each time, once a day for 5 times a week. In the control group, itopride hydrochloride tablets were prescribed for oral administration, 50 mg each time, three times a day. A total of 6 weeks of treatment was required in the two groups. Before and after treatment, the gastroparesis cardinal symptom index (GCSI) scores, 4-hour gastric emptying rate, TCM symptom score, as well as the levels of plasma motilin and serum gastrin were observed in the patients of the two groups. Additionally, the clinical therapeutic effect was evaluated in the two groups. RESULTS: After treatment, the score of every item of GCSI, TCM symptom scores and the levels of plasma motilin and serum gastrin were all reduced as compared with those before treatment in the patients of the two groups (<0.05), and those in the observation group were lower than the control group (<0.05). Regarding 4-hour gastric emptying rates, which were increased as compared with those before treatment in the two group (<0.05), and the rate in the observation group was higher remarkably than that in the control group (<0.05). The total effective rate was 92.5% (62/67) in the observation group, higher than 74.6% (50/67) in the control group (<0.05). CONCLUSION Herb-partitioned moxibustion at point relieves the clinical symptoms in the patients with diabetic gastroparesis and increases the gastric emptying rate, which is probably related to the regulation of the levels of plasma motilin and serum gastrin.
Acupuncture Points ; Diabetes Mellitus ; Gastric Emptying ; Gastrins ; blood ; Gastroparesis ; therapy ; Humans ; Motilin ; blood ; Moxibustion