4.Heterotopic gastric mucosa with mild dysplasia in the gallbladder.
Yue-long LIANG ; Xiao LIANG ; Yi-fan WANG ; Xiu-jun CAI
Chinese Medical Journal 2013;126(5):978-979
Adult
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Gallbladder Diseases
;
pathology
;
Gastric Mucosa
;
pathology
;
Humans
;
Male
5.Empirical study in the relation of gastric mucosal lesion with gastric emptying and gastric acid secretion.
Hong-feng ZHANG ; Ying-wei XUE
Chinese Journal of Gastrointestinal Surgery 2008;11(5):472-476
OBJECTIVETo study the precise cause and the specific procedure about gastric mucosal lesion in rats with water immersion-restraint stress(WRS).
METHODSOne hundred and forty-four Wistar rats were divided into 9 groups randomly: A, B, C, D, E, F, G, H and I group. There were 16 rats in each group. A, B and C groups underwent gastric emptying determination. Emptying rate of gastric fluid was determined with radiate nuclide (99m)Tc. D, E and F groups underwent gastric acid secretion determination after cleaning gastric contents and pylorus ligation. G, H and I groups underwent gastric acid secretion determination after pylorus ligation without cleaning gastric contents. Gastric mucosal lesion ulcer index(UI) was evaluated. The relationship between of gastric mucosal lesion and gastric emptying rate and gastric acid secretion were examined.
RESULTSGastric emptying rate decreased obviously when the WRS time was prolonged. There were significant differences among B (WRS 2 h), C group (WRS 4 h) and A group (controlled group) (P<0.01). There was also significant difference between B and C group (P<0.01).The rats' gastric acid secretion was inhibited significantly. The differences among E (WRS 2 h), F (WRS 4 h) and D groups (controlled group) were significant (P<0.01). There was no significant difference between F and E groups (P>0.05). The gastric mucosal lesions were aggravated with time of stress. Gastric contents cleaning could effectively prevent gastric mucosal lesions originated by stress .The operation had no influence on this test. There were significant gastric mucosal lesion UI in B and C groups compared with A group (P<0.01). The difference between B and C group was significant (P<0.01).There were no gastric mucosal lesions in A, D, E, F and G groups. However, There was significant difference between I and F group (P<0.01). No significant difference were found among A, D, E, F and G groups (P>0.05). There were significant difference between H and B group and also between I and C group (P<0.01).
CONCLUSIONSWRS can induce gastric emptying disturbance, reduce gastric acid secretion and cause gastric mucosal lesion. As a factor inducing gastric mucosal lesion, acid can damage gastric mucosa as long as it exists without necessary peracid. The prolongation of acid with gastric mucosa contact period and the decrease of gastric mucosa resistance are perhaps the major causes of gastric mucosal lesion. Besides anti-acid, giving facilitative gastric emptying drugs and gastric lavage during stress ulcer prevention and cure should be considered. Acid evacuation in time is also a major cure for gastritis and recurrent ulcer.
Animals ; Gastric Acid ; secretion ; Gastric Emptying ; Gastric Mucosa ; pathology ; Male ; Rats ; Rats, Wistar ; Stress, Physiological
6.Histologic Discrepancy between Gastric Biopsy and Resection Specimen in the Era of Endoscopic Treatment for Early Gastric Cancer.
The Korean Journal of Gastroenterology 2014;64(5):256-259
Endoscopic resection (ER) is accepted as a treatment option for early gastric cancer in patients with negligible risk of lymph node metastasis. Determination of histologic differentiation of adenocarcinoma based on pretreatment endoscopic biopsy is critical in deciding the treatment strategy of ER versus surgical resection. However, discrepancies are frequent between pretreatment biopsies and ER specimens, which may result in an additional gastrectomy after ER. In this context, a review on possible factors contributing to the diagnostic discrepancy in the histologic difference between the pretreatment biopsy and ER is necessary. Two major factors are significantly associated with this discrepancy: pathologic characteristics of the tumor itself, i.e. histologic heterogeneity (tumor factor), and diagnostic procedure performed by endoscopists or pathologists (human factor). In this review, we focus on pathologic report of pretreatment biopsy specimens and its clinical significance.
Adenocarcinoma/*pathology
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Biopsy
;
Cell Differentiation
;
Gastrectomy
;
Gastric Mucosa/pathology
;
Gastroscopy
;
Humans
;
Stomach Neoplasms/*pathology
7.Is Streoscopic Finding Valuable for the Pathologic Diagnosis of Endoscopic Submucosal Dissection Specimen?.
The Korean Journal of Gastroenterology 2010;56(5):334-335
No abstract available.
Adenoma/pathology
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Dissection/*methods
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Gastric Mucosa/*pathology/surgery
;
Gastroscopy/*methods
;
Humans
;
Stomach Neoplasms/pathology/surgery
8.Aberrant Expression and Glycosylation of Mucins in Gastric Mucosal Disease.
Acta Academiae Medicinae Sinicae 2022;44(2):294-298
Mucins,a family of heavily glycosylated proteins,present mainly in epithelial cells.They function as essential barriers for epithelium and play important roles in cellular physiological processes.Aberrant expression and glycosylation of mucins in gastric epithelium occur at pathological conditions,such as Helicobacter pylori infection,chronic atrophic gastritis,intestinal metastasis,dysplasia,and gastric cancer.This review addresses the major roles played by mucins and associated O-glycan structures in normal gastric epithelium.Further,we expound the alterations of expression patterns and glycan signatures of mucins at those pathological conditions.
Gastric Mucosa/pathology*
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Glycosylation
;
Helicobacter Infections/pathology*
;
Helicobacter pylori/metabolism*
;
Humans
;
Mucins/metabolism*
;
Stomach Neoplasms/pathology*
9.Influence of cold exposure on some biochemical indexes and gastrointestinal tract mucosal hyperaemia in hailan chickens.
Chinese Journal of Applied Physiology 2002;18(2):148-158
Animals
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Chickens
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Cold Temperature
;
adverse effects
;
Gastric Mucosa
;
metabolism
;
pathology
;
physiopathology
;
Intestinal Mucosa
;
metabolism
;
pathology
;
physiopathology
;
Male
;
Serum
;
metabolism