Fundic gland hyperplasia is a hyperplasia of glandular portion on epithelium of gastric fundus or body. The incidence of fundic gland hyperplasia is 1.4% in the general population. Fundic gland hyperplasia is the most common cause of multiple polyposis. Probably the most cause of fundic gland hyperplasia is a hamartomatous origin but some hyperplastic origin because of spontaneous remission. We have experienced and reported a case of atypical fundic gland hyperplasia confirmed by endoscopic mucosal resection.
Epithelium ; Gastric Fundus ; Hyperplasia* ; Incidence ; Remission, Spontaneous

Cardia ; Gastric Fundus ; Humans ; Stomach Neoplasms ; surgery

Mucinous adenocarcinoma is a rare histologic type of gastric carcinoma. Most mucinous gastric carcinoma is diagnosed by histology after surgical resection. However, in this report, we preoperatively predicted the type of a tumor (mucinous type) from its characteristic endoscopic finding. An endoscopic examination showed a cauliflower-like mass on the upper body of the posterior wall. At first we could not find the mass because it was covered with a thick mucin-like substance. After gastric lavage and mucin aspiration we found a tumor mass which was surrounded with a characteristic mucin pool. Abdominal CT showed a 6 cm sized-mass connected with the gastric fundus. Total gastrectomy with esophagojejunostomy was performed. The pathology of the tumor proved to be a mucinous adenocarcinoma.
Adenocarcinoma* ; Adenocarcinoma, Mucinous ; Gastrectomy ; Gastric Fundus ; Gastric Lavage ; Gastric Mucins* ; Mucins* ; Pathology ; Tomography, X-Ray Computed

BACKGROUND/AIMS: DA-9701 significantly improved gastric accommodation by increasing the postprandial gastric volume. In this study, we investigated how DA-9701 affects the rat gastric fundus relaxation. METHODS: Gastric fundus muscle strips (9 longitudinal and 7 circular muscles) were obtained from rats. Electrical field stimulation (EFS) was performed at various frequencies (1, 5, 10 and 20 Hz) and train durations (1, 5, 10 and 20 seconds) to select optimal condition for experiments. Isometric force measurements were performed in response to EFS. Peak and nadir were observed during the first 1 minute after initiation of EFS in control state and after sequential addition of atropine (1 microM), DA-9701 (0.5, 5, 25 and 50 microg), N-nitro-L-arginine (L-NNA, 100 microM), MRS2500 (1 microM) and tetrodotoxin (TTX, 1 microM) to the organ bath. RESULTS: The optimal frequency and duration of EFS to evoke nerve-mediated relaxation was determined as 5 Hz for 10 seconds. Addition of L-NNA in the presence of atropine and DA-9701 (50 microg) decreased nadir by inhibiting relaxation from -0.054 +/- 0.021 g to -0.022 +/- 0.015 g (P = 0.026) in longitudinal muscles. However, subsequent application of MRS2500 in the presence of atropine, DA-9701 (50 microg) and L-NNA did not affect nadir. In circular muscles, subsequent addition of L-NNA and MRS2500 in the presence of atropine and DA-9701 (50 microg) did not show significant change of nadir. CONCLUSIONS: Our data suggest that the effect of DA-9701 on the rat gastric fundus relaxation is mainly mediated by nitrergic rather than purinergic pathway.
Animals ; Atropine ; Baths ; Gastric Fundus* ; Muscles ; Rats* ; Relaxation* ; Tetrodotoxin

Reflex gasping when hanging leads to passive and vigorous vomiting, the mechanical force of which causes gastric mucosa laceration. Mallory-Weiss syndrome is a tear in the gastro-esophageal junction or its adjacent mucosa, and this can occur due to nausea or vomiting that is caused by various etiologic factors. Gastric fundus is the most common site of gastric mucosa lacerations. We report a case of a 41-year-old man, who tried to hang himself and, as a result, caused multiple gastric mucosa lacerations that were treated by an endoscopic hemostatic procedure in the emergency room.
Adult ; Emergencies ; Gastric Fundus ; Gastric Mucosa ; Humans ; Lacerations ; Mallory-Weiss Syndrome ; Mucous Membrane ; Nausea ; Reflex ; Vomiting

Humans ; Stomach Neoplasms/pathology* ; Gastric Fundus/pathology* ; Gastric Mucosa/pathology* ; Polyps/pathology*

Humans ; Stomach/pathology* ; Gastric Fundus/pathology* ; Gastric Mucosa/pathology* ; Neoplasms/pathology* ; Stomach Neoplasms/pathology*

Gastritis cystica polyposa (GCP) which is characterized by polypoid hyperplasia of the gastric mucosa, is known as an uncommon lesion that usually occurs at the gastroenterostomy site, although rarely it can be found in an unoperated stomach. Recently, GCP has been proposed to be a possible precancerous lesion itself. We present a rare case of GCP which presented as a large soft polypoid mass with a stalk in a previously unoperated stomach. A 44-year-old woman was admitted due to further study of large gastric mass. Previously, she had not undergone gastric surgery. Physical examination disclosed nothing abnormal. and laboratory test showed iron deficiency anemia. Endoscopy showed a large soft polypoid mass in gastric fundus and endoscopic ultrasonography showed a homogenous hypoechoic, and multilocular cystic mass with a stalk. We removed it via endoscopic polypectomy and histologic examination of this polypoid specimen showed the features consistent with the diagnosis of GCP.
Adult ; Anemia, Iron-Deficiency ; Diagnosis ; Endoscopy ; Endosonography ; Female ; Gastric Fundus ; Gastric Mucosa ; Gastritis* ; Gastroenterostomy ; Humans ; Hyperplasia ; Physical Examination ; Stomach*

The gastric fundus is a rare site for benign ulcer occurrence as it consists of parietal cells, which secret gastric acid. It is resistant to gastric acid and pepsin, and has an abundant blood supply. Varices or other vascular lesions, such as polyps and submucosal tumors, are more frequently found in the gastric fundus. When an ulcer is found in the gastric fundus, it is important to consider underlying conditions such as a malignancy. In this case, a benign gastric ulcer in the gastric fundus dome formed a protruding mass-like lesion with central necrosis, which was reminiscent of a malignant submucosal tumor. Proper follow-up gastroscopy with endoscopic ultrasonography helped to differentiate these similar lesions. We report here a case of a benign gastric ulcer in the fundus dome that was reminiscent of a malignant submucosal tumor, with a review of the literature.
Endosonography ; Follow-Up Studies ; Gastric Acid ; Gastric Fundus ; Gastroscopy ; Necrosis ; Pepsin A ; Polyps ; Stomach Ulcer ; Ulcer ; Varicose Veins

Esophageal and Gastric Varices ; drug therapy ; Gastric Fundus ; drug effects ; Hemorrhage ; drug therapy ; Hemostasis ; Humans ; Plant Extracts ; therapeutic use ; Ultrasonography ; methods