1.Follow-up Management State of Lead Battery Workers in Periodic Health Examination.
Gap Soo LEE ; Young HWANGBO ; Yong Bae KIM ; Hwa Sung KIM ; Jung Oh HAM ; Sung Soo LEE ; Kyu Dong AHN ; Byung Kook LEE ; Jung HUR
Korean Journal of Preventive Medicine 1996;29(4):733-746
To evaluate the follow-up management state and related factor of lead battery workers in periodic health examination as part of program of group occupational health service, author studied 293 workers with questionnaire on knowledge of results and follow-up management state and related factors, and compared the responses to their periodic health examination result charts. The results were as follows: 1. 252(86%) workers responsed that they had received the health examination result chart, but only 116(39.6%) workers responsed that they had been educated or explained about the result of health examination, and 11(57.9%) workers among 19 workers with non-occupational disease D, 101(44.3%) workers among 228 workers with non-occupational disease C, and 19(28.4%) workers among 67 workers with occupational disease C knew accurately their health examination results. 2. 78(24.8%) of the workers responsed that they had follow-up management, and contents of follow-up management were follow-up(36.6%), out-patient treatment(31%), change worksite(8.5%), temporary retirement(7.0%) and others(16.9%). 3. Most of the workers responsed that the health examination were necessary, but three-fourths of the workers responsed that the health examination had been superficial or that they didn't know. 4. In this study, follow-up management show significant association with only explanation or education about health examination result chart.
Education
;
Follow-Up Studies*
;
Humans
;
Knowledge of Results (Psychology)
;
Occupational Diseases
;
Occupational Health Services
;
Outpatients
;
Surveys and Questionnaires
2.Measurement of Interuncal Distance in Mild Cognitive Impairment.
Jin Sook CHEON ; Won Yong CHO ; Gap Soo JEON ; Hae Ran SONG ; Byoung Hoon OH
Journal of Korean Geriatric Psychiatry 2004;8(2):121-126
OBJECTIVES: The hippocampal atrophy has been known to be an important biological marker for the early diagnosis of mild cognitive impairment (MCI). The aims of this study are to disclose the differerence in the interuncal distance (IUD) between MCI, dementia of the Alzheimer's type (DAT) and healthy aged controls, and to identify the affecting factors. METHODS: In transaxial plane, the IUDs at the level of the suprasellar cistern on the T1-weighted images on the brain MRI were measured in patients with MCI (N=30), those with DAT (N=34), and healthy aged controls (N=20). Furthermore, demographic data about age, sex, educational level as well as cerebrovascular factors were obtained by structured interviews and medical records, and the severity of cognitive disorders were assessed using the Mini-Mental Status Examination (MMSE), the Clinical Dementia Rating (CDR) and the Global Deterioration Scale (GDS). RESULTS: 1) The mean (+/-S.D.) IUD of DAT group (26.52+/-3.37 mm) was significantly different from that of healthy aged controls (24.35+/-2.91 mm)(p=0.044). However, there were no significant differences between IUD of MCI group (25.60+/-2.66 mm) and that of DAT group (p=0.483) as well as that of healthy aged controls and that of MCI group (p=0.363). 2) Variables such as age, sex, educational level, cerebrovascular risk factors and severity of cognitive disorder were not related to the IUD. CONCLUSIONS: The measurement of IUD on the brain MRI did not seem to be a helpful biological marker for the early detection of MCI in clinical practice.
Atrophy
;
Biomarkers
;
Brain
;
Dementia
;
Early Diagnosis
;
Humans
;
Magnetic Resonance Imaging
;
Medical Records
;
Mild Cognitive Impairment*
;
Risk Factors
3.Aryl Hydrocarbon Receptor Ligands Indoxyl 3-sulfate and Indole-3-carbinol Inhibit FMS-like Tyrosine Kinase 3 Ligand-induced Bone Marrow-derived plasmacytoid Dendritic Cell Differentiation.
Won Bhin HWANG ; Da Jeong KIM ; Gap Soo OH ; Joo Hung PARK
Immune Network 2018;18(5):e35-
Aryl hydrocarbon receptor (AhR) regulates both innate and adaptive immune responses by sensing a variety of small synthetic and natural chemicals, which act as its ligands. AhR, which is expressed in dendritic cells (DCs), regulates the differentiation of DCs. However, effects of AhR on the differentiation of DCs are variable due to the heterogeneity of DCs in cell surface marker expression, anatomical location, and functional responses. The plasmacytoid DCs (pDCs), one of DC subsets, not only induce innate as well as adaptive immune responses by secreting type I interferons and pro-inflammatory cytokines, but also induce IL-10 producing regulatory T cell or anergy or deletion of antigen-specific T cells. We showed here that AhR ligands indoxyl 3-sulfate (I3S) and indole-3-carbinol (I3C) inhibited the development of pDCs derived from bone marrow (BM) precursors induced by FMS-like tyrosine kinase 3 ligand (Flt3L). I3S and I3C downregulated the expression of signal transducer and activator of transcription 3 (STAT3) and E2-2 (Tcf4). In mice orally treated with I3S and I3C, oral tolerance to dinitrofluorobenzene was impaired and the proportion of CD11c⁺B220⁺ cells in mesenteric lymph nodes was reduced. These data demonstrate that AhR negatively regulates the development of pDCs from BM precursors induced by Flt3L, probably via repressing the expression of STAT3.
Animals
;
Bone Marrow
;
Cell Differentiation
;
Cytokines
;
Dendritic Cells*
;
Dinitrofluorobenzene
;
fms-Like Tyrosine Kinase 3*
;
Immune Tolerance
;
Interferon Type I
;
Interleukin-10
;
Ligands*
;
Lymph Nodes
;
Mice
;
Population Characteristics
;
Receptors, Aryl Hydrocarbon*
;
STAT3 Transcription Factor
;
T-Lymphocytes
;
Vascular Endothelial Growth Factor Receptor-1*
4.The Role of Alcoholics' Insight in Abstinence from Alcohol in Male Korean Alcohol Dependents.
Jong Sung KIM ; Byoung Kang PARK ; Gap Jung KIM ; Sung Soo KIM ; Jin Gyu JUNG ; Mi Kyeong OH ; Jang Kyun OH
Journal of Korean Medical Science 2007;22(1):132-137
This study was performed to examine the relationship between the abstinence results of alcohol dependents after discharge and the level of insight at the time of discharge. 117 male Korean alcohol dependents discharged from a community-based alcohol treatment center were followed up to determine the initial months of abstinence on a successive basis (IMA), total months of abstinence during 12-month period (TMA), and complete abstinence for one full year after discharge. Analyses of abstinence results with adjustment for the differences in baseline characteristics were performed for subjects' insight levels (poor, fair and good). The mean IMA of patients with good insight was significantly (p<0.01) longer than that of patients with poor insight and TMA of patients with good insight was significantly (p<0.001) longer than that of others. Using patients with good insight as the reference, patients with poor insight showed an adjusted odds ratio (OR) of 0.07 (95% confidence interval [CI]=0.01-0.75, p<0.05) for complete abstinence for one full year after discharge and patients with fair insight, adjusted OR of 0.17 (95% CI=0.03-0.81, p<0.05). These results suggest that alcohol dependents' insight could be regarded as a factor related with abstinence.
Temperance/*psychology
;
Middle Aged
;
Male
;
Humans
;
Alcoholism/*psychology
;
Adult
5.Can Carbohydrate-Deficient Transferrin (CDT) Reflect Alcohol Consumption in Korean Male Drinkers?.
Jong Sung KIM ; Mi Kyoung OH ; Sung Soo KIM ; Byoung Kang PARK ; Jin Kyu JUNG ; Kye Chul KWON ; Jong Woo PARK ; Gap Jung KIM
Journal of the Korean Academy of Family Medicine 2005;26(8):451-455
BACKGROUND: It has been suggested that CDT is a potential biological marker in the Western countries to reflect the degree of past alcohol consumption. This study was performed to compare CDT, AST (aspartate transaminase), ALT (alanine transaminase), and GGT (gamma- glutamyl transferase) as a biological marker reflecting drinking amounts in Korean patients. METHODS: The 25 males with moderate drinking(<14 drinks/week) and 26 males with heavy drinking (>21 drinks/week) were studied for the relationships between their weekly drinking amount and the blood levels of CDT, AST, ALT, and GGT. RESULTS: Only CDT was significantly correlated (P=0.001) with weekly drinking amount among heavy drinkers, while both CDT (P=0.029) and GGT (P=0.000) were significantly correlated in moderate drinkers. Stepwise multiple regression revealed that GGT had R2 of 49.1% in moderate drinkers and CDT had R2 of 38.9% in heavy drinkers for the weekly drinking amount. CONCLUSION: The results described above suggested that CDT can be a potential biological marker for the purpose of quantitative monitoring the drinking behavior of heavy drinkers in Korea.
Alcohol Drinking*
;
Biomarkers
;
Drinking
;
Drinking Behavior
;
Humans
;
Korea
;
Male*
;
Transferrin*
6.Casein kinase 2 is a critical determinant of the balance of Th17 and Treg cell differentiation.
Sung Woong JANG ; Soo Seok HWANG ; Hyeong Su KIM ; Keoung Oh LEE ; Min Kyung KIM ; Wonyong LEE ; Kiwan KIM ; Gap Ryol LEE
Experimental & Molecular Medicine 2017;49(9):e375-
Th17 cells promote inflammatory reactions, whereas regulatory T (Treg) cells inhibit them. Thus, the Th17/Treg cell balance is critically important in inflammatory diseases. However, the molecular mechanisms underlying this balance are unclear. Here, we demonstrate that casein kinase 2 (CK2) is a critical determinant of the Th17/Treg cell balance. Both the inhibition of CK2 with a specific pharmacological inhibitor, CX-4945, and its small hairpin RNA (shRNA)-mediated knockdown suppressed Th17 cell differentiation but reciprocally induced Treg cell differentiation in vitro. Moreover, CX-4945 ameliorated the symptoms of experimental autoimmune encephalomyelitis and reduced Th17 cell infiltration into the central nervous system. Mechanistically, CX-4945 inhibited the IL-6/STAT3 and Akt/mTOR signaling pathways. Thus, CK2 has a crucial role in regulating the Th17/Treg balance.
Casein Kinase II*
;
Casein Kinases*
;
Caseins*
;
Central Nervous System
;
Encephalomyelitis, Autoimmune, Experimental
;
In Vitro Techniques
;
RNA, Small Interfering
;
T-Lymphocytes, Regulatory*
;
Th17 Cells
7.Brief Insight-enhancement Intervention among Patients with Alcohol Dependence.
Jin Gyu JUNG ; Jong Sung KIM ; Gap Jung KIM ; Mi Kyeong OH ; Sung Soo KIM
Journal of Korean Medical Science 2011;26(1):11-16
Patients' insight has a critical role in the recovery from problematic behavior. The aim of this study was to evaluate the effects of a brief intervention to promote insight among alcohol-dependent patients. A total of 41 alcohol-dependent patients (30 males, 11 females) in an insight-deficient state who had been admitted to a community-based alcohol treatment center, were randomized into two groups based on their admission order: an intervention group (IG) (n = 20) and a control group (CG) (n = 21). Patients in both the IG and CG participated in an identical treatment program with one exception: patients in the IG were required to undergo five sessions of brief individual intervention focusing on insight enhancement. Changes in insight state were assessed after the intervention. The IG exhibited significant (P < 0.05) changes in the distribution of insight level, while the CG did not exhibit any significant changes in the distribution of insight level. The insight score after intervention was significantly (P < 0.05) greater for the IG than the CG with adjustment for the baseline characteristics. The results suggest that a brief individual intervention focused on insight enhancement may be an effective tool to improve insight among alcohol-dependent patients.
Adult
;
Alcohol-Related Disorders/*therapy
;
Female
;
Humans
;
Interviews as Topic
;
Male
;
Middle Aged
;
Patient Education as Topic
8.Brief Insight-enhancement Intervention among Patients with Alcohol Dependence.
Jin Gyu JUNG ; Jong Sung KIM ; Gap Jung KIM ; Mi Kyeong OH ; Sung Soo KIM
Journal of Korean Medical Science 2011;26(1):11-16
Patients' insight has a critical role in the recovery from problematic behavior. The aim of this study was to evaluate the effects of a brief intervention to promote insight among alcohol-dependent patients. A total of 41 alcohol-dependent patients (30 males, 11 females) in an insight-deficient state who had been admitted to a community-based alcohol treatment center, were randomized into two groups based on their admission order: an intervention group (IG) (n = 20) and a control group (CG) (n = 21). Patients in both the IG and CG participated in an identical treatment program with one exception: patients in the IG were required to undergo five sessions of brief individual intervention focusing on insight enhancement. Changes in insight state were assessed after the intervention. The IG exhibited significant (P < 0.05) changes in the distribution of insight level, while the CG did not exhibit any significant changes in the distribution of insight level. The insight score after intervention was significantly (P < 0.05) greater for the IG than the CG with adjustment for the baseline characteristics. The results suggest that a brief individual intervention focused on insight enhancement may be an effective tool to improve insight among alcohol-dependent patients.
Adult
;
Alcohol-Related Disorders/*therapy
;
Female
;
Humans
;
Interviews as Topic
;
Male
;
Middle Aged
;
Patient Education as Topic
9.Assessment of Quality of Life in Patient with Toenail Onychomycosis in Korea.
Baik Kee CHO ; Jong Gap PARK ; Hyung OK KIM ; Sung Wook KIM ; Seung Chul BAEK ; Jin Wou KIM ; Si Yong KIM ; Kyu Joong AHN ; Jae Bok JUN ; Chee Won OH ; Nack In KIM ; Kyu Suk LEE ; Chil Hwan OH ; Soo Nam KIM ; Sang Tae KIM ; Sook Ja SON ; Yong Woo CHINN ; Dong Seok KIM ; Won Woo LEE ; Kyung Sool KWON ; Dae Hun SUH ; Kyu Uang WHANG ; Jong Suk LEE ; Jai Kyoung KOH ; Won Hyoung KANG ; Kee Yang CHUNG ; Eung Ho CHOI ; Ki Hong KIM ; Seok Don PARK ; Seung Joo KANG ; Jeong Hee HAHM ; Ki Bum MYUNG ; Bang Soon KIM ; Sang Wahn KOO ; Byung Su KIM ; Young Ho WON ; Han Uk KIM ; Eun Sup SONG ; Byoung Soo CHUNG ; Chang Kwun HONG ; Byung In RO ; Jang Kyu PARK ; Jee Yoon HAN ; Kwang Joong KIM ; Dae Won KOO ; Jong Min KIM ; Jae Hong KIM ; Hee Joon YU ; Kyung Mee YANG
Korean Journal of Medical Mycology 1998;3(2):115-124
BACKGROUND: Onychomycosis, especially toenail onychomycosis has become one of the common fungal infection and has historically been regarded as a cosmetic rather than medical problem by many patients, even by physicians. Recently, however, there are several reports that this is a refractory disease which may cause a deleterious effect on patients' quality of life (QOL). OBJECTIVE: The purpose of this study was to investigate the impact of toenail onychomycosis on QOL in Korea and to assess the changes of QOL after treatment. METHODS: Total 1004 patients with toenail onychomycosis which was confirmed by clinical findings and KOH preparation were enrolled at 47 dermatologic centers in Korea, and interviewed with standardized QOL questionnaire before and after systemic antifungal treatment. Responses to the questionnaire were scored by f-point scale (0~4) and averaged, and were analyzed for 5 dimensions of emotional impact, social impact, symptom and functional impact, patients' views concerning treatment, and relationship with doctor. RESULTS: 1. Before and after treatment, the most serious impact was emotional dimension showing 1.90 and 1.30 in average score (AS), and social (AS: 1.14 and 0.83) and symptom and functional impact (AS: 1.05 and 0.92) was also affected. 2. In female rather than male, statistically more significant impact on patients' QOL was observed in all dimensions. 3. After treatment, 3 of 5 dimensions were improved significantly - emotional dimension (AS: from 1.90 to 1.30), social dimension (AS: from 1.14 to 0.83), patients' view concerning treatment(AS: from 1.34 to 1.02) 4. The degree of patients' satisfaction at the therapeutic effect was very high - 62.4% (immediately after. treatment) and 65.8% (9 months after initiation of treatment) of patients answered excellent or good. CONCLUSION: This study confirms that toenail onychomycosis has significant Impact on the overall QOL of patients. Also the effect of antifungal therapy on patients' QOL were satisfactory. Therefore, both doctor and patient should pay more attention to the treatment of onychomycosis.
Female
;
Humans
;
Korea*
;
Male
;
Nails*
;
Onychomycosis*
;
Quality of Life*
;
Social Change
;
Surveys and Questionnaires