1.The Study of the Effect on s-GOT, s-GPT after the Enflurane Auesthesia.
Gap Soo KWON ; In Sook YANG ; In Ho HA
Korean Journal of Anesthesiology 1984;17(4):255-262
In order to observe the effect on liver function after exposure to enlurane which has relatively minimal hepatotoxic effect, we evaluated the changes of the s-GOT & s-GPT levels caused by general anesthesia with enflurane. This study was undertaken to evaluate the effect of enflurane on liver function by comparing the preoperative and postoperative(1st day, 3rd day, 5th day, and 7th day) liver function(s-GOT & s-GPT) tests is il cases of the first general anesthesia with enflurane and 15 cases of a second general anesthesia with enflurane. The results were as folllows: 1) The 1st operative group. a. There are 5 cases (45%) of significant changes of s-GOT levels and no case of significant change in sGPT levels. b. In most of cases, the level of s-GOT & s-GPT have returned to normal values on the 7th postoperative day. 2) The 2nd operative group. a. The increase in the levels of s-GOT was found in 10 cases, and the s-GPT in 6 cases. b. Postoperatively, the simultaneous increase in the levels of s-GOT & s-GPT were found in 4 cases. c. On the 7th postoperative day, the levels of s-GOT & s-GPT was not normal in 3 cases, and not normal for s-GPT in 2 cases. The above results show that the higher of levels of s-GOT & s-GPT after the second general anesthesia with enflurane apparent compared to the levels after the first general anesthesia with enflurane. And it can be assumed that the extreme precaution is necessary in conduction the second general anesthesia with enflurane.
Alanine Transaminase
;
Anesthesia, General
;
Enflurane*
;
Liver
;
Reference Values
2.Forskolin Changes the Relationship between Cytosolic Ca2+ and Contraction in Guinea Pig Ileum.
Koon Hee HAN ; Gap Jin CHEON ; Dong Soo YEON ; Seong Chun KWON
The Korean Journal of Physiology and Pharmacology 2009;13(3):189-194
This study was designed to clarify the mechanism of the inhibitory effect of forskolin on contraction, cytosolic Ca2+ level ([Ca2+]i), and Ca2+ sensitivity in guinea pig ileum. Forskolin (0.1 nM~10 micrometer) inhibited high K+ (25 mM and 40 mM)- or histamine (3 micrometer)-evoked contractions in a concentration-dependent manner. Histamine-evoked contractions were more sensitive to forskolin than high K+-evoked contractions. Spontaneous changes in [Ca2+]i and contractions were inhibited by forskolin (1 micrometer) without changing the resting [Ca2+]i. Forskoln (10 micrometer) inhibited muscle tension more strongly than [Ca2+]i stimulated by high K+, and thus shifted the [Ca2+]i-tension relationship to the lower-right. In histamine-stimulated contractions, forskolin (1 micrometer) inhibited both [Ca2+]i and muscle tension without changing the [Ca2+]i-tension relationship. In alpha-toxin-permeabilized tissues, forskolin (10 micrometer) inhibited the 0.3 micrometer Ca2+-evoked contractions in the presence of 0.1 mM GTP, but showed no effect on the Ca2+-tension relationship. We conclude that forskolin inhibits smooth muscle contractions by the following two mechanisms: a decrease in Ca2+ sensitivity of contractile elements in high K+-stimulated muscle and a decrease in [Ca2+]i in histamine-stimulated muscle.
Animals
;
Contracts
;
Cytosol
;
Forskolin
;
Guanosine Triphosphate
;
Guinea
;
Guinea Pigs
;
Histamine
;
Ileum
;
Muscle Tonus
;
Muscle, Smooth
;
Muscles
3.Can Carbohydrate-Deficient Transferrin (CDT) Reflect Alcohol Consumption in Korean Male Drinkers?.
Jong Sung KIM ; Mi Kyoung OH ; Sung Soo KIM ; Byoung Kang PARK ; Jin Kyu JUNG ; Kye Chul KWON ; Jong Woo PARK ; Gap Jung KIM
Journal of the Korean Academy of Family Medicine 2005;26(8):451-455
BACKGROUND: It has been suggested that CDT is a potential biological marker in the Western countries to reflect the degree of past alcohol consumption. This study was performed to compare CDT, AST (aspartate transaminase), ALT (alanine transaminase), and GGT (gamma- glutamyl transferase) as a biological marker reflecting drinking amounts in Korean patients. METHODS: The 25 males with moderate drinking(<14 drinks/week) and 26 males with heavy drinking (>21 drinks/week) were studied for the relationships between their weekly drinking amount and the blood levels of CDT, AST, ALT, and GGT. RESULTS: Only CDT was significantly correlated (P=0.001) with weekly drinking amount among heavy drinkers, while both CDT (P=0.029) and GGT (P=0.000) were significantly correlated in moderate drinkers. Stepwise multiple regression revealed that GGT had R2 of 49.1% in moderate drinkers and CDT had R2 of 38.9% in heavy drinkers for the weekly drinking amount. CONCLUSION: The results described above suggested that CDT can be a potential biological marker for the purpose of quantitative monitoring the drinking behavior of heavy drinkers in Korea.
Alcohol Drinking*
;
Biomarkers
;
Drinking
;
Drinking Behavior
;
Humans
;
Korea
;
Male*
;
Transferrin*
4.Early Avascular Necrosis of the Femoral Head: Relationship of the Findings of Preoperative MRI and the Long-Term Results of Core Decompression.
Dal Soo PARK ; Soon Tae KWON ; Dong Kweon JEON ; Gun Young JEONG ; Hong Lim JANG ; Sang Ho LEE ; Eun Hee PARK ; Chung Gun LEE ; Moon Gap SONG ; Jung Eun KIM ; Yang Hee PARK
Journal of the Korean Radiological Society 1997;37(4):745-750
PURPOSE: To evaluate potential correlation between the extent and site of avascular necrosis (AVN), as determined by preoperative magnetic resonance (MR) imaging, and the development of femoral head collapse. MATERIALS AND METHODS: Using clinical, radiographic and MR imaging criteria, twenty hips in 15 patients were selected for core decompression. Preoperative MR results were classified into three categories: group A, less than 15% involvement of the weight-bearing portion of the femoral head; group B, 15%-30% involvement; group C, more than 30% involvement, according to ARCO staging. We also established three groups according to site of involvement of the femoral head, namely medial, middle and lateral. RESULTS: Of 20 cases, three were stage Ia; two, Ib; four, Ic; three, IIa; two, IIb; and 6, IIc. Ten cases of Ia, Ib, IIa or IIb showed no femoral head collapse during follow-up of at least 24 months, while ten cases of Ic or IIc showed femoral head collapse. CONCLUSION: The prognosis of core decompression in patients with early AVN is related to the area of lesion in the femoral head.
Decompression*
;
Follow-Up Studies
;
Head*
;
Hip
;
Humans
;
Magnetic Resonance Imaging*
;
Necrosis*
;
Prognosis
;
Weight-Bearing
5.A case of giant cavernous hemangioma of the adrenal gland.
Byung Il KIM ; Woon Chul YOE ; Gi Sup LEE ; Hong Sup LIM ; Jong Min HONG ; Kil Jong YOU ; Myung Jun KIM ; Dong Il BYUN ; Jae Gap LEE ; Gook Hwan KWON ; Soo Nam LEE
Korean Journal of Medicine 2000;59(3):310-313
Cavernous hemangiomas are unusual tumors with a propensity for skin and liver involvement and rarely involving adrenal gland.Adrenal hemangiomas are nonfunctioning tumors, usually discovered at autopsy. In 1955, Johnson and Jeppensen reported the first adrenal hemangioma to be removed surgically.One case of emangioma of the adrenal gland was reported in Korea. We report a case of a cavernous hemangioma of the adrenal gland which was successfully treated surgically.In addition, we review the clinical, radiographic, and pathologic features of this disease. With the advance of diagnostic thchniques in arterography, ultrasound, and computerized tomography, preoperative recognition and diagnosis should be simplified and surgical removal carried out to rule out possible malignancy, preclude traumatic rupture, or relieve symptoms of the mass.
Adrenal Glands*
;
Autopsy
;
Diagnosis
;
Hemangioma
;
Hemangioma, Cavernous*
;
Korea
;
Liver
;
Rupture
;
Skin
;
Ultrasonography
6.Assessment of Quality of Life in Patient with Toenail Onychomycosis in Korea.
Baik Kee CHO ; Jong Gap PARK ; Hyung OK KIM ; Sung Wook KIM ; Seung Chul BAEK ; Jin Wou KIM ; Si Yong KIM ; Kyu Joong AHN ; Jae Bok JUN ; Chee Won OH ; Nack In KIM ; Kyu Suk LEE ; Chil Hwan OH ; Soo Nam KIM ; Sang Tae KIM ; Sook Ja SON ; Yong Woo CHINN ; Dong Seok KIM ; Won Woo LEE ; Kyung Sool KWON ; Dae Hun SUH ; Kyu Uang WHANG ; Jong Suk LEE ; Jai Kyoung KOH ; Won Hyoung KANG ; Kee Yang CHUNG ; Eung Ho CHOI ; Ki Hong KIM ; Seok Don PARK ; Seung Joo KANG ; Jeong Hee HAHM ; Ki Bum MYUNG ; Bang Soon KIM ; Sang Wahn KOO ; Byung Su KIM ; Young Ho WON ; Han Uk KIM ; Eun Sup SONG ; Byoung Soo CHUNG ; Chang Kwun HONG ; Byung In RO ; Jang Kyu PARK ; Jee Yoon HAN ; Kwang Joong KIM ; Dae Won KOO ; Jong Min KIM ; Jae Hong KIM ; Hee Joon YU ; Kyung Mee YANG
Korean Journal of Medical Mycology 1998;3(2):115-124
BACKGROUND: Onychomycosis, especially toenail onychomycosis has become one of the common fungal infection and has historically been regarded as a cosmetic rather than medical problem by many patients, even by physicians. Recently, however, there are several reports that this is a refractory disease which may cause a deleterious effect on patients' quality of life (QOL). OBJECTIVE: The purpose of this study was to investigate the impact of toenail onychomycosis on QOL in Korea and to assess the changes of QOL after treatment. METHODS: Total 1004 patients with toenail onychomycosis which was confirmed by clinical findings and KOH preparation were enrolled at 47 dermatologic centers in Korea, and interviewed with standardized QOL questionnaire before and after systemic antifungal treatment. Responses to the questionnaire were scored by f-point scale (0~4) and averaged, and were analyzed for 5 dimensions of emotional impact, social impact, symptom and functional impact, patients' views concerning treatment, and relationship with doctor. RESULTS: 1. Before and after treatment, the most serious impact was emotional dimension showing 1.90 and 1.30 in average score (AS), and social (AS: 1.14 and 0.83) and symptom and functional impact (AS: 1.05 and 0.92) was also affected. 2. In female rather than male, statistically more significant impact on patients' QOL was observed in all dimensions. 3. After treatment, 3 of 5 dimensions were improved significantly - emotional dimension (AS: from 1.90 to 1.30), social dimension (AS: from 1.14 to 0.83), patients' view concerning treatment(AS: from 1.34 to 1.02) 4. The degree of patients' satisfaction at the therapeutic effect was very high - 62.4% (immediately after. treatment) and 65.8% (9 months after initiation of treatment) of patients answered excellent or good. CONCLUSION: This study confirms that toenail onychomycosis has significant Impact on the overall QOL of patients. Also the effect of antifungal therapy on patients' QOL were satisfactory. Therefore, both doctor and patient should pay more attention to the treatment of onychomycosis.
Female
;
Humans
;
Korea*
;
Male
;
Nails*
;
Onychomycosis*
;
Quality of Life*
;
Social Change
;
Surveys and Questionnaires