Objective To evaluate the value of routine head CT scan in diagnosing the fracture of orbital medial wall.Methods 40 cases doubted with the fracture of orbital medial wall were additionally scanned with orbital CT.Results Of 45 cases,35 cases were confirmed with fracture of orbital medial wall.The fracture signs on routine head CT included invagination of orbital medial wall,thick of medial rectus,increase in ethmoid sinus density and intra orbital gas.Conclusion Routine head CT scan can serve as diagnosing or screening the fracture of orbital medial wall.

Objective: To investgate the role of Toll-like receptor(TLR) 2 and TLR4 in pathogenesis of atopic dermatitis(AD) and the effect of topical tacrolimus ointment on expression of TLR2 and TLR4 in lesional AD skin.Methods: Immunohistochemistry was employed to study the expression of TLR2 and TLR4 in normal skin and lesional AD skin before and after using topical tacrolimus ointment.Results: The basal keratinocytes in normal skin constitutively expressed TLR2 and TLR4. In contrast,lesional epidermis from 9 patients with acute AD overexpressed TLR2 and TLR4 on the whole epidermis keratinocytes with membranous and cytoplasmic staining pattern.After using topical tacrolimus ointment for three weeks,TLR2 and TLR4 were expressed on basal and suprabasal keratinocytes with membranous and cytoplasmic staining pattern.Conclusion: These data suggest that TLR2 and TLR4 expressed by epidermal keratinocytes constitute part of the innate immune system of the skin,and increased TLR2 and TLR4 expression may be related to the skin innate immuno-inflammatory response in atopic dermatitis.Topical tacrolimus may directly or indirectly inhibit or downregulate TLR2 and TLR4 expression in KC and inhibit skin innate immuno-inflammatory response related to TLR-NF?B signal transduction and regulation in atopic dermatitis.

Aim To investigate the effect of SM-1 on seven main cytochrome P450(CYP450)in human liver microsomes.Methods Substrate or SM-1 was incubated with human liver microsomes for 30 min in vitro,and divided into control group and experimental group.The effects of SM-1 on the main phase I metabolic enzymes in human liver microsomes was detected by HPLC.Phenacetin,bupropion,paclitaxel,tolbutamide,omeprazole,dextromethorphan,testosterone were investigated as probe drugs.Results Inhibition rate of SM-1 on the classical substrate of human liver microsomal CYP was 0.05％,3.37％,0.08％,2.07％,4.20％,-0.15％and 10.84％,respectively.Conclusions SM-1 may have inhibitory effect on CYP3A4.Attention should be paid to the interaction of clinical drug induced by CYP enzyme inhibition.