Objective To study the feasibility of using heat and moisture exchangers (HME)as an alternative to heated humidifiers (HH) in patients undergoing mechanical ventilation. Methods 266 pa-tients with mechanical ventilation admitted to our ICU over the recent 3 years were allocated to the experi-mental group (humidification with a heat and moisture exchanger) and the control group (with heated hu-midifier), and the effect of humidification, the reserved time of artificial airway, the time on mechanical yen-tilation, the time of stay in ICU, the ineidenee of ventilator-associated pneumonia (VAP) and the mor-tality rate were comparatively studied and analyzed. Results Significant differences were found between the experimental and the control group in effect of humidification, insufficiency of humidification or excessive hu-midification, airway spasm and time on mechanical ventilation and time of stay in ICU. The incidence of VAP in the control group was significantly higher than that in the experimental group. There were no significant dif-ference between the two groups in the reserved time of artificial airway and the mortality rate. There were no accident of humidification occurred in the experimental group while there were one case complicated with air-way burn and 11 eases complicated with choking with water in the control group. Conclusions We conclude that HH can be replaced by HME on mechanical ventilation while disease evolution and effect of humidification should be monitored closely and keep HME unobstructed.

Objective To investigate the association between chewing ability and frailty in elder-ly adults in communities of China.Methods A total of 12,678 elderly people in community were selected from data of Chinese Longitudinal Healthy Longevity and Happy Family Study(CLHLS-HF)as the study subjects.Multivariate Logistic regression analysis was used to explore the relationship be-tween chewing ability and frailty of elderly people in community,and restricted cubic spline(RCS)based on Logistic regression analysis was used to analyze the dose-response relationship between the number of teeth and frailty risk in elderly people in community of China.Results Of the 12,678 community-dwelling older adults,the mean age was(83.62±11.16)years,with an age ranging from 65 to 117 years;there were 5,848(46.1％)men and 6,830(53.9％)women.The results of the multifactorial Logistic regression analysis showed that after adjusting for the covariates including gender,age,marital status,place of residence,ethnicity,living arrangement,years of education,healthcare availability and occupation before age of 60,self-rated economic status,body mass index(BMI),smoking status,alcohol consumption status,exercise status,self-rating health status varia-bles,and participation in the annual medical check-ups or not,the results showed that the chewing a-bility of community-dwelling older adults was associated with the risk of frailty(P＜0.05).The RCS plot showed a linear correlation between the number of natural teeth and the risk of frailty,with the risk of frailty increasing when the number of natural teeth was less than 10,and the risk of frailty gradually increased as the number of teeth decreased.Conclusion Chewing ability is associated with the risk of frailty in Chinese older adults,and the number of natural teeth and the use of dentures are impor-tant for the development of frailty in older adults.

Objective To investigate the association between chewing ability and frailty in elder-ly adults in communities of China.Methods A total of 12,678 elderly people in community were selected from data of Chinese Longitudinal Healthy Longevity and Happy Family Study(CLHLS-HF)as the study subjects.Multivariate Logistic regression analysis was used to explore the relationship be-tween chewing ability and frailty of elderly people in community,and restricted cubic spline(RCS)based on Logistic regression analysis was used to analyze the dose-response relationship between the number of teeth and frailty risk in elderly people in community of China.Results Of the 12,678 community-dwelling older adults,the mean age was(83.62±11.16)years,with an age ranging from 65 to 117 years;there were 5,848(46.1％)men and 6,830(53.9％)women.The results of the multifactorial Logistic regression analysis showed that after adjusting for the covariates including gender,age,marital status,place of residence,ethnicity,living arrangement,years of education,healthcare availability and occupation before age of 60,self-rated economic status,body mass index(BMI),smoking status,alcohol consumption status,exercise status,self-rating health status varia-bles,and participation in the annual medical check-ups or not,the results showed that the chewing a-bility of community-dwelling older adults was associated with the risk of frailty(P＜0.05).The RCS plot showed a linear correlation between the number of natural teeth and the risk of frailty,with the risk of frailty increasing when the number of natural teeth was less than 10,and the risk of frailty gradually increased as the number of teeth decreased.Conclusion Chewing ability is associated with the risk of frailty in Chinese older adults,and the number of natural teeth and the use of dentures are impor-tant for the development of frailty in older adults.