Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerged human coro-navirus causing serious respiratory syndrome. The etiological and epidemiological characteristics of MERS along with the recent advances in MERS will be briefly described in this review.

Objective To investigate the typing profiles of human adenovirus infection among children with severe acute respiratory infection ( SARI ) in Shanghai. Methods A total of 441 nasopharyngeal aspirates ( NPAs) were collected from hospitalized children with SARI in Shanghai Pediatrics Hospital Affiliated Fudan University from June 2013 to March 2014.Human adenovirus was detected by nested PCR followed molecular typing by sequencing.Then the phylogenetic and epidemiological analysis was conducted.Results From 441 hospitalized children with SARI, 51 of samples ( 11.6%, 95%CI:8.6%~14.6%) were detected as HAdV infection.Most of the SARI children with HAdV infection were distributed between 0.5 to 5 years old.Typing data shown that HAdV-B (17 of HAdV-3, 16 of HAdV-7) was most dominant as 64.7%(33/51),followed by HAdV-C as 27.5%(14/51);either HAdV-D (HAdV-8) or HAdV-E ( HAdV-4 ) contained only one case, and HAdV-F ( HAdV-41 ) found in two cases. Conclusion Multiple species( B-F) of HAdVs were circulated among children with SARI in Shanghai, and HAdV-B (HAdV-3, HAdV-7) was the most predominant species of circulation.