OBJECTIVE:To synthesize N-(2, 6-Diethylphenylcarbamoylmethyl) iminodiacetic acid(Etifenin),a precursor of hepa to-biliary imaging agent.METHOD:Target molecular was synthesized fro m 2,6-diethylaniline,with the improved processes.Chemical structures of products were confirmed by IR,1HNMR,and　13CNMR.RESULTS:This syn thetic route is simpler,the yield is higher than those of documents reported.CONCLUSION:This synthetic route is practical.

Objective: To compare nephrotoxicity and ototoxicity of gentamycin administered in single dose or multiple dose daily in guinea pigs. Methods: Thirty two male guinea pigs were divided into physiological saline control, single dose group daily (gentamycin, 120 mg/kg, 1/d) and multiple dose group daily (gentamycin, 60 mg/kg, 2/d). The physiopathology of renal and cochlea in guinea pigs were examined using auditory brainstem response (ABR), SC sound irritation and electron microscope. The gentamycin concentrations in serum and in perilymph were monitored by fluorescene polarization immunoassay (FPIA). Results: (1) Compared with control group, both gentamycin single and mulitiple daily doses injuried kidney and cochlea to some extent.The injury of multiple dose groups were worse than that the single dose groups ( P