Objective To explore the effect of trauma control concept on severe multiple injuries.Methods From March 2016 to March 2018,74 emergency patients with severe multiple injuries were selected in Yiwu Central Hospital.The patients were divided into the observation group and the control group according to the digital table method,with 37 cases in each group.The control group was treated with one-time surgical treatment,and the observation group was given treatment measures for severe multiple trauma in emergency department under the concept of trauma control.The recovery time of body temperature,the recovery time of prothrombin (PT),the time of shock correction,the occurrence of complications,and the therapeutic effect were compared between the two groups.Results The body temperature recovery time,PT recovery time and shock correction time in the observation group were (6.73 ± 3.29) h,(5.18 ± 1.89) h and (5.84 ± 3.14) h,respectively,which were shorter than those in the control group [(9.85 ± 1.62) h,(9.86 ± 2.41) h,(8.45 ± 0.87) h],and the differences were statistically significant (t =5.175,9.295,4.873,all P ＜0.05).The incidence rate of complications in the observation group was 8.11％ (3/37),which was lower than that in the control group [32.43％ (12/37)],the difference was statistically significant(x2 =6.773,P ＜ 0.05).The cure rate of the observation group was 97.30％ (36/37),which was higher than that of the control group [91.89％ (34/37)],but there was no statistically significant difference (P ＞ 0.05).Conclusion The treatment effect of severe multiple injuries under the concept of trauma control is obvious.It is an effective and feasible method,which can effectively reduce the complications and fatality rate.

Objective To investigate the effect of PHD2/HIF-1 signaling pathway on the renal interstitial fibrosis,and the intervention effect of medicated serum of Liuwei Dihuang Tang on HK-2 cells induced by hypoxia.Methods A total of 40 SPF male SD rats were divided into blank group and medicated group(each n=20).The blank group was orally given normal saline 〔10 mL/(kg· d)〕 and medicated group was orally given Liuwei Dihuang Tang for 1 week continuously, and then blood samples were collected from rat abdominal aorta for separating serum after centrifugation.HK-2 cells were cultured in vitro.HK-2 cells were divided into blank control group(10% of fetal bovine serum), normal group (10%of normal serum),CoCl2group(150 μmol/L of CoCl2+10% of normal serum)and medicated serum group(150 μmol/L of CoCl2+10% of medicated serum of Liuwei Dihuang Tang).HK-2 cells were cultivated in vitro and treated in all groups for 24 h,and then the influence of medicated serum of Liuwei Dihuang Tang on protein levels and mRNA expressions of PHD 2, HIF-1αand connective tissue growth factor(CTGF)in HK-2 cells were detected,respectively,by using Western blotting method and reverse transcription polymerase chain reaction(RT-PCR).Results Compared with normal group, the protein level and mRNA expression of PHD 2 in HK-2 cells all decreased(P <0.05), while protein levels of HIF-1αand CTGF and mRNA expressions of HIF-1αand CTGF increased(P<0.05)in CoCl2 group.Compared with CoCl 2group, the protein level and mRNA expression of PHD2 increased(P<0.05),and those of HIF-1αand CTGF decreased(P<0.05)in medicated serum group.Conclusion PHD2/HIF-1αsignal pathway takes part in RIF, and Liuwei Dihuang Tang can inhibit RIF through up-regulating PHD2 expression,improving HIF-1αdegradation and down-regulating CTGF expression.