Objective To explore the effects of early rehabilitation on premature infant with brain damage. Methods101 premature infants with brain damage in were divided into experimental group （n=45） and control group （n=56）. The experimental group received medicine and early rehabilitation. The control group received medicine only. Developmental evaluation were performed in 3, 6, 9, and 12 months old. ResultsThere were no significant differences of the Neonatal Behavioral Neurological Assessment (NBNA) scores between these two groups （P＞0.05）. Except infants of 3 months old, the developmental quotient (DQ) and mental index (MI) of 9, 12 months old infants of the experimental group were higher than that of the control group （P＜0.01）. The sequelae of the experimental group were less than that of the control group （P＜0.05）. ConclusionEarly rehabilitation can promote development of premature infant with brain damage and reduce the sequelae.

Objective:To observe the effects of rosiglitazone on transforming growth factor-?1(TGF-?1)/SMADs signal pathway in dia- betic rat myoeardium(DM)and cardiac remodeling. Methods:Thirty male SD rats were randomly divided into normal control,DM and rosiglitazone groups,each having 10 rats.Diabetic rats were induced by a single intrapefitoneal injection of streptozotoein(60mg/kg).A cannula connected to a trans- ducer was inserted into the heart to measure the cardiac function.The body weight,heart weight and heart weight/body weight (HW/BW)were measured.The ultrastruetural changes were evaluated by electron microscope and collagen content was assessed by Van Gieson staining.The mRNA expression level of SMAD3 and SMAD7 were determined by RT-PCR.The protein level of TGF-?1,SMAD3 and SMAD7 were detected by immunohistochemistry. Results:Compared with the normal controls,diabetic rats experienced marked myocardium damage.Cardiac function,espe- cially diastolic function was impaired,HW/BW(P

The pathogenesy of diabetic peripheral neuropathy(DPN) is approached according to collaterals diseases theory in this study,indicated that defi ciency of both vital energy and yin is the chief pathologic foundation and obstruction of collaterals by blood stasis and phlegm is the critical element in DPN.Furthermore,highlight of differentiation of symptoms and signs,therapeutic principle and diagnosis and treatment based on differentiation are illuminated.This study has supplied a new idea for precaution and treatment of DPN.

Objective To observe the effects of telmisartan on cogtive function and the expression of Ghrelin receptors,growth hormone secretagogues receptor(GHSR) in diabetic rats. Methods Forty rats were randomly divided into 3 groups: control group,diabetic model group,and telmisartan treatment group. Streptozotocin-induced diabetic rat model(65 mg/kg,ip) was established. In the telmisartan treatment group,the rats were treated with telmisartan (13.3 mg?kg-1?d-1) for 12 weeks. Learning and memory abilities of the rats were tested by the Morris water maze. The mRNA and protein levels of GHSR in frontal cortex were detected by RT-PCR and immunohistochemistry. Results Compared with the diabetic model group,the telmisartan treatment group showed a significant decrease in the mean time of escape latencies(P

OBJECTIVE:To establish the method for the determination of plasma concentration of magnesium isoglycyrrhiz-inate in portal vein and peripheral venous blood of patients underwent liver resection,to further validate and evaluate pharmacoki-netic characteristics,rational and safe use of drugs in the clinic. METHODS:31 patients underwent liver resection in our hospital during Oct. 2014-Mar. 2015 were given magnesium isoglycyrrhizinate intravenously at the beginning of surgery. Portal vein and pe-ripheral venous blood of patients were drawn at 1 hour after drug use,and HPLC-UV detection method was used to determine the plasma concentration of drug. RESULTS:The retention time of isoglycyrrhizinate magnesium was 4.5 min,which showed a good peak shape,and was not interfered with the determination by plasma endogenous peak. The plasma concentration ranged from 0.55 to 55.00 mg/L. The minimum quantitative concentration was 0.55 mg/L. The extraction recoveries were 84.7%-87.1%,and method recoveries were 101.2%-105.4%,and RSDs of intra-day and inter-day were less than 6%. Plasma concentration of magnesium iso-glycyrrhizinate in portal vein blood was significantly higher than in peripheral vein blood of patients underwent liver resection (close to 2 times);and plasma concentration was not affected by primary liver diseases and underlying diseases such as cirrhosis. CONCLUSIONS:The method is simple and has high recovery rate of extraction,high accuracy and high sensitivity. It can meet the needs of pharmacokinetic study. After the application of magnesium isoglycyrrhizinate during liver resection,there is higher blood concentration of magnesium isoglycyrrhizinate in portal vein,which is beneficial to protect liver cells and improve liver func-tion. It is suitable during perioperative period of liver.

Objective To investigate the prevalence and risk factors of overweight/obesity and their relationship with dyslipidemia among aerospace professional staff,to provide evidence for more effective health management.Methods Nine hundred eighty aerospace professional staff who took health checkup at our center in 2012 were required to complete a self-report life style questionnaire.Height,body weight and blood lipid profiles of the participants were then measured.Logistic regression was used for data analysis.Results A total of 776 valid questionnaires were finally received.The prevalence of overweight or obesity of the participants were 34.4％ and 10.1％,respectively.Standardized overweight rate was 36.9％ or 36.3％,and standardized obesity rate was 12.3％ or 11.8％,according to Chinese adults' level in 2002 or Beijingers' figure in 2006.Univariate logistic regression showed that age (odds ratio (OR) 2.050,1.666 and 2.164; 95％ confidence interval (CI) 1.490 to 2.820,1.048 to 2.648 and 1.164 to 4.020),gender (OR =0.296,95 ％ CI 0.211 to 0.416),marital status (OR =2.178,95 ％ CI 1.591 to 2.980),cigarette smoking (OR =2.571 and 1.889; 95％ CI 1.061 to 6.229 and 1.341 to 2.660) and alcohol consumption (OR =1.547 and 1.796; 95％ CI0.570 to 4.195 and 1.319 to 2.447) were risk factors of overweight and obesity.In multivariate logistic regression,age (OR =1.562,1.775 and 2.206; 95％ CI 1.029 to 2.372,0.943 to 3.341 and 0.977 to 4.978),female (OR =0.311,95％ CI0.206 to 0.469),marital status (OR =1.591,95％ CI 1.045 to 2.421),meat intake (OR=0.663,95％ CI0.437 to 1.007) and fried food (OR =0.604,95％ CI 0.420 to 0.870) were risk factors of overweight/obesity.The risk of developing hypercholesterolemia,hypertriglyceridemia,low high-density lipoprotein hypercholesterolemia,high lowdensity lipoprotein hypercholesterolemia and hypercholesterolemia were significantly increased in overweight/obese adults.Conclusion Higher prevalence of overweight/obese may alarm the need for aerospace professional staff to initiate body weight control and risk factor prevention,especially for male and married adults.

Aim:To predict ability of self-care at discharge of inpatients with first-ever cerebral infarction. Method: 346 stroke patients with first-ever cerebral infarction admitted to our hospital were analyzed,male 187,female 159,the average age was 63. 90± 11. 40 years and the average length of stay 36. 53±27.03days. Patients were divided into two groups, self-care and non self-care according to discharged outcome.Nineteen factors were selected from casenote and reports of laboratory and special exam such as EKG,CT or/and MRI. All material were analyzed (t test and X2 test,multiple regression). Result:The age in single factor analysis (P<0. 01)and six factors in regression analysis were significant differences in predicting discharged outcome between two groups. Conclusion:Main factors to predict the ability of self-care at discharge of inpatients were infarction of 1eft brain, large area, multiple focus, and accepted aphasia, arrhythmia as well as hemipareses, This research could be used for clinician to set a discharge plan and a guideline to select patients in early rehabilitation programs.

Abstract Falls are the leading cause of accidental injury deaths among the elderly. Currently, the incidence and disease burden of falls among the elderly remain high. By understanding the influencing factors of falls among the elderly and formulating targeted preventive measures, the risk of falls can be effectively reduced. Studies have found that falls among the elderly are results of the interaction of multiple factors. When formulating fall prevention strategies, attention should be paid to fall risk assessment and stratification, fall prevention exercise support and health education, living environment improvement, and primary healthcare service enhancement. Reviewing publications pertaining to the epidemiological studies of falls from January 2004 to January 2024, this article summarizes the epidemiological characteristics, risk factors, prevention and control strategies of falls among the elderly, aiming to provide the reference for prevention and control.

Objective To investigate the alterations of interhemispheric resting-state functional connectivity in patients with chro-nic primary trigeminal neuralgia (CPTN).Methods Twenty patients with CPTN and 20 age-,gender-,and education-matched healthy subjects underwent a resting-state functional magnetic resonance imaging (rs-fMRI)scanning.The voxel-mirrored homo-topic connectivity(VMHC)approach and statistic analysis were used to investigate the interhemispheric coordination of the whole brain.Results Compared with healthy controls,decreased VMHC was found in patients with CPTN,including medial and lateral or-bitofrontal cortex,and premotor (P <0.05,GRF corrected).Conclusion Our results suggest that decreased VMHC in brain regions indicate the aberrant perceptual and affective processing of CPTN,and limited complex movements function.

Objective To explore the clinicopathological features and diagnosis of adenoid cystic carci noma of the breast (ACCB).Methods Clinical data of 3 cases of ACCB were collected and followed up to observe the clinical pathological features.Immunohistochemistry was used to determine the immune phenotype.Results All the 3 cases were female,aging from 55 to 72 years old (61 years old as the average).The tumors were found in subareolar region well-circumscribed.ACCB was characterized by the presence of a dual cell population of luminal and basaloid cells arranged in cribriform and tubular-trabecular patterns.On immunohistochemical staining,the myoepithelial cells expressed SMA,CK5/6,P63,CD117 and the glandular epithelium cells were mostly positive for CK18,EMA,CK7,while no expression of ER,PR,HER-2,CD10 was observed.Conclusions ACCB is a rare neoplasm with a triple-negative,basal-like phenotype,but exhibits an indolent clinical behavior.The diagnosis can be worked out by evaluation of clinical characterstics,histological and immunohistochemical features.