1.Influence of head nurse's leadership behavior on nurse's involvement and self-efficacy
Bin GAO ; Chunbo PU ; Xia ZHAO
Chinese Journal of Practical Nursing 2015;31(16):1232-1234
Objective To understand head nurse's leadership behavior and analyze the influence of it on nurse's involvement and self-efficacy.Methods General information questionnaire was taken,and the data of 280 nurses to head nurse's leadership behavior,involvement and self-efficacy were investigated.Results There were differences in nurse's involvement and self-efficacy between head nurse's transformation and transaction leadership behavior (F=4.39,2.37,2.94,2.17,P <0.05).The transformation leadership behavior dimensions were positive correlation with nurse's involvement and self-efficacy,P<0.05.Conclusion Head nurse should fully play a positive role of transformation leadership behavior,in order to promote involvement and improve self-efficacy.
2.Analysis of 5459 cleft lip and palate cases.
Bin XIONG ; Min ZHAO ; Ting CHENG ; Pu GAO
Chinese Journal of Plastic Surgery 2002;18(5):294-296
OBJECTIVETo analyse the constitution of 5459 cleft lip and palate cases and to review the development of surgical treatment to them.
METHODSThe data of the 5459 cleft lip and palate cases were collected and classified. The ratio of sex and disease pattern were calculated and analyzed statistically. Also, by means of classification of the disease pattern, the operation methods and the operation time, the change of the surgical methods and the first operation age were analyzed.
RESULTSIn the cleft lip and palate cases, the sex ratio is different. There were obvious differences in the first operative ages in different periods. The main repair methods for cleft lip and palate changed with time.
CONCLUSIONThe male is more than the female in the cleft lip and palate patients. The average first operation age has been decreased and the main repair methods have changed since 1980.
China ; epidemiology ; Cleft Lip ; epidemiology ; pathology ; surgery ; Cleft Palate ; epidemiology ; pathology ; surgery ; Female ; Humans ; Male ; Sex Factors ; Statistics as Topic
3.The usage of inferior turbinate mucosal flap for repairing cleft lip.
Pu GAO ; Min ZHAO ; Ke-ming QI ; Zhen-min ZHAO ; Bin XIONG
Chinese Journal of Plastic Surgery 2004;20(3):188-189
OBJECTIVETo evaluate a technique for decreasing the tension of the nasal floor during the procedures of repairing complete clef lip.
METHODSWith the designation of an inferior turbinate mucosal flap combined with an oral mucosal flap in the splitting side, the tension was effectively decreased and the nasal floor was closed easily. Eighteen patients was selected for the treatment with this technique since 2000. The follow-ups were 10 to 24 months.
RESULTSAll of the patients showed wound healing well with the significant improvement in the donor site.
CONCLUSIONThe above mentioned technique may effectively decrease the tension and be used to close the nasal floor safely. It could also reduce the incidence of the complications.
Cleft Lip ; surgery ; Female ; Follow-Up Studies ; Humans ; Infant ; Nasal Mucosa ; blood supply ; surgery ; Reproducibility of Results ; Surgical Flaps ; supply & distribution ; Surgical Procedures, Operative ; methods ; Treatment Outcome
4.Meconopsis quintuplinervia Regel Improves Cutibacterium acnes-Induced Inflammatory Responses in a Mouse Ear Edema Model and Suppresses Pro-Inflammatory Chemokine Production via the MAPK and NF-κB Pathways in RAW264.7Cells
Liying GAO ; Mi XIE ; Xiayu ZHANG ; Zhenhan QIU ; Zhen PU ; Shan HUANG ; Bin LI
Annals of Dermatology 2023;35(6):408-416
Background:
Acne vulgaris (AV) is a common adolescent skin condition which is mainly caused by Cutibacterium acnes overcolonization and subsequent inflammation.
Objective:
Our previous studies demonstrated that ethanol extracts of Meconopsis quintuplinervia Regel (EMQ) possess significant antimicrobial properties. However, their protective effects and potential mechanisms against AV remain unclear.
Methods:
In the present study, the EMQ treatment potential for AV was evaluated in a C.acnes-induced mouse ear edema model, and the EMQ anti-inflammatory mechanism was evaluated in lipopolysaccharide (LPS)-induced RAW264.7 macrophage cells.
Results:
The results showed that EMQ alleviated edema formation and inflammatory cell infiltration in an acne mouse model by suppressing inflammatory cytokines interleukin (IL)-6, IL-1β, and tumor necrosis factor α expression. Moreover, EMQ inhibited the phosphorylation of MAP kinases (MAPKs) such as p38, JNK, and ERK, the phosphorylation and degradation of IκB-α and the nuclear translocation of nuclear factor kappa B (NF-κB) p65 in LPS-induced RAW264.7 cells.
Conclusion
These findings suggest the potent anti-inflammatory activity of EMQ is possibly through the regulation of the MAPKs and NF-κB signaling pathways. Inhibition of C. acnes activity combined with a powerful anti-inflammatory effect of EMQ indicated its potential as a novel therapeutic option for AV.
5.Pseudotyping of murine leukemia virus particles with porcine reproductive and respiratory syndrome virus M protein-mediated E protein.
Ping-An XIA ; Zhan-Guo DANG ; Bin ZHOU ; Pu-Yanz CHEN ; Bao-An CUI ; Huang QIU ; Gao-Feng LU
Chinese Journal of Virology 2008;24(5):345-351
For constructing pcDNA-ORF5, pcDNA-ORF5-ORF6, pcDNA-ORF5/6, the ORF5 and ORF6 of porcine reproductive and respiratory syndrome virus (PRRSV) were amplified by RT-PCR, and transiently transfected into 293T cells by calciumphosphate co-precipitation. After 48 h, 293T cells were collected and surveyed by flow cytometry examination. The result indicated that the expression level of the E protein that mediated by the M protein was higher than that of the E protein expressed independently. Then pcDNA-ORF5, pcDNA-ORF5-ORF6, pcDNA-ORF5/6 were respectivly co-transfected into 293T cells with pHIT60 (include MuLV structural genes,namely gag and pol) and pHIT111 (retroviral genome, containing LacZ as a reporter). The supernatants were harvested 48 h post-transfection,and the analysis of the characteristic of the pseudotyping virions was performed by Western blot and infection test. The result indicated that the E proteins were expressed on the virions, and incorporated into the retroviral virions. Infection test were performed on Marc-145 and PAM, all the cells infected were Lac Z positive. These results indicated the pseudotype virions of MuLV-E and MuLV-E/M were infectious, and higher infectivity was achieved by MuLV-E/M.
Flow Cytometry
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Leukemia Virus, Murine
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genetics
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Plasmids
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Porcine respiratory and reproductive syndrome virus
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genetics
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Viral Envelope Proteins
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genetics
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physiology
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Viral Matrix Proteins
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genetics
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physiology
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Virion
;
genetics
6.Multi-central controlled study on three-part massage therapy for treatment of insomnia of deficiency of both the heart and spleen.
Yun-feng ZHOU ; Yu-long WEI ; Pu-lin ZHANG ; Shan GAO ; Guo-li NING ; Zhen-qiang ZHANG ; Bin HU ; Dan-yi WANG ; Mei-rong YAN ; Wen-jun LIU
Chinese Acupuncture & Moxibustion 2006;26(6):385-388
OBJECTIVETo make multi-central clinical evaluation for three-part massage therapy for treatment of insomnia of deficiency of both the heart and spleen.
METHODSOne hundred and sixty-six cases were randomly divided into a test group (n = 84) and a control group (n = 82). Multi-central, randomized and controlled methods were adopted. The test group were treated by the three-part massage therapy, i. e. acupoints at the head, abdomen and back were massaged, once each day; and the control group by oral administration of Guipi Pills [symbol: see text], 8 pills each time, thrice daily. The treatment was given for 15 consecutive days and then the therapeutic effects were observed.
RESULTSSixty-seven cases were cured, 11 markedly effective, 3 effective, and 3 ineffective in the test group, and the corresponding figures were 10, 21, 29 and 22 in the control group with a very significant difference between the two groups (P< 0.001). The test group was superior to the control group in improvement for Pittsburgh Sleep Quality Index (PSQI), Sleepless Anxiety Scale (SAS) and Sleepless Depression Scale (SDS) (P < 0.001).
CONCLUSIONThe three-part massage therapy has definite therapeutic effect on insomnia of deficiency of both the heart and spleen with safety.
Adult ; Female ; Humans ; Male ; Massage ; Middle Aged ; Sleep Initiation and Maintenance Disorders ; therapy
7.Comparison of chemical components of Lonicera fragrantissima and Lonicera japonica based on LC-MS
Ying JIN ; Le-Wen XIONG ; Gao-Bin PU ; Fang ZHANG ; Jia LI ; Long-Fei ZHANG ; Yong-Qing ZHANG
Chinese Traditional Patent Medicine 2024;46(3):850-859
AIM To compare the components difference between Lonicera fragrantissima Lindl.et Paxt.(LFL)and Lonicerae japonicae Flos(LJF),and to evaluate the medicinal value of LFL,so as to provide reference for the development and utilization of LFL and LJF.METHODS With 70%methanol as extraction solvent,the components were analyzed by UPLC-TOF-MS,and the contents of 20 components were determined by HPLC-QQQ-MS.The components difference was determined by multivariate statistical analysis.RESULTS A total of 52 components were identified in the buds of LFL and LJF.There were 4 different components in LJF,and the contents of 20 quantitative components were significantly different.The contents of isochlorogenic acid C,ferulic acid,luteolin and rutin in the buds of LFL were more than 2 times that of LJF,and the contents of marchanic acid and marchanin were 11.96 times and 37.23 times that of LJF respectively.Maganin,isochlorogenic acid A,maganic acid,rutin and dicomachanic acid are the key differentiating components of LFL and LJF.CONCLUSION The buds of LFL and LJF have similar species,but the content difference is obvious.The buds of LFL have important medicinal value,which need further development and utilization.
8.Epidemiological analysis of Mycoplasma pneumoniae acute infection in adults with community-acquired pneumonia.
Jiu-xin QU ; Li GU ; Jiang WU ; Xiao-li LI ; Jian-ping DONG ; Zeng-hui PU ; Yan GAO ; Ming HU ; Yong-xiang ZHANG ; Feng GAO ; Ying-mei LIU ; Shu-qiao YANG ; Xiu-hong JIN ; Xiu-hong MA ; Bin CAO ; Chen WANG ; null
Chinese Journal of Epidemiology 2012;33(5):545-546
Adolescent
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Adult
;
Aged
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Aged, 80 and over
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China
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epidemiology
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Community-Acquired Infections
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epidemiology
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microbiology
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Female
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Humans
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Male
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Middle Aged
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Pneumonia, Mycoplasma
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epidemiology
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Young Adult
9.Current status of hypoglycemic drug use among 3297 adult patients with type 2 diabetes in 15 urban communities of Beijing:Beiiing Community Diabetes Study-7
Bin LI ; Hanjing FU ; Shenyuan YUAN ; Liangxiang ZHU ; Jinkui YANG ; Gang WAN ; Sufang PAN ; Mei YU ; Xianglei PU ; Jiandong ZHANG ; Xueping DU ; Yuling LI ; Yu JI ; Xiaoning GU ; Yue LI ; Xueli CUI ; Wei BAI ; Yujie CHEN ; Ziming WANG ; Qingsheng ZHU ; Ying GAO ; Deyuan LIU ; Yipin WANG
Chinese Journal of General Practitioners 2011;10(11):796-800
Objective To investigate current status of use of oral hypoglycemic drugs and insulin among adult patients with type 2 diabetes mellitus (T2DM) in urban community of Beijing.Methods In total,3297 T2DM patients aged more than 20 years from 15 urban communities of Beijing were studied.Their body weight,height,fasting plasma glucose level and glycosylated hemoglobin Alc (HbAlc) were measured.A door-to-door questionnaire survey on use of oral hypoglycemic drugs and insulin was conducted for them.All the T2DM patients surveyed were divided into four groups based on their received intervention.Results ①Of 3279 T2DM patients,454 (13.8%) received lifestyle intervention,971 (29.5%) used only one oral hypoglycemic drug,1179 (35.7%) with combined oral hypoglycemic drugs,and 693(21.0%) with insulin.②There was significant difference in average HbAlc among the four groups of T2DM patients with lifestyle intervention,only one oral hypoglycemic drug,combined oral hypoglycemic drugs,and insulin,with HbAI c of (7.0 ± 1.9) %,(7.1 ± 1.5) %,(7.4 ± 1.5 ) %,and (7.5 ± 1.5 ) %for them,respectively ( F =15.1,P < 0.01 ).Proportions of the T2DM patients with HbAlc equal to or higher than 7.0% were 32.2%,39.4%,52.1% and 59.5% for the four groups,respectively ( x2 =117.7,P < 0.01 ).③In the T2DM patients with lifestyle intervention,32.2% (146/454) of them with HbA1 c equal to or higher than 7.0% were untreated with any oral hypoglycemic drug.In those with only one oral hypoglycemic drug,39.4% (383/971) of them with HbAlc equal to or higher than 7.0% were not treated with combined oral hypoglycemic drugs and/or insulin.In those with combined oral hypoglycemic drugs,52.1% (614/1079) of them with HbAlc equal to or higher than 7.0% were not received combined insulin treatment.④ Fasting plasma glucose level,treatment strategies,postprandial 2-h blood glucose level and length of the illness were independent risk factors for HbAlc level equal to or higher than 7.0%,with odds ratio (OR) of 1.757,1.256,1.175 and 1.031,respectively.⑤ In 2843 T2DM patients with oral hypoglycemie drugs and/or insulin treatment,1494 (52.6% ) received biguanides and 693 received (24.4% )insulin,respectively.Conclusions More than half of adult patients with T2DM do not meet the target of glycemic control of HbAlc less than 7.0% in urban communities of Beijing,due to not active use of oral hypoglycemic drugs,and not timely adoption of combined use of oral hypoglycemic drugs and insulin therapy.
10.Learning curve of complete mesocolic excision for colon cancer.
Peng GUO ; Ying-jiang YE ; Ke-wei JIANG ; Zhi-dong GAO ; Tie WANG ; Mu-jun YIN ; You-li WANG ; Qi-wei XIE ; Xiao-dong YANG ; Jun QU ; Bin LIANG ; Kai SHEN ; Fei XIE ; Hou-pu YANG ; Shan WANG
Chinese Journal of Gastrointestinal Surgery 2012;15(1):28-31
OBJECTIVETo evaluate the learning curve of complete mesocolic excision(CME) for colon cancer.
METHODSClinical data of 75 cases in whom CME was performed by a group of surgeons in the Department of Gastrointestinal Surgery, Peking University People's Hospital from November 2009 to June 2011 were reviewed. The patients were divided into three groups(groups A, B, C, 25 cases in each group) by operative chronologic sequence.
RESULTSThere were no significant differences in age, sex, preoperative staging, cancer location, operation history of abdomen, ASA among the three groups(P>0.05). The operative time in group A was (205.4 ± 53.2) min and decreased to (180.4 ± 29.7) min in group B and (169.8 ± 41.3) min in group C (P<0.05). The postoperative hospital stay decreased from (17.8 ± 10.9) d in group A to(12.9 ± 4.1) d in group B and(11.0 ± 3.5) d in group C(P<0.05). The postoperative complication rate decreased from 32%(8/25) in group A and 36%(9/25) to 8%(2/25) in group C. The specimen quality was superior in group C compared to group A (WEST grade C above were 20 and 11 respectively, P<0.05). There were no significant differences in intraoperative bleeding, time to first flatus, postoperative fasting time, number of retrieved lymph nodes among the three groups(P>0.05).
CONCLUSIONFrom the learning curve of CME, surgeons can learn CME skill after performing 25 cases.
Adult ; Aged ; Aged, 80 and over ; Colectomy ; education ; methods ; Colonic Neoplasms ; surgery ; Female ; Humans ; Learning Curve ; Male ; Mesocolon ; surgery ; Middle Aged ; Retrospective Studies ; Young Adult