Despite multimodel chemotherapy after successful surgical cytoreduction for ovarian cancer,disease recurrence continues to be problematic.Therefore,exploring new treatment strategy has already become urgent matter of the moment. Biological targeted therapies have been studied to overcome chemotherapy resistance.The most promising one at this time is bevacizumab.Results from phase Ⅱ and phase Ⅲ trials were excited.Deeper understanding of biologic pathway in ovarian cancer,and more biologic targets undergoing clinical trial will develop a new world for the treatment of ovarian cancer.

Objective To explore the application of ultrasonography (US) 5-grade system in the diagnosis of nasopharyngeal carcinoma(NPC).Methods A total of 150 patients suspected of having NPC underwent ukrasonography and MR imaging.All the lesions were scored according to the two different methods.Pathological results were made the golden criteria.The diagnosis accuracy of ultrasonography and MR imaging for NPC was evaluated using receiver-operating curve (ROC) analysis by Medcalc software.Results Both ultrasonography and MR imaging exhibited a good diagnostic performance for NPC with area under the curve (AUC) values of 0.958 and 0.987,respectively.The AUC difference of the two methods were statistically significant(Z =2.827,P =0.005).Conclusions Ultrasonography 5-grade system was an initial quantitative criterion for nasopharyngeal carcinoma diagnosis.The diagnosis accuracy was high although lower than MRI.But it could provide an overall economical and convenient complementary technique for clinical diagnosis.

Dorsal-ventral axis formation is one of the earliest and the most important steps of patterning formation during early embryogenesis.The molecular basis of dorsoventral axis formation reflects the fundamental issues of orchestrated cell proliferation and differentiation.Wildly speculated since the Renaissance,the effort of deciphering the mechanisms of dorsal-ventral axis formation has contributed significantly to our current understanding of disease pathogenesis.Here,we focused our discussion on the recent discovery of the convergence of dorsal and ventral signaling pathways during early embryogenesis and its implications in cancer biology and beyond.

Objective To observe and compare the recent objective response rate and adverse reaction of docetaxe and irinotecan combined with cisplatin in the treatment of advanced non-small cell lung cancer (NSCLC). Methods Sixty-five patients with advanced NSCLC were randomly divided into goup A consisted of 33 patients received docetaxe plus capecitabine and group B consisted of 32 patients received irinotecan plus capecitabine with a 21-day regimen. Two or more cycles of chemotherapy were completed in each group. Results Sixty-five patients were assessable for efficacy and toxicities. In group A, 2 patients achieved complete response, 13 patients partial response, overall response rate was 45.45 % and the median progression-free survival (PFS) was 10.1 months. In group B, 2 patients achieved complete response, 12 patients partial response, overall response rate was 43.75 %, and the median PFS was 10.2 months. The efficacy and PFS were not significantly different between the two groups(P ＞0.05). The most common adverse reactions were myelosuppression and gastrointestinal response in the two groups. The main adverse reactions is anemia in group A and diarrhoea in group B. Patients in group A experienced more anemia. On the contrary,the rate in group B was more increased. No chemotherapy-related death was observed. Conclusion The effects of docetaxe combined with cisplatin and irinotecan combined with cisplatin in the treatment of advanced NSCLC are comparable and equivalent, and the adverse reactions can be tolerated.

Objective To evaluate the value of routine head CT scan in diagnosing the fracture of orbital medial wall.Methods 40 cases doubted with the fracture of orbital medial wall were additionally scanned with orbital CT.Results Of 45 cases,35 cases were confirmed with fracture of orbital medial wall.The fracture signs on routine head CT included invagination of orbital medial wall,thick of medial rectus,increase in ethmoid sinus density and intra orbital gas.Conclusion Routine head CT scan can serve as diagnosing or screening the fracture of orbital medial wall.

OBJECTIVE To study characteristics of hospital infection,risk factors and bacterial resistance in our Intensive Care Unit(ICU) to draw up effective interfering measure and supply the scientific basis.METHODS The data of 1115 inpatients in our ICU in 2008 were analysed prospectively and retrospectively.RESULTS The hospital Infection rate was 12.10%,the case-time infection rate 12.47%,the lower respiratory tract infection rate 56.12%,the G-infection rate 57.30%,the G+ infection rate 25.84%,and the fungus infection rate was 16.85%,These pathogens were resistant to antibiotics in various degree.CONCLUSIONS The ICU infection rate is obvious higher than that in all clinical departments.The resistance to most of the antibiotics are increasing which need enhancing bacterial supervi.

The paper first sums up the types of clinical nursing ward rounds and points out that at present two types play a dominant role in China, viz. the problem-based nursing ward round and the nursing procedure-oriented nursing ward round. Then it expounds the goal of clinical nursing ward rounds, introduces the forms, participants, and schedules of nursing ward rounds, and analyzes the major problems that currently exist in this aspect. The paper argues that it is imperative for the hospital to reinforce the management of nursing ward rounds and ensure that they are well planned and prepared and highly standardized and focused so as to improve their quality.

A part of pathogenetic factors of hypertensionin twenty--seven patients with hypertensive NIDDM (group 1) were observed. The control groupsincluded non-hypertensive NIDDM (group 2, n=46 ), primary hypertension (group 3, n= 15) andhealthy persons (group 4, n= 15). The oral glu-cose tolerance test (OGTT), insulin releasing test(IRT ), atrial natriuretic peptide (ANP), an-giotensin I (ATI), aldosterone (ALD), wholeblood volume and urine protein were measured.The results showed that the plasma insulin andsodium levels and the whole blood volume weresignificantly higher in group 1 than those in con-trol group 2, the ANP level was rather lower than that in control group 4. Although the results werecorresponded with the theory that the circulatinghyperinsulinemia may lead to sodium retention andinhibited an adequate ANP stimulation by sodiumchallenge which turn to hypertension, nonhyper-tensive NIDDM patients (group 2) also have thesame findinge. So the retention of sodium and wa-ter can't be used to explain the mechanism of hy-pertension in NIDDM patients, the other patho-genetic factors especialy the factors related to thehyperinsulinemia such as PGE and PGI need to beinvestigated futher.

Objective To study the dynamic changes of DNA content of the fibroblasts in narrow pedicle subdermal vascular network flap (SVNP) during their surviving. Methods Eighteen pieces of surviving skin in pig back with size of 16 cm?8 cm and pedicle wideness of 4 cm were stained with acridine orange, and their DNA contents were measured with the adherent cell analysis and sorting cytometer 570. The tissue samples were taken at 3, 4 ,5 ,and 7 days after operation from different parts of the flap.Results The DNA content of fibroblast in the proximal part of the flap was slightly changed, those in the middle portion increased from 3rd to 5th day and became normal at 7th day, and in the distal portion progressively increased after operation. The results suggested that the transitional part of the flap and skin graft in the middle portion was most active in function and metabolism, and well survived, but the distal portion of the graft was poor in surviving and had a long repairing period. These indicated that local tissue hypoxia stimulated proliferation of fibroblasts and synthesis of the DNA in a short time, but as time wert by, the proliferative speed and DNA synthesis in the individual cell were heterogeneous, probably because of the degeneration or necrosis of some epidermal cells in the graft. Conclusion The wideness and length of the pedicle as well as its vascular anastomoses should be readjusted to promote the blood circulation of the distal skin graft tissues.

Enterostomy are a common surgical procedure in the treatment of rectal cancer, has more than 100000 each year in our country requires enterostomy patients, whereas patients with postoperative rehabilitation and nursing leave the family caregivers, the study found that with baseline levels of care for people, and increased mortality 63% of caregivers within five years, attaches great importance to the caregivers of patients with life can avoid the occurrence of another patient, at the same time also can improve the quality of family care, reduce the demand for medical and waste. Therefore, this article will from the permanent patients underwent colostomy care burden of family caregivers, health education needs, psychological burden to understand colostomy caregivers are faced with the problem of our country, explore the mental and physical health of the caregivers related factors, provide the basis for effective follow disease intervention.