Objective To observe the effect of simvastatin on serum levels of matrix metalloproteinase-9(MMP-9) and tissue inhibitors of matrix metalloproteinase-1 (TIMP-1) in patients with acute coronary syndromes (ACS).Methods 74 patients with coronary heart disease were studied.Among them,there were 34 patients with stable angina pectoris(SAP) and 40 patients with ACS.At the same time 25 cases of age matched healthy individuals were selected as a control.The serum level of MMP-gand TIMP-1 were compared among all groups.Results There was a significant difference in serum level of MMP-9and TIMP-1 among SAP group,ACS group and control group.The serum level of MMP-9 and TIMP-1 were different after treatment.Conclusion Plaque disruption may be related to the increased serum level of MMP-9 and the decreased serum level of TIMP-1 .Simvastatin can decrease serum level of MMP-9 and increase serum level of TIMP-1 in patients with ACS,and it may have a beneficial effect on clinical treating of patients with ACS.

MicroRNA (miRNA)is a kind of endogenous non-coding protein single-chain small RNA consisted of 18~25 nucleotides.In recent years,researches found that miRNAs played important modulating role in occurrence and development of heart diseases.This article made an overview for that.

Objective To investigate the effect of melatonin on serum malondialdehyde (MDA), NF-κB, tumor necrosis factor-α(TNF-α) andβ2-microglobulin (β2-MG) levels in secondary brain damage following intracerebral hemorrhage patients.Methods 90 patients secondary brain damage following intracerebral hemorrhage were divided into experimental group and control group, 45 cases in each group.The control group were given conventional treatment after surgical removal of hematoma, and the experimental group, on the basis of control group, were given melatonin capsule (6 mg melatonin) , orally, once a day, for 2 weeks treatment.The levels of MDA, NF-κB, TNF-αand β2-MG in patients’ serum were detected.Results The MDA, NF-κB, TNF-αand β2-MG levels after treatment significantly decreased compared with before treatment in two groups (all P<0.05), and the above indexes in experimental group significantly decreased compared with control group ( P <0.05 ).Conclusion Melatonin can significantly reduce the levels of MDA, NF-κB, TNF-αand β2-MG levels in brain injury patients with cerebral hemorrhage, and repair brain damage, which has a guiding significance for clinical use.

Objective To observe the effect of interferon combined with kenacort in the treatment of scars. Methods According to random number table,287 patients with scars were randomly divided into treatment group and control group.The treatment group(145 cases) was treated with injection of the mixture of interferon and kenacort. The control group(142 cases) was applied with contratubex.The effect and adverse reaction of the two groups were compared.Results The total effective rate of the treatment group was 95.86%,which was higher than 64.08% of the control group,the difference was statistically significant(χ2 =45.52,P<0.01).The incidence rate of adverse reaction of the two groups had no statistically significant difference(χ2 =1.25,P>0.05).Conclusion These find-ings may shed some light on the clinical application of combined injection therapy on scar treatment,given that the closed dynamic method of injecting interferon combined with kenacort significantly improved scar healing.

SLE-like syndrome in (C57BL/6 x BALB/c) F1 mice can be induced by intravenous injection of lymphocytes from BALB/c parental mice. In these SLE-like mice levels of DNA antibody and anti—histone increased and there were immuno-complex mediated proteinuria, glomerulonephritis. 28 days later artesunate was given intraperitoneally to daily these mice. The results revealed that artesunate could significantly suppress the progression of disease activity,

AIM:To establish a fingerprint method of analyzing Xuefu Zhuyu Capsule(Semen Persicae,Radix Angelicae sinensis,Fruclus Aurantii,Rhizoma Chuanxiong,etc.) by HPLC. METHODS: A HPLC in combination with PDA detector was applied with a HiQ C_(18)(4.6 mm?250 mm,5 ?m) column by gradient elution using methanol-1.0% acetic acid solution as the mobile phase.The flow rate was 0.5 mL/min and the detection wavelength was at 260 nm. RESULTS: Thitrty-six common peaks were obtained in the fingerprint of Xuefu Zhuyu Capsule with good separation,six of them were identified as adenosine,paeoniflorin,naringin,hesperidin,neohesperidin and ligustilide by comparing chromatogram with control compounds. CONCLUSION: The HPLC method with good precision and reproducibility can be used for the quality control of Xuefu Zhuyu Capsule.

Galectin-3, encoded by LGALS3 (14q21-22) and secreted by normal cells and tumor cells, is a member of Galectin family and can be detected both in serum and plasma. Galectin-3 is considered to be an important indicator of the assessment of the patients with malignant tumor and heart failure. The high expression of Galectin-3 may be correlated with poor response to chemotherapy, high recurrence rate, low survival rate and short survival period, which can be a prognostic marker in some solid tumors, including thyroid cancer, gastric cancer, colon cancer, breast cancer. Foreign studies have found that the high expression of Galectin-3 in many kinds of malignant tumors is closely related to the prognosis of the disease. In this paper, the correlation between Galectin-3 and blood tumors is reviewed to study the expression of Galectin-3 in the blood tumors and its relationship with the occurrence, development and prognosis of the tumor, and to explore the theoretical basis for the targeted therapy of Galectin-3.

Objective To observe the clinical efficacy of Yang Xin Huo Xue(nourishing the heart and activating blood flow) needling method plus Western medication in treating chronic heart failure due to coronary heart disease (CHD).Method Eighty patients with CHD-induced chronic heart failure were randomized into a treatment group and a control group, to respectively receiveYang Xin Huo Xueneedling method plus Western medicationor Western medication alone for intervention. The heart function was estimated and brain natriuretic peptide (BNP) was detected before and after the intervention in both groups, and the change of heart function was observed.Result Yang Xin Huo Xueneedling method plus Western medication achieved a satisfactory therapeutic efficacy in treating chronic heart failure, and its total effective rate was significantly different from the rate in the control group (P<0.05); compared with the control group, the BNP value declined more significantly in the treatment group, and the difference was statistically significant (P<0.05).Conclusion Yang Xin Huo Xueneedling method plus Western medication can produce a satisfactory efficacy in treating CHD-induced chronicheart failure.

The mental health situation in Chinese populations was analyzed, followed by an elaboration on the feasibility, methods and measures to carry out free-reading therapy in provincial mental disease hospital libraries.