Objectives To investigate the DRD 2 genetic susceptibility to essential tremor(ET) in Chinese.Methods Polymerase chain reaction-restricted fragment length polymorphism(PCR-RFLP) was used to determine the DRD 2 Taq ⅠA genotypes of 80 unrelated ET patients and 100 healthy controls.Results No significant differences in Taq ⅠA genotype and distributions of allele frequencies of Taq ⅠA loci at the DRD 2 gene were observed between ET and controls.Conclusions Taq ⅠA loci polymorphism at DRD 2 gene may be not associated to genetic susceptibility to ET,but the Taq ⅠA polymorphism at DRD gene could contribute the disorder of central dopaminergic neural system in ET.