Ganglionneuroma is slow-growing benign neoplasm that orignates from the sympathetic nervous system. A case of dumb-bell shaped Ganglionneuroma at first and second cervical areas is presented on this paper with chief complaint of neck pain and quadriparesis. The tumor was totally removed under operating microscope and the diagnosis was pathohistologically confirmed. The postoperative result was good and relative literatures were reviewed.
Diagnosis ; Ganglioneuroma* ; Neck Pain ; Quadriplegia ; Sympathetic Nervous System

The authors report a rare case of retroperitoneal ganglioneuroma discovered incidentally in a 47-year-old male during abdominal computed tomogaphy(CT) evaluation. The clinical features and findings of the complementary examinations, which included radiological assessment, abdomen CT and lumbar spine magnetic resonance image with contrast enhancement are presented, as well as the pathology findings. The tumor, 10x10x6cm in size, was well encapsulated and total removal was made. Histopathological diagnosis of retroperitoneal ganglioneuroma was confirmed.
Abdomen ; Diagnosis ; Ganglioneuroma* ; Humans ; Male ; Middle Aged ; Pathology ; Spine

PURPOSE: Ganglioneuroma is a relatively uncommon benign tumor and han no pathognomonic radiological findings;diagnosis is therefore difficult. In order to better diagnose this tumor we analysed its CT findings andpathologic correlation. MATERIALS AND METHODS: Seventeen tumors in 16 patients(M:F=9:7) diagnosed asganglioneuroma between 1992 and 1996 were retrospectively analysed with regard to location, size, contour, longaxis of the mass, enhancement pattern, calcification, necrosis and capsulation, all as seen on CT, and comparedwith histo- pathologic findings. RESULTS: Tumors were 1.5 to 10(mean, 5.6)cm in size, and their location wasmediastinal(n=12), cervical(n=2), retroperitoneal (n=2) or adrenal(n=1). Fifteen had an oval or round contour andtwo were dumb-bell-shaped. The long axis of the lesion was craniocaudal in 14 cases and non-specific in three.Thirteen lesions showed heterogeneous enhancement, and four homogeneous. Capsule-like enhancement was noted on CTscans in eight cases;there was no definite correlation between enhancement pattern and pathologic findings.Calcification was seen in six cases and an inner low-density lesion in two. CONCLUSION: Ganglioneuroma is abenign neurogenic tumor, occurring most frequently at the the posterior mediastinum. General CT findings of thistumor are a well-defined oval shape with a variable enhancement pattern, but several cases showed focalcalcification or inner low density. For accurate diagnosis of ganglioneuroma both common and uncommon findingsmust therefore be considered.
Axis, Cervical Vertebra ; Diagnosis ; Ganglioneuroma* ; Mediastinum ; Necrosis ; Retrospective Studies

Ganglioneuroma (GN) is a rare benign tumor of neural crest origin usually found in the abdomen, but may occasionally present at uncommon sites including the cervical, lumbar, or sacral spine. However, GNs of thoracic spine are extremely rare. In this report, we describe a 12-year-old girl with giant GN in the thoracic spine, who underwent successful resection (T1–4 level) of the tumor. Histopathological examination confirmed the diagnosis. GN should be considered in the differential diagnosis of any paraspinal mass. A high index of suspicion and correlation of clinico-radiological findings is necessary in differentiating a large benign tumor from a malignant growth. Complete surgical excision is the treatment of choice; however tumor size and location need to be considered for the surgical approach (one-step or multiple surgeries). Close follow-up after surgery is mandatory.
Abdomen ; Child ; Diagnosis ; Diagnosis, Differential ; Female ; Follow-Up Studies ; Ganglioneuroma* ; Humans ; Neural Crest ; Spine*

PURPOSE: Benign adrenal tumors other than hyper-functioning tumor and non-functioning cortical adenoma are extremely rare. The purpose of this study is to review the clinical features of these rare benign adrenal tumors and to analyze their prevalence and the proper surgical approach for them. METHODS: Among patients who underwent adrenalectomy in Samsung Medical Center, between 1997 and 2013, patients with benign adrenal tumor except non-functioning cortical adenoma, malignancy, and hyper-functioning tumor such as pheochromocytoma, aldosteronoma, and cortisol producing tumor were included. Clinical details, radiologic findings and pathologic findings as well as data associated with the surgical procedure were analyzed retrospectively. RESULTS: The percentage of these tumors among 703 surgically removed adrenal tumors was 10.7% (75 cases). They included 30 adrenal cysts, 18 ganglioneuromas, 11 myelolipomas, seven schwannomas, and the other six were rare adrenal tumors. Approximately 40% of the patients were operated under a diagnosis different from original tumors. Operation time and hospital stay of patients who underwent laparoscopic adrenalectomy were shorter than those of patients who underwent open adrenalectomy. CONCLUSION: These benign adrenal tumors are very rare and difficult to diagnose preoperatively. For the surgical treatment of these tumors, laparoscopic adrenalectomy is more preferable to conventional open adrenalectomy.
Adenoma ; Adrenalectomy ; Diagnosis ; Ganglioneuroma ; Humans ; Hydrocortisone ; Length of Stay ; Myelolipoma ; Neurilemmoma ; Pheochromocytoma ; Prevalence ; Retrospective Studies

We report an extremely rare case with bilateral and symmetric dumbbell ganglioneuromas of the cervical spine in an elderly patient. A 72-year-old man came by ambulance to our hospital due to progressive incomplete paraplegia. Magnetic resonance imaging demonstrated bilateral symmetric dumbbell tumors at the C1/2 level. We performed total resection of the intracanalar tumor, aiming at complete decompression of the spinal cord, and partial and subtotal resection of foraminal outside portions. Histopathological examination of the surgical specimen indicated the tumor cells to be spindle cells with the presence of ganglion cells and no cellular pleomorphism, suggesting a diagnosis of ganglioneuroma. Although the surgery was not curative, the postoperative course was uneventful and provided a satisfactory outcome. This is the fourth known case of cervical ganglioneuromas of the bilateral symmetric dumbbell type.
Aged ; Ambulances ; Decompression ; Diagnosis ; Ganglion Cysts ; Ganglioneuroma* ; Humans ; Magnetic Resonance Imaging ; Paraplegia ; Paresis* ; Spinal Cord ; Spine

Ganglioneuroma is a well-differentiated, benign tumor of the sympathetic nervous system. These tumors belong to a family of neoplasm that exhibit a wide range of differentiation, with neuroblastoma at one end and ganglioneuroma at the other. Because it share morphologic features with other both benign and malignant neural tumors, accurate preoperative diagnosis is often difficult. Nonetheless, it is critical for proper management. Fine needle aspiration cytology(FNAC) in the diagnosis of the ganglioneuroma has been a little documented. We describe a case of mediastinal ganglioneuroma in a 33-month-old girl. The diagnosis was suggested on FNAC and was confirmed by histopathologic examination later.
Biopsy, Fine-Needle* ; Child, Preschool ; Diagnosis ; Female ; Ganglioneuroma* ; Humans ; Mediastinum ; Neuroblastoma ; Sympathetic Nervous System

Ganglioneuroma is a rare benign tumor and it is thought to arise from the ganglia of the sympathetic or parasympathetic nervous system. This tumor most commonly presents in patients younger than 20 years of age and is seen in the thorax, including posterior mediastinum and in the abdomen, including retroperitoneum. But, ganglioneuroma in the face is exceptional. Ganglioneuroma is slow growing, non-invasive lesion that is often detectable incidentally as painless mass or which effects on neighboring structures. A 14-year-old female patient with neuroblastoma was undergone surgical excision due to buccal cheekmass, and the diagnosis of mass was ganglioneuroma. Thus, we report the rare case of ganglioneuroma with literature review.]]>
Abdomen ; Adolescent ; Cheek ; Diagnosis ; Female ; Ganglia ; Ganglioneuroma ; Humans ; Mediastinum ; Neuroblastoma ; Parasympathetic Nervous System ; Thorax

We report two cases of supratentorial gangliocytomas mimicking an extra-axial tumor. MR imaging indicated that the tumors were extra-axial, and meningiomas were thus initially diagnosed. Relative to gray matter, the tumors were hypointense on T1-weighted images and hyperintense on T2-weighted images. On contrast-enhanced T1-weighted images, homogeneous enhancement was observed, while CT scanning revealed calcification in one of the two cases.
Adult ; Brain Neoplasms/*diagnosis/pathology ; Case Report ; Female ; Ganglioneuroma/*diagnosis/pathology ; Human ; *Magnetic Resonance Imaging ; Middle Age

Adult ; Cerebellar Neoplasms ; diagnosis ; pathology ; Female ; Ganglioneuroma ; diagnosis ; pathology ; Humans ; Magnetic Resonance Imaging ; methods ; Male ; Middle Aged