1.Acute myeloid leukemia with NPM-MLF1 fusion gene: report of one case and review of literature
Gangji ZHANG ; Wei LI ; Shaowei QIU ; Shuning WEI ; Kaiqi LIU ; Yuntao LIU ; Benfa GONG ; Runxia GU ; Xiaoyuan GONG ; Bingcheng LIU ; Chunlin ZHOU ; Hui WEI ; Ying WANG ; Dong LIN ; Yingchang MI ; Jianxiang WANG
Journal of Leukemia & Lymphoma 2017;26(5):283-286
Objective To investigate the characteristics of NPM-MLF1 fusion gene in acute myeloid leukemia (AML). Methods The data of one AML patient with NPM-MLF1 fusion gene was analyzed,and literatures were reviewed. Results A female patient was diagnosed as AML M6. In the course of the disease, 2 hematologic relapsed, and 2 recurrences were associated with NPM-MLF1 fusion gene positive. After inductive treatment, hematologic complete remission was achieved, and NPM-MLF1 fusion genes were all negative. Survival time surpassed 6 years when the chemotherapy was performed alone. Conclusion The incidence of NPM-MLF1 fusion gene in AML is low. It is necessary to collect more clinical data to judge whether an independent disease type or not.
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