Molecular simulation was used to study the interaction between template molecule and functional monomer to shorten the optimization time for the functional monomer and the ratio of functional monomer and template molecule.Kaempferol molecularly imprinted polymerization (MIP) monolithic column was therefore synthesized by reversible addition-fragmentation chain-transfer (RAFT) polymerization with dibenzyltrithiocarbonate (DBTTC) and ethyleneglycoldim ethacrylate (EDMA) as RAFT and cross-linking agent, respectively, whereas methacrylic acid (MAA) was the optimal functional monomer with the molar ratio of kaempferol/MAA of 1∶4 from molecular simulation results.The results indicate that molecular simulation is useful to simplify the experimental procedure, and DBTTC as RAFT agent can provide more adjustable and better MIP monolithic column.

Objective To investigate the clinical results of selective decompression and short-segment fusion with fixation for symptomatic degenerative lumbar stenosis combined with lumbar scoliosis.Methods All of 30 patients from Jul.2008 to Oct.2013 were recruited for this retrospective study.There were 11 males and 19 females,whose mean age was 60.3±12.7 years.The preoperative X-ray of the total spine showed the mean Cobb's angle was 24.3°±8.8°.And the mean lumbar lordosis angle was 30.5°±15.5°.Pain and function were assessed by Visual Analogue Scale (VAS) and Oswestry dsability index (ODI).The responsible segments were determined from physical examination and radiological findings.Selective decompression and short-segment fixation and fusion were performed.The radiographic parameters,ODI,VAS of pre-operation and post-operation were recorded and compared.Results All the patients were followed up for 21-73 months with mean 46.0±10.9 months.The complication incidence was 33.3％.The ODI and VAS assessment was significantly improved during the follow-up,as well as the sagittal and coronal radiographic parameters (LL,SS,PT,SVA,Cobb's angle,C7PL-CSVL).The improvement of VAS and ODI of lumbar spine was significant correlated with sagittal parameters (LL,PT),whilst not correlated with coronal parameters.Conclusion The surgical strategy of selective decompression and short-segment fusion with fixation is effective for the patients with symptomatic degenerative lumbar stenosis combined with lumbar scoliosis.