OBJECTIVE:To compare the efficacy and safety of levofloxacin and moxifloxacin in the treatment of patients with drug-resistant tuberculosis. METHODS:148 patients with drug-resistant tuberculosis were divided into observation group(74 cases) and control group(74 cases). All patients were treated with 300 mg Aminosalicylic acid isoniazid tablet+250 mg Ethambutol hydro-chloride tablet+200 mg Pyrazinamide tablet+200 mg Protionamide tablet,3 times a day,treatment for 3 months;based on it,obser-vation group was orally given 0.4 g Moxifloxacin hydrochloride tablet,once a day;control group was orally given 0.5 g Levofloxa-cin hydrochloride tablet,once a day. They were treated for 12 months. The total efficacy,sputum negative convevsion rate after 1, 4,8 and 12 months,X-ray cavities lesion improvement and incidence of ADR in 2 groups were observed. RESULTS:The total effi-cacy,sputum negative conversion rate after 1,4,8 and 12 months,and cavity closure and reduced proportion in observation group were significantly higher than control group,the empty change and increase proportion,incidence of ADR were significantly lower control group,the differences were statistically significant (P<0.05). CONCLUSIONS:Based on conventional treatment, moxifloxacin shows better efficacy and safety than levofloxacin in the treatment of patients with drug-resistant tuberculosis.

The rapid progress in surgery in China has been closely related to government investment in public health care, construction of medical talents team, and basic and clinical research. The achievements of bench studies promote the development of clinical surgery. Translational medicine (bench-bedside-bench) has gained much attention in the medical community. The driving force promoting long-term development of surgery in China includes collaboration of basic scientists and surgeons, cultivation of surgeons with aptitude in scientific research, initiation of clinical research and popularization of multidisciplinary team.
Biomedical Research ; China ; General Surgery ; Humans

Combined Modality Therapy ; Humans ; Stomach Neoplasms ; therapy

Objective To summarize and discuss the laboratory characteristics of children with incomplete Kawasaki disease(IKD)in recent 10 years and provide some evidence for early diagnosis. Methods A retrospective review was performed on 67 children with IKD and 67 children with respiratory tract infection(bacterial infection)from 2005 to 2015 in the First Hospital of China Medical University. Results The age of chil-dren with IKD varied from 2 months to 11.3 years,with the average age of 31 months. Totally 86.5%of the children were less than 5 years old. The male to female ratio was 2:1. The incidence of the disease in spring and summer was 72%. The incidences of the increasing of white blood cell ,C-reactive protein,alanine aminotransferase,aspartate aminotransferase,glutamyl transpeptidase,and platelet and the decreasing of hemoglobin and serum albumin were 82%,94%,27%,24%,45%,72%,61%,and 94%,respectively. Conclusion The levels of the hemoglobin(<109 g/L), serum albumin(<34 g/L),platelet(>393×109/L),C-reactive protein(>74 mg/L),alanine aminotransferase(>51 U/L),and glutamyl transpepti-dase(>43 U/L)may have a certain reference value for the early diagnosis of IKD.

Combined Modality Therapy ; Humans ; Stomach Neoplasms ; therapy

Gastric cancer remains one of the most common causes of cancer-related death in China. Radical operation is the only potentially curative therapy for advanced gastric cancer (AGC). D2 radical gastrectomy has been widely accepted as a standard surgical procedure for patients with AGC in China. Several clinical trials have revealed that more extended resection than D2 surgery has no impact on survival. In order to improve the prognosis of AGC patients, it is necessary to carry out the preoperative TNM staging for selecting a reasonable therapeutical modality before surgery. Multimodality treatment involving perioperative chemotherapy, radiotherapy or molecular targeting agents in addition to surgery have been thought to be promising treatment strategy. In this article, we present an update on the current literature regarding the trends of surgical multimodal treatment for the patients with AGC.
Combined Modality Therapy ; trends ; Humans ; Stomach Neoplasms ; surgery

As a heparin-binding growth factor, midkine plays an important role in the nervous system, cancer, and inflammatory response.Midkine is involved in the occurrence and development of many autoimmune diseases.This article reviews the role of midkine in renal ischemia reperfusion injury, crescentic glomerulonephritis, lupus nephritis, diabetic nephropathy, and Henoch-Schonlein Purpura nephritis.

Carcinoma, Neuroendocrine ; pathology ; Carcinoma, Squamous Cell ; pathology ; Humans ; Neoplasm Staging ; Thymoma ; classification ; pathology ; Thymus Neoplasms ; classification ; pathology ; World Health Organization

The incidence of gastric cancer has declined worldwide in the past decades. However, due to the large number of population in mainland of China, the absolute number of newly-diagnosed patients in this developing country is still very high. Most of the major clinical centers have established multi-disciplinary team, but the strategy in treating this life-threatening disease still needs to be optimized, including the precise preoperative staging by various techniques, perioperative chemotherapy for locally advanced diseases, role of minimally invasive surgical approaches in treating patients with different stages, translational research to fill the gap between clinical trials and basic research, as well as the individualized treatment for gastric cancer. We believe that the biological behaviors and molecular events of gastric cancer in eastern countries are different from that of Western countries, so the clinical evidences derived from Eastern countries need to be strengthened to enrich the unmet demands in the clinical practice in China.
China ; Combined Modality Therapy ; Humans ; Stomach Neoplasms ; drug therapy ; surgery ; therapy

Objective Investigate the toxicity of polylactic acid,polyglacolic acid and chitosan on peripheral nerves,so as to detect the polymers with good biocompatibility to fabricate the scaffold of tissue engineered nerve Method Fifteen Sprague Dawley rats were divided into 3 groups randomly;polylactic acid,polyglacolic acid and chitosan were implanted into the sciatic nerves respectively.7 weeks later,the nerves with polymers were harvested and inspected by macroscopy and light microscope. Results There was mild hypertrophy of fibrous connective tissue within the nerves in each group.However,the nerve fibers were intact The polymers were surrounded by a pseudocapsule,and lymphocytes and macrophages infiltrated.The pseudocapsule coating chitosan was the thickest. Conclusion polylactic acid, polyglacolic acid and chitosan have no toxic effect on peripheral nerves.