Objective To evaluate the prognosis of tongue carcinoma surgery with preservation of the integrity of mandible and dentition .Methods Sixty four cases of tongue carcinoma surgery from January 2009 to January 2011 were randomly collected (sev‐en missed ,57 enrolled) .Through retrospective case‐control study on retention of mandibular dentition and mandible rectangle radi‐cal operation of tongue carcinoma radical operation of tongue cancer resection were analyzed the clinical data including the survival rate ,reoccurrence rate and post‐operation life quality .The questionnaire was conducted by fourth edition of UW‐QOL .Results There were no significant difference in survival rates of the two groups of patients between retaining the mandible and dentition and resection of mandible rectangle (P>0 .05) .Two different types of surgical procedures for treatment of jaw had no correlation with the reoccurrence rate (P>0 .05) .The quality of life in retaining the mandible and dentition was significantly higher than the rectan‐gular groups (P<0 .05) .Conclusion Under a strict choice of surgical indications ,preserving radical operation of tongue carcinoma of the mandible and dentition could achieve good results of surgical treatment ,and can significantly improve patients′quality of life after operation .

[ABSTRACT]AIM:ToobservetheeffectofthesignalingpathwayofproteinkinaseC(PKC)-nuclearfactor-ery-throid 2-related factor 2 (Nrf2) on the expression of heme oxygenase-1 (HO-1) induced by cigarette smoke extract (CSE) in the rat airway epithelial cells .METHODS:After exposed to CSE , the airway epithelial cells of male SD rats were di-vided into control group , CSE3 group, RO318220 group, Nrf2 siRNA group and RO318220+Nrf2 siRNA group.The pro-tein levels of HO-1, Nrf2 and PKC were semi-quantified by Western blotting .The protein expression of HO-1 was assessed by immunocytochemistry .The mRNA expression of HO-1 was detected by reverse transcription-polymerase chain reaction ( RT-PCR) .Nrf2 protein location was observed by immunofluorescence staining .HO-1 activity was also determined .RE-SULTS:After exposure to CSE for 3 h, the Nrf2 protein was mainly located in the nucleus , and the expression level of Nrf2 protein in the nucleus was stronger than that in the control cells .CSE also significantly enhanced the levels of p-PKC protein, and HO-1 mRNA, protein and activity .Pretreatment with RO318220 significantly decreased the levels of PKC pro-tein, Nrf2 protein, and HO-1 mRNA, protein and activity.Meanwhile, Nrf2 protein significantly decreased , and the activ-ity, mRNA and protein levels of HO-1 were also significantly attenuated by pretreatment with siRNA to knock down Nrf2. Pretreatment with RO318220 and Nrf2 siRNA significantly decreased the PKC protein , Nrf2 protein, and HO-1 mRNA, protein and activity .CONCLUSION:CSE up-regulates the HO-1 expression through PKC-induced nuclear translocation of Nrf2 in the rat airway epithelial cells .

BACKGROUND:Although core decompression can contribute to the reconstruction of necrotic bone, its single use appears to have some deficiencies and cannot completely realize the reconstruction of the femoral head.
OBJECTIVE:To explore the effect of arthroscopic core decompression with autologous bone marrow induction material combined with titanium rod in the repair of stage II femoral head necrosis
METHODS:A retrospective analysis was performed on clinical data of 79 cases of stage II femoral head necrosis admitted at the South Branch of Tongchuan People’s Hospital from February 2011 to February 2013. According to the therapeutic methods, these cases were divided into control group (40 cases) and observation group (39 cases), and were given conventional core decompression and arthroscopic core decompression with autologous bone marrow induction material combined with titanium rod. Patients were fol owed up for 24 months, and the range of hip flexion and Harris scores on hip function and adverse events were observed and compared between two groups.
RESULTS AND CONCLUSION:Al the 79 patients successful y completed the 24-month fol ow-up. By the last fol ow-up, the range of hip flexion and Harris score were significantly higher in the observation group than the control group (P<0.05). There was no failure case due to surgical material rejection. To sum up, arthroscopic core decompression with autologous bone marrow induction material combined with titanium rod is safe and effective for repair of stage II femoral head necrosis.

Objective To investigate the effect of nutrition support therapy on quality of life in patients with advanced tumors.Methods 70 patients with advanced tumors were randomly divided into the observation group and the control group,each group had 35 cases.The control group was given conservative treatment,together with the ordinary liquid,semi-liquid or diet.The observation group was given nutrition support therapy on the basis of conservative therapy.The nutrition and immune index and symptom score,quality of life were compared between the two groups.Results The nutrition,immune indexes (Alb,BMI and NK) and symptom score (malaise,anorexia,insomnia,pain) of the observation group were significantly improved(t =7.92,6.98,5.56,7.41,6.47,5.61,4.52,all P ＜ 0.05),which were significantly better than those of the control group(t =4.42,4.10,4.03,6.42,5.60,4.83,4.23,all P ＜0.05).The physical function,role function,emotional function,cognitive function score and total score of the observation group were significantly higher than those of the control group,the differences were statistically significant (t =8.12,6.08,5.12,4.78,4.32,all P ＜ 0.05).Conclusion Nutrition support therapy can improve the nutritional status of cancer patients in advanced stage,relieve symptoms,improve immune function and quality of life,which is worthy of clinical application.

Renal fibrosis is the final common pathway for all kinds of chronic kidney diseases to end-stage renal diseases. Angiotensin Ⅱ plays an important role in the process of renal fibrosis. How to block angiotensin Ⅱ has been a focus of nephrology. This article reviewed the progress in traditional Chinese medicine against renal fibrosis with angiotensin Ⅱ as research target.

Objective To observe the application effect of mental nursing on perioperative nursing of patients. Methods 66 patients with cutaneous carcinoma were randomly divided into the conventional nurs-ing group and the psychological intervention group. The conventional nursing group received perioperative mu-fine nursing,the psychological intervention group was given mental intervention before,during and after operation based on routine nursing. The anxiety value was measured before and 30 minutes after the operation, pain de-gree was assessed 30 minutes after the operation,the results underwent t test and X2 teat. Results Compared to the conventional nursing group, the anxiety value before the operation and 30 minutes pestoperation as well as pain degree 30 minutes pestoperation of the psychological intervention group were significantly decreased. Conclusions Mental nursing of patients with cutaneous carcinoma can efficiently eliminate or re-duco patients' psychologic obstacle and significantly reduce patients' painful feeling.

BACKGROUND: To summarize the feature and clinical application of various injectable bone substitutes.DATA SOURCES: The computer-based research was done in Pubmed database for articles concerning various injectable bone substitutes published from January 1995 to May 2009 with the key words of "injectable bone substitute, bone injury" in titles and abstracts. Literatures of the same fields published in recent years or in authorized journals were selected.DATA SELECTION: Latest literatures addressing feature and clinical application of various injectable bone substitutes were selected; old and repetitive studies were excluded. Finally, 21 articles were included.MAIN OUTCOME MEASURES: Feature and clinical application of various injectable bone substitutes were measured.RESULTS: Present various injectable bone substitutes contained complex hydroxyapatite bone substitutes, complex calcium sulfate bone substitutes, and complex calcium phosphate bone substitutes. Addition of bone morphogenetic protein-2 etc. in injectable bone substitute could significantly elevate bone union speed, promote osteoblastic proliferation, and overcome disadvantage of physical bone substitute to some degrees. Addition of platelet-rich plasma could promote repair effect of injectable bone substitute on bone defects, and promote differentiation of bone marrow stromal stem cells and proliferation of osteoblasts. Addition of cells could make up the insufficiency of physical materials to great degrees.CONCLUSION: The compound injectable bone substitute has a bright perspective of clinical application. Injectable bone substitutes combined with cells (especially stem cells) will be a new direction for biomaterial development in the future.

Headache is a common clinical symptom.Some headache disorders belong to secondary category.Many intracranial disorders,such as head trauma,cerebral vascular diseases,intracranial tumors and inflammation,can lead to headache due to mass effect,inflammation reaction,stimulation of vasoactive substances and decreased intracranial pressure.Furthermore,many drugs and other substances,disorders of eyes,nose,ear,mouth,neck and other systemic disorders can also cause headache.Many headache disorders can be determined by detailed case history and physical examination.Blood test,lumber puncture,CT,MRI and other imaging examinations are necessary methods for finding the causes and the treatment of diseases.

Objeetive To observe the effect of the fire and leopard-spot needling therapy in treating ankle sprain.Methods We randomly selected 59 ankle sprain cascs and divided them into 2 groups,with one contained 30 cases treated hy fire and leopard-spot needling therapy as the treatment group,and another contained 29 cases treated by computerized multa-function therapy apparatus as the control group.After 7 days'treatment,we observed the effects of each group.Results The results snowed that the effect of the treatment group was much better than the control group.Conclusion With the features of collateral vessel pricking and warming and activating meridians,fire and leopard-spot needling therapy can remove swelling and relieve pain rapidly.

Aim To examine subcellular localization of serotonin 5-HT2A receptor (5-HT2AR) and glutamate NMDA receptor in dorsal hippocampal CA1 area ( dCA1 ) and further explore the effect of systemic acti-vation of 5-HT2A R on hippocampal neuronal firing rate. Methods The distribution of 5-HT2A R and NMDA re-ceptor in the dCA1 region was detected with immune e-lectron microscopy after embedding. The effect of acti-vation of 5-HT2A R on the principal neuron and inter-neuron firing rates was examined with multichannel re-cording. Results 5-HT2A R immunoreactivity was ob-served in the dCA1 neurons, including rough endoplas-mic reticula and mitochondria, and the 5-HT2A R and glutamate NMDA receptors were colocalized in the syn-aptic membrane, vesicle and neurofilament of the hipp-ocampal neuron. 5-HT2A R activation increased princi-pal neuronal firing rate and the interneuronal firing rate was not changed. Conclusion The 5-HT2A R and NM-DA receptor are colocalized in dCA1 neurons, and acti-vation of 5-HT2A R increases hippocampal principal neuronal firing rate.