Objective: To investigate the morphological changes of cerebral blood vessels by digital subtraction angiography (DSA) in patients with central vertigo, so as to provide references for diagnosis and treatment of patients with central vertigo. Methods: Ninety-two patients suffering from central vertigo were subjected to cerebral angiography through femoral artery. The types, proportion, and distribution (site predilection and number of involved vessels) of the cerebrovascular abnormalities were observed and analyzed. Results: Of the 92 patients with central vertigo, cerebrovascular lesions were found in 137 sides, including 15 (10. 95%) anterior circulation lesions and 122 (89.05%) posterior circulation lesions. Thirty-one (33.7%) patients had 2 or more lesions. The most common lesion was vertibroarterial lesion accompanied with other cerebrovascular stenosis. The lesions included 39 (28.47%) sides with vertibro-basilar stenosis or occlusion, 13 (9.49%) sides with posterior cerebral artery stenosis or occlusion, and 59 (43.06%) sides with posterior circulation abnormalities. Conclusion: The posterior circulation stenoses or abnormalities might be the major reasons for central vertigo in middle- and old-age patients.

In recent years,more and more researchers have realized the possibility that algicidal bacteria could be a useful tool in reducing the impact of harmful algae blooms. In this review, the ecological roles of algicidal substances was briefly discussed, then special emphasis placed on the categories and extract methods of algicidal substances which have been reported. Some ideas for the further studies on algicidal substances were also proposed.

Objective To find out nutrient support drug utilization in cancer patients in our hospital. Methods An analysis was made by means of drug utilization research into the structure and rationality of nutrient support drug utilization in our hospital through an investigation into the detailed records of the dispensary from 1999 to 2002 and into 1 014 medical records from 2002. Results The variety, quantity, and cost of nutrient support drug utilization in the four years rose respectively by 58.82%, 71.66% and 28.16%. 49.30% of the cancer patients whose medical records were surveyed used such drugs. The quantity and person time ratio of PN and EN drug utilization was respectively 14∶1 and 13∶1, with malnourished patients accounting for 19.80%. Of the PN drugs whose DDD value could be determined, most had a DUI value that was greater than 1 whereas most of the EN drugs had a DUI value which was smaller than 1. Conclusion The variety, quantity, and cost of nutrient support drug utilization in the four years rose rapidly. The quantity and person time of PN drug utilization were much higher than those of EN drug utilization. Doubts could be cast in the handling of indications for nutrient support drug utilization in some patients and the doses of some nutrient support drugs prescribed were not so rational. Further explorations need to be made into the rational application of nutrient support treatment.

[Objective]To review the antitumor progress of Raddeanin A in nearly 10 years. [Method] Col ecting the antitumor research literature about Raddeanin A for nearly 10 years, describing its antitumor research mechanism, such as inducting of cellapoptosis blocking the cellcycle, blocking STATs signaling pathways and inhibiting the tumor angiogenesis. [Result] Raddeanin A could induce the H460 cellapoptosis, block LoVo cellcycle and STATs signaling pathways of LoVo cells, and inhibit HepG-2 cellangiogenesis. [Conclusion] The antitumor mechanism of Raddeanin A could be inducting of cellapoptosis, blocking the cellcycle, blocking STATs signaling pathways and inhibiting the tumor angiogenesis.

Objective To approach the effect of prosthetic valve at preventing reflux esophagitis.Methods After the total gastrectomy and esophagojejunostomy,interrupted suture was apphed to form a prosthetic valve at output and input beyond Braun's stoma.Results Only one got light reflux esophagitis in 15 patients.Conclusion Prosthetic valve can prevent reflux esophagitis,and the operation is convenient and safe,which is deserved to be in generalization and approach the latest method.

Objective To study the effect of chronic electrical stimulus at a low physiological frequency on the expression of myosin heavy chain (MHC) in genioglossus of rabbits with chronic hypoxia.Methods Twenty-four adult rabbits,weighing 2.3?0.1kg,were randomized into control group (A),chronic hypoxia group (B),10 Hz electrical stimulus group (C),and 10+40 Hz electrical stimulus group (D).Rabbits in groups C and D received electrical stimulus of genioglossus at a frequency of 10 Hz and 10+40 Hz,respectively,while those in group B received no electrical stimulus,after they were placed in a hypobaric hypoxia cabin,8 h a day for 5 weeks,with free access to food and water.Expression of MHC in genioglossus of rabbits in the 4 groups was detected by SDS-PAGE and semi-quantitative inverse transcription RT-PCR,respectively.Results The expression level of MHCⅠand MHCⅠmRNA was significantly lower while that of MHCⅡa was significantly higher in group B than in group A [(0.69?0.07)% vs (17.48?4.00)%,(0.69?0.07)% vs (1.05?0.06)%,and (79.89?5.09)% vs (73.33?4.17)%,P

OBJECTIVETo observe thee efficacy of different ways of percutaneous coronary intervention (PCI) for treating elderly coronary heart disease (CHD) patients.

METHODSTotally 470 elderly CHD patients were classified to three age brackets (equal to or more than 85 years old, 60 to 74 years old, 75 to 84 years old). They were assigned to the transradial intervention (TRI) group (236 cases) and the transfemoral intervention (TFI) group (234 cases) according to different intervention pathways. Correlated indices and postoperative clinical efficacy were compared between the two groups.

RESULTSA higher successful rate of surgery was obviously got in patients 85 years old or older than 85 than in those 60 to 74 years old and 75 to 84 years old (P <0. 05). The incidence of major cardiovascular events (MACE) was reduced at post-operative 12 and 24 months in patients 85 years old or older than 85 (P <0. 05). The case number for changing intervention pathway were increased in the TRI group with statistical difference (P <0. 05). Compared with the TFI group, the case number for changing intervention pathway was increased; the time for arteriopuncture, the time for catheterization, and the time for X-ray exposure were prolonged; the time for postoperative bedding were obviously shortened; the incidence of vascular complications at the puncture site were lowered. The incidence of postoperative 12-month MACE was lowered, all with statistical difference (all P <0. 05). The incidence of MACE within postoperative 24-month MACE decreased in patients 60 to 74 years old and 75 to 84 years old (P <0. 05). The incidence of MACE within postoperative 24 months increased in patients 85 years old or older than 85 of the TRI group with statistical difference (P <0. 05).

CONCLUSIONTRI can be preferably chosen for PC in treating elderly CHD patients.

Aged ; Aged, 80 and over ; Coronary Artery Disease ; surgery ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Myocardial Infarction ; Percutaneous Coronary Intervention ; methods ; Radial Artery ; Treatment Outcome

?Objective:To investigate the behavior of absorbable coral hydroxyapatite (Interpore 500R) as bone tissue engineering scaffold. Methods: Marrow stromal stem cells harvested from legally aborted human fetus were cultured in DMEM containing 100 ml/L fetal boving serum and induced to differentiate towards osteoblasts.Then the cells were seeded onto absorbable coral hydroxyapatite , then the composite was implanted subcultaneously into the back of nude mice .Cell materia attachement was observed with scanning electron microscope,type I collegen secretion was studied with laser confocal microscope and new bone formation was studied histologicaley. Results: The cells could adhere to absorbable coral hydroxyapatite and secrete collagen I.Mature bone tissue was found in the implanted composite 40 day after transplantation. Conclusion: Absorbable coral hydroxyapatite Interpore 500R is a favorable bone tissue engineering scaffold.

Objective To analyze the MRI features of Hirayama disease(HD)with cervical natural position and its diagnostic val-ue.Methods The natural position of cervical vertebra with MRI examination was used in 1 5 patients and 40 normal people.The spe-cificity and sensitivity of MRI features were analyzed and the ratio of cervical sagittal diameter/cervical transverse diameter (CSD/CTD)of the lower cervical cord was measured.Results CSD/CTD of the patients and control group had a significant difference (t=7.99,P =0.00).The sensitivity of LOA was 86.7%,and its specificity was 88.4%.The sensitivity of atrophy of the lower cervical cord was 80.0%,and its specificity was 79.5%.The sensitivity of the cervical spine curvature abnormalities was 40.0%,and its spe-cificity was 65.2%.The sensitivity of abnormal signal in the spinal cord was 46.7%,and its specificity was 87.5%.The sensitivity of abnormal signal in the epidural outer cavity was 20.0%,and its specificity was 96.8%.Conclusion MRI features of lower cervical cord in combination with clinical symptoms and signs can be helpful for the accurate diagnosis of HD.

Objective To study the clinical characteristics of lymphatic malformation(LM).Methods Clinical data of 14 cases with LM were analysed and literatures were reviewed.Results ①Among the 14 cases,6 were diagnosed as primary intestinal lymphangiectasia(PIL)and 8 as primary lymphedema(PL);②The major manifestations of PIL are symmetry edema,diarrhea,lymphocytopenia,hypoproteinemia and chylopericardium.The manifestations of PL included asymmetry edema of lower limbs and respiratory symptoms;③Directed oil-contrast lymphography and isotope techniques demonstrated absence of contrast in some lymphatic segments and blockage of chylous reflux;④White opaque spots were found on the duodenal and intestinal mucosa in the endoscopy of 6 cases of PIL indicating lacteal vessels dilation.Pathological examinations revealed intestinal lymphangiectasia;⑤Six cases of 14 patients were treated with surgical therapy and 8 cases were treated with conservative therapy including medium chain triglyceride(MCT).Conclusion LM should be diagnosed on the bases of typical clinical manifestations specific laboratory findings and by lymphography and pathology.Combination of surgical therapy and conservative therapy is recommended to treat the LM patients.