OBJECTIVE:To provide reference for rational drug use. METHODS:107 patients with drug-induced liver injury (DILI)admitted to liver disease department of our hospital during Jan. 2011 to Dec. 2015 were divided into TCM group and chemi-cal medicine group according to the type of medicine. DILI clinical characteristics,prognosis,medicine types of DILI were com-pared and analyzed between 2 groups. RESULTS:47 cases of DILI were induced by TCM,which mainly were health care and body beauty medicines(19.1%),rheumatism and arthritis medicines(14.9%)and dermatological medicines(10.6%). 60 cases of DILI were induced by chemical medicine,which mainly were antineoplastics(21.7%),antimicrobial(20.0%)and antituberculot-ics (11.7%). Gender,average age,the time from primary medication to disease attack and clinical classification were no signifi-cant difference between 2 groups(P>0.05). The clinical manifestations of the 2 groups were similar,except that fatigue was more common in the TCM group,with statistical significance(P<0.05). The liver function indicators of TCM group as ALT,AST, TBIL and ALP were higher than those of chemical medicine group,while ALT and TBIL were significantly different between 2 groups(P<0.05). The liver injuries were more serious in the TCM group than in chemical medicine group,with statistical signifi-cance(P<0.05). After treatment,the prognosis and the prognosis of liver function indicator in 2 groups were not statistically sig-nificant(P>0.05). CONCLUSIONS:Doctors and pharmacists should cooperate to master medication indication strictly,develop ADR monitoring and conduct blood concentration monitoring of high-risk DILI medicines,especially the hepatotoxicity of TCM so as to reduce the occurrence of DILI and guarantee the safety of clinical drug use.

Medicine, Chinese Traditional ; Translations

Henoch Sch?nlein purpura( HSP) is a vasculitis of primary systemic vascular lesions of aller-gic diseases in children. Henoch Schonlein purpura nephritis( HSPN) is the most common allergic purpura sec-ondary renal disease,hematuria and(or)proteinuria of allergic in purpura the course(the most six months) can make diagnosis. The clinical manifestations varyies in severity,and the incidence has increased year by year,the incidence may be related to infections, allergies, immune abnormalities, immune damage and so on. So raising awareness of children nephritis,early diagnosis,early treatment has a great impact on the prognosis of children.

[Objective]To study the effect of tibial diaphyseal lengthening on the longitudinal growth of the tibia.[Method]Rabbit models of tibial diaphyseal lengthening and tibial osteotomy were established.Standard radiography of the tibia was taken and the length of the tibia was measured.Histology of the proximal and distal tibia was made and the thickness of the growth plate was measured.[Result]Tibial osteotomy alone stimulated the longitudinal growth of the tibia and increased the thickness of the growth plate.However,tibial diaphyseal lengthening suppressed this stimulation resulting in natural longitudinal growth and normal thickness of the growth plate that matched the normal side.[Conclusion]Diaphyseal lengthening of tibia does not inhibit the longitudinal growth of the tibia.

Air Pollutants ; Cardiovascular Diseases ; epidemiology ; Humans ; Particulate Matter

The effect of molecular cytogenetics in pathogenesis of multiple myeloma (MM) is fundamental.The risk stratification system that based on molecular cytogenetics of MM is widely applicable in the prognosis of MM.The aberration of molecular cytogenetics is the most important marker of MM.At the same time,high-risk MM is associated with intra-clonal tumor heterogeneity and clonal evolution.The research of intra-clonal tumor heterogeneity and clonal evolution which based on the aberration of molecular cytogenetics will provide some additional information of the biology of MM and contribute to the optimum treatment for MM patients.

Objective In order to evaluate the efficacy of Diammonium Glycyrrhizinate in the treatment of chronic hepatitis B. Methods The randomized clinical trials(RCTs) that compared the efficacy of Diammonium Glycyrrhizinate and other kind of treatment in chronic hepatitis-B were chosen from CBM disks from 1995 to 2004 and CNKI from 1995 to 2004.A meta-analysis was employed to evaluate the results of these therapies. Results Twenty-four RCTs including 3201 cases were analyzed.Compared with control group,the total RR of efficiency rate of Diammonium Glycyrrhizinate group were 1.378(95%CI 1.243～1.529),showing significant difference(P

[Objective]To explore the method and effect of elbow joint distraction arthroplasty in the treatment of post-traumatic elbow joint flexion contracture.[Method]An Ilizarov ring distractor of elbow joint was designed.From March 2003 to July 2005,three cases of elbow joint flexion contracture aged 16～17 years (one male and two females) with a flexion deformity of 70? in one case and 45? in two cases were treated.The joint distractor was applied with the wires in the upper limb and the joint hinge at the rotational centre of the elbow joint.No skin incision was made.To correct the deformity gradually,a continuous distraction force was applied by turning the nut on the distraction bar and periodic X-ray films were taken to confirm the position of the elbow joint.[Result]The elbow joint was finally extended to 0?～10?with an average 45?correction of flexion after an average 32 days of distraction.The range of elbow joint movement increased from pre-operative 75?to post-operative 115?.[Conclusion]The elbow joint distraction arthroplasty is effective in the correcting of the elbow joint flexion contracture and improving of joint function.

[Objective]To explore the apparatus assembly,operative methods,post-operative management procedure and the effect of Ilizarov's technique of distraction histogenesis to correct the severe compound knee joint deformities (more than two deformities of knee joint such as knee flexion contracture with genu varus and limb shortening).[Method]According to Ilizarov technique of distraction histogenesis,three dimensional knee joint distraction apparatus together with limb lengthening accessories for simultaneous lengthening of the lower limb were designed.In accordance with different types of compound knee joint deformities and the positions of skeletal deformities,across knee joint distraction apparatus was applied with simultaneous distal femoral or proximal tibial osteotomy.Soft tissue contracture of knee joint along with co-existing skeletal deformity and shortening were simultaneously corrected by slowly turning the corresponding distraction rods at seven days after the operation.During the period of distraction,patients can walk with partial weight bearing.After healing of the distraction bone regenerate,the distraction apparatus was removed and the knee joint brace applied for the patients to walk for about 3～6 months.From May 1996 to Feb 2004,compound knee joint deformities were corrected in 14 patients aged between 5 and 41 years old with an average age of 27 years and etiologies of 7 kinds,in whom four cases had developmental deformities of the knee joint caused by epiphyseal injury or infection in infancy and ten cases caused by other reasons.[Result]The time of joint distracting and bone healing was 80~390 d,average 154 d.All cases had satisfactory correction of severe compound knee joint deformities such as knee flexion contracture,genu varus,genu valgus,limb shortening and rotational deformity with good walking function.None had complications such as severe pin tract infection,injury to blood vessels and nerves and non-union.But a different extent of knee joint stiffness occurred.[Conclusion]Ilizarov technique of distraction histogenesis can be used to correct severe compound knee joint deformities and limb length inequality.It follows with biological principles,makes achievements unattained by traditional orthopedic surgery and have good prospect of application.

[Objective] According to the basic principle of Ilizarov technique,the apparatus assembly,indications,operation methods and clinical effectiveness of Ilizarov technique in the correction of foot and ankle deformities were explored.[Method]In accordance with pathological changes and requirements for correctioning talipes equinus,cavus,calcaneus and forefoot varus or valgus,four standard external fixators were designed on the basis of Ilizarov apparatus assembly and tested biomechanically to correct the above four foot deformities.The innovation had expanded Ilizarov technique to correcting scar talipes equinus and severe foot valgus caused by rheumatoid arthritis and congenital fibular deficiency.[Result]The clinical applications of the four kinds of external fixators showed reasonable apparatus structure,convenient installation and adequate adjustment of distraction tension.They had been used in 105 cases and achieved satisfactory correction of deformity and functional recovery without severe complications.[Conclusion]The four new assemblies of external fixators showed simple structures,good performance,and practicality.Ilizarov technique has played an irreplaceable role in the correction of severe foot and ankle deformities.