Congenital heart disease is the most common birth defect.With the significant improvements of cardiac surgical techniques,the survival of newborns and infants with complex congenital heart disease(CHD) has obviously been increased.However,neurological sequelae are still common and up to 25 ％ ～50％.The most important lesion after CHD surgery is white matter(WM) injury.Recent studies show that periventricular leukomalacia disease characterized by WM injury is common in C-HD infants especially after cardiac surgery.It is previously thought to be due to the cardiopulmonary bypass and surgical operation.However,with the advances in surgery and medical diagnostic technology and development of basic research in recent years,it is discovered that WM injury in infants with CHD is a complex lesion influenced by preoperative,operating and postoperative factors.The movement disorders and the defects of attention,learning and other aspects in the late growth of these children bring a huge economic burden to the family and society,reducing the quality of the population.Therefore,exploring etiology,mechanisms and control methods of WM injury in infants with CHD becomes a hot topic in recent years,and it may also become an important direction for future research,aiming to the significant improvements in CHD children with neurodevelopmental damages.

Objective To study the clinical effect on C-IBS treated with tegaserod and bifico combined. Methods 156 patients were randomly divided into one therapy group (group A) and two control group (group B, group C). Patients in the group A were given tegaserod and bifico therapy, while those in group B were given tegaserod therapy and group C were given bifico therapy. Results After 4 weeks' clinical treatment, the rates of remission were 94.6% in group A,7 9.1 % in group B and 54.2% in group C. There were significant statistical differences among three groups(P

Humans ; Male ; Middle Aged ; Neoplasms, Radiation-Induced ; etiology ; Occupational Diseases ; etiology

AIM: To study the effects of chromium rutin synthesized with rutin and chromium (Ⅲ) on metabolism of blood lipid. METHODS: The effects of chromium rutin on metabolism of blood lipid were evaluated by the changes of triglyceride, cholesterol, HDL cholesterol, and LDL cholesterol in normal rats and the rats with high blood lipid. RESULTS: Chromium rutin could increase the blood chromium, decrease the concentrations of triglyceride, cholesterlo and LDL cholestelol,and increase the concentration of HDL cholesterol in normal and the rats with high blood lipid rats. CONCLUSION: Chromium rutin has an effect on the blood lipid in rats.

Cryptococcus neoformans(CN) is a kind of opportunistic fungal pathogen which has a predilection for the central nervous system,resulting in devastating meningitis.The management of cryptococcal meningitis remains challenging because of its high mortality,the toxicity and uncertainty effect of antifungal therapy.In recent years,the study of the mechanism of neurotropism of CN has made a great progress.Many violence factors of this pathogen and several signal pathways of the host involved in this process have been discovered.Combination therapy with immunotherapy to regular antifungal treatment has become an important adjuvant method.The present review will concisely present current progress of pathogenesis and immunotherapy of cryptococcal meningitis.

[Objective] To investigate the effect of electroacupuncture (EA) of Neiguan (PC6) poinl on rnyocardial fibrosis and myocardial contents of collagen type Ⅰ and type Ⅲ in rats with pressure overload. [ Methods ] Rats were randomized to four groups: pseudo-operation group ( group A), model group ( group B) , EA group ( group C) and western medicine group (group D). Pressure-overloaded rat models were established by restriction of abdominal aortic artery. Left ventricular mass index (LVMI) and blood pressure (BP) in the four groups were observed; the plasma level of angiotensin Ⅱ (Ang Ⅱ ) was detected by radioimmunoassay and myocardial contents of collagen type Ⅰ and type Ⅲ by immunohistochemical staining method. [Results] BP, LVMI, expression levels of Ang If and collagen type Ⅰ and type Ⅲ were increased in group B as compared with those in group A ( P 0.05) . [Conclusion] EA of Neiguan point is effective in preventing and treating myocardial fibrosis induced by pressure overload.

The configuration of the air cleaner and operating principle of high-voltage static electrical field (HVEF) are introduced. The primary bactericidal mechanism and broad-spectrum effect are also mentioned.

Objective To explore the clinical significance of granuloma in Crohn's disease through the comparison of the clinical features between the groups with and without granuloma.Methods Seventy-five patients,hospitalized in Peking Union Medical College Hospital from 1995 to 2005,were retrospectively analysed.Results Compared with the nongranuloma group,the granuloma group shows increased disease activity,more frequent usage of immunosuppressant,higher operation rate and more postoperation complications.Conclusions Granuloma may be an index of the severity of disease activity in Crohn's disease.

Objective:To investigate the operation technique and the effect of the posterior microendoscopic discectomy (MED) system on lumbar intervertebral disc hermiation (LIDH). Methods: We retrospectively reviewed and analyzed 25 cases of LVDH treated with the MED system from March 2004 to August 2005. Results: All the patients were ambulant 20 hours to 7 days (mean 2.4 days) after the operation, with a mean hospital stay of 5.2 days. And all were healed within the first stage except 1 case of infection. The patients were followed for 2-15 months (mean 6 months). Excellent results were achieved in 18 cases, good results in 5 and fairly good results in 2, the first two groups making up 92%. Conclusion: The key to successful MED with no complications is familiarity with the equipment, proper choice of indication, exact surgical location and skilful operation.

Objective To investigate the clinical effect of intravenous infusion of dextral metomidine and the analgesia of epidural injection.MethodsAccording to the different ways of labor analgesia will be selected in January 2015 to January 2017 in our hospital childbirth puerpera 120 cases are grouped into: the control group with regular continuous epidural analgesia injection way, observation group with intravenous infusion set beauty holds the mi + right regularity discontinuous epidural analgesic injection mode;Record two groups of patients with various experiment data, and will make an analysis of data obtained, conclusion intravenous infusion set right beauty holds the mi joint regularity the clinical effect of continuous epidural labor analgesia injection.ResultsIntravenous right beauty holds the mi + regularity discontinuous epidural injection way for puerpera childbirth analgesia effect is superior to the pure regularity discontinuous epidural injection way analgesia effect, compare the difference between groups was statistically significant (P<0.05).Conclusionpregnant women choosing to analgesia vein infusion set beauty holds the mi + right regularity discontinuous epidural analgesic injection way, clinical analgesic effect is good, will not cause great influence to own and maternal newborn, worth clinical widely used for childbirth analgesia.