Humans ; Male ; Middle Aged ; Neoplasms, Radiation-Induced ; etiology ; Occupational Diseases ; etiology

Objective To study the clinical effect on C-IBS treated with tegaserod and bifico combined. Methods 156 patients were randomly divided into one therapy group (group A) and two control group (group B, group C). Patients in the group A were given tegaserod and bifico therapy, while those in group B were given tegaserod therapy and group C were given bifico therapy. Results After 4 weeks' clinical treatment, the rates of remission were 94.6% in group A,7 9.1 % in group B and 54.2% in group C. There were significant statistical differences among three groups(P

Congenital heart disease is the most common birth defect.With the significant improvements of cardiac surgical techniques,the survival of newborns and infants with complex congenital heart disease(CHD) has obviously been increased.However,neurological sequelae are still common and up to 25 ％ ～50％.The most important lesion after CHD surgery is white matter(WM) injury.Recent studies show that periventricular leukomalacia disease characterized by WM injury is common in C-HD infants especially after cardiac surgery.It is previously thought to be due to the cardiopulmonary bypass and surgical operation.However,with the advances in surgery and medical diagnostic technology and development of basic research in recent years,it is discovered that WM injury in infants with CHD is a complex lesion influenced by preoperative,operating and postoperative factors.The movement disorders and the defects of attention,learning and other aspects in the late growth of these children bring a huge economic burden to the family and society,reducing the quality of the population.Therefore,exploring etiology,mechanisms and control methods of WM injury in infants with CHD becomes a hot topic in recent years,and it may also become an important direction for future research,aiming to the significant improvements in CHD children with neurodevelopmental damages.

Cryptococcus neoformans(CN) is a kind of opportunistic fungal pathogen which has a predilection for the central nervous system,resulting in devastating meningitis.The management of cryptococcal meningitis remains challenging because of its high mortality,the toxicity and uncertainty effect of antifungal therapy.In recent years,the study of the mechanism of neurotropism of CN has made a great progress.Many violence factors of this pathogen and several signal pathways of the host involved in this process have been discovered.Combination therapy with immunotherapy to regular antifungal treatment has become an important adjuvant method.The present review will concisely present current progress of pathogenesis and immunotherapy of cryptococcal meningitis.

AIM: To study the effects of chromium rutin synthesized with rutin and chromium (Ⅲ) on metabolism of blood lipid. METHODS: The effects of chromium rutin on metabolism of blood lipid were evaluated by the changes of triglyceride, cholesterol, HDL cholesterol, and LDL cholesterol in normal rats and the rats with high blood lipid. RESULTS: Chromium rutin could increase the blood chromium, decrease the concentrations of triglyceride, cholesterlo and LDL cholestelol,and increase the concentration of HDL cholesterol in normal and the rats with high blood lipid rats. CONCLUSION: Chromium rutin has an effect on the blood lipid in rats.

Objective To purify and quantify the autoantibodies against various epitopes within BP180-NC16A domain from the sera of patients with bullous pemphigoid (BP). Methods Three epitopes within BP180-NC16A domain, NC16A-1, NC16A-2 and NC16A-3, were prepared. Blood samples were obtained from 10 patients who were diagnosed as active BP by clinical, pathological and immunofluorescence examination. Autoantibodies against these epitopes were purified with affinity chromatography column from the sera of these patients with active BP, and quantified separately. The relative binding affinity of autoantibodies to NC 16A-1, NC 16A-2 and NC 16A-3 was measured using thiocyanate elution method. Results The autoantibodies against NC16A-1, NC16A-2 and NC16A-3 were successfully purified from the sera of patients. On average, the amount was 49.0±20.7 μg, 117.7±22.4 μg and 39.5±18.9 μg respectively for autoantibodies to NCI6A-1, NC16A-2 and NC16A-3 purified from a portion of serum containing about 20 mg IgG. Both the amount and binding affinity of anti-NC16A-2 autoantibody were significantly higher than those of anti-NC16A-1 and anti-NC16A-3 autoantibodies. Conclusion BP180 NC16A-2 (aa507-aa520) may be the major epitope recognized by pathogenic autoantibodies in patients with BP.

Autofluorescence has great advantage on detecting premalignant lesions and early cancers which are not detectable by conventional white light endoscopy (WLE). In this review, the recent advances in autofluorescence for diagnosis of precancerous lesions and early cancers are presented. Varieties of endogenous fluorophores in biological tissues, the potential mechanisms of the autofluorescence differences between normal and abnormal tissues, the selection of light source and optimal excitation wavelengths, and effective algorithms for processing autofluorescence data are highlighted. Finally, the shortages and improvement directions of autofluorescence technique for the diagnosis of precancerous lesions and early cancers are briefly discussed.
Early Detection of Cancer ; methods ; Esophageal Neoplasms ; diagnosis ; Fluorescence ; Humans

Encephalocele ; pathology ; Granulomatosis with Polyangiitis ; pathology ; Histiocytosis, Sinus ; pathology ; Humans ; Otorhinolaryngologic Diseases ; pathology ; Pathology ; trends ; Precancerous Conditions ; pathology ; Tuberculosis, Laryngeal ; pathology

Objective:To observe the effect of the signaling pathway of protein kinase C (PKC)-nuclear factor-erythroid 2-related factor 2 (Nrf2) on the expression of heme oxygenase -1 (HO-1) induced by cigarette smoke extract in rat airway epithelial cells.Methods:The airway epithelial cells of 25 male SD rats were randomly divided into a control group, a CSE3h group, a RO318220 group (PKC inhibitor), a Nrf2 siRNA group and a Nrf2 siRNA+RO318220 group, 5 rats in each group. hTe control group was incubated with DMEM/F12 alone. hTe CSE3h group was treated with 10% CSE for 3 h. hTe RO318220 group was pretreated with 3 μmol/L RO318220 for 0.5 h and subsequently treated with 10% CSE for 3 h. hTe Nrf2 siRNA group was pretreated with Nrf2 siRNA, and then treated with 10% CSE for 3 h. hTe Nrf2 siRNA+RO318220 group was pretreated with Nrf2 siRNA and 3 μmol/L RO318220 for 0.5 h, and then treated with 10% CSE for 3 h. hTe protein levels of Nrf2 in the nucleus and cytoplasm, and HO-1 and PKC in the whole cells were semi-quantified by Western blot. The protein expression of HO-1 was measured by immunocytochemistry. HO-1 mRNA expression was detected by RT-PCR. Immunolfuorescence staining was used to observe the nuclear translocatin of Nrf2. Results: CSE markedly induced Nrf2 nuclear translocation in the rat airway epithelial cells, and RO318220 pretreatment blocked the CSE induced Nrf2 nuclear translocation. Immunocytochemistry showed that HO-1 protein expression was strongly positive in the CSE3h group, weakly positive in the other 4 groups. hTe expression of PKC protein, HO-1 mRNA and protein signiifcantly increased in the CSE3h group, and HO-1 activity markedly improved in the CSE group (P<0.05). hTe level of PKC protein expression was not signiifcantly different in the Nrf2 siRNA group compared with that in the CSE3h group (P>0.05). Conclusion: CSE induces the nuclear translocation of Nrf2 by PKC signaling pathway, thus upregulating the HO-1 expression in the rat airway epithelial cells.

This paper stated the design of DPK colour LCD module and its application for the medical instrument. The hardware interface between MCS-51 and DPK LCD module is presented and the software driver base on KeilC51 language is introduced in this paper. The LCD module is well used in the "Cerebral oximeter for the newborn".