Objective To review a treatment of Tile B and Tile C Morel-Lavallée lesions with a texas scottish rite hospital (TSRH) and external fixation.Methods From September 2008 to September 2013,21 patients were operated with a treatment with TSRH system and external fixation.Results Those 21 cases were followed up from 12 to 24 months with an average of 15.8 months.All fractures were healed without osteomyelitis and patients showed no sing of limp.The rate of good recovery was reached 80.9％(17/21).Conclusions Internal fixation with TSRH system and external fixation for treating Tile B and Tile C Morel-Lavallée lesions can result in a high success rate.

In experimental teaching of medical physiology for medical students,simulation experiment,which is developed from animal substitute and animal protection,can mimic animal ex-periments by multiple medias,and result in increasing students' study interests,enhancing the teaching effects and decreasing the cost of goods including experiment animals.However,the ratio of simulation experiment to experimental teaching of medical physiology needs to be discussed and determined in future.

Over the past several decades of innovation and development, Ilizarov technique has been widely recognized and applied in correction of limb deformity and post-traumatic sequelae with outstanding clinical outcomes, which making remarkable contributions to the development of orthopaedics. There is no doubt that tissue regeneration induced by tension-stress is the core of Ilizarov technique, and a series of biological cascades contributing to tissue regeneration could be triggered by mechanical stimulation through signal transduction including bone morphogenetic proteins regulations, inflammatory responses and immune responses, angiogenic activities, stem/progenitor cell homing and other systematic effects. One of main limitations of Ilizarov technique is slow rate of new bone mineralization. To facilitate this technique application better in clinical practices, a multitude of researches of means for promoting bone mineralization have become hot spots in this field in recent years, such as physical measures, chemicals and biological therapies. With better understanding of distraction histogenesis for promoting tissue regeneration, transverse tibial bone transport has been increasingly applied to vascular disease management in lower extremity, such as diabetic foot and thromboangitis obliterans. This review focuses on the recent advances in understanding the basic biological mechanisms of Ilizarov technique and new methods for promoting bone consolidation in distraction areas, providing evidence and ideas for further mechanism investigations and approach innovations.

Child ; Humans ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; therapy

Objective To investigate the significance of cortactin in primary liver cancer. Methods Fiftythree paraffin embedded primary liver cancer specimens were collected at General Hospital of Air Force of PLA from January 2002 to May 2008. The expression of cortactin was detected by immunohistochemistry, and the relationship between cortactin expression and clinicopathologic parameters was analyzed. All data were analyzed via Wilcoxon rank sum test and Spearman rank correlation analysis. Results There was a significant difference in cortactin expression among tumor capsule integrity, TNM staging, portal vein tumor thrombus and extrahepatic metastasis (u =2. 19, 3. 584, 2. 796, P ＜ 0.05 ). There was a positive correlation between tumor invasion and cortactin expression ( r = 0. 5794, P ＜ 0.05 ). Conclusions Overexpression of cortactin may be one of the factors enhancing the invasion of primary liver cancer. The level of cortactin expression can be used in evaluating the invasive potential of primary liver cancer.

Objective To study the clinical pathological features, treatment and prognosis of umbilical metastases of colorectal carcinoma. Methods From January 2000 to September 2010, 10 umbilical metastases of colorectal carcinoma cases were admitted. The clinical features were reviewed. Results Four radical resection of colon cancer and resection of the umbilical plexus metastases cases with chemotherapeutic intraperitoneal perfusion lived 9,11,14 and 18 months respectively, 1 ileum-transverse colon anastomosis case with chemotherapeutic intraperitoneal perfusion lived six months, 2 patients with systemic widely transfer and umbilical transfer with pure venous chemotherapy lived 3, 3.5 months respectively, 3 colon intra-operative cases with venous chemotherapy lived 5 ,5. 5 and 7 months respectively. Conclusion Surgical resection of the primary focal and periumbilical metastases can prolong survival time with adjunctive therapy.

Objective To establish an animal model of knee osteoarthritis (OA) , and to explore the relationship between cartilage degeneration and the expression of IL-1β and MMP-1. Methods A total of 16 healthy male rabbits (32 hind knee joints) were used. The experimental OA model was established in their left knees by intraarticular injection of0.2 ml of 4% papain solution and 0.1 ml of 0.03 mol/L L-cysteine solution. The right knees were used as the controls and were treated with intraarticular injection of 0.3 ml of normal saline solution. General and histological scoring, and IL-1β and MMP-1 expression intensity were compared between the 2 groups. Results The degree of cartilage degeneration in the left knees was higher than in the right knees as observed by naked eye and using an electron microscope. The left knees scored significantly higher than the right ones with Mankin's scoring system. There was significantly greater expression of IL-1β and MMP-1 in the chondrocytes of the left knees. Conclusions lntraarticular injection of papain and L-cysteine can induce experimental knee osteoarthritis in rabbits. The expression of IL-1β and MMP-I is significantly related with carti-lage degeneration.

Objective To investigate the effects of uhrashortwave therapy and passive motion on experimen-tal osteoarthritis caused by immobilization of the joint. Methods Twenty healthy male rabbits had their left knee joints fixed in extension for 4 weeks. They were randomly divided into 4 groups : a control group which did not receive any treatment, an uhrashortwave therapy group, a passive motion group, and an ultrashortwave therapy plus passive motion group, and treated accordingly for 4 weeks. The range of motion of the joint before and after treatment was compared in every group. At the end of the 4th week, all the rabbits were sacrificed, and the cartilage at the condylus medialis femoris was sampled and observed with toluidine blue staining, haematoxylin-eosin staining. Its gross appearance was noted and it was also analyzed using immunohistochemical techniques. Results ①Passive range of motion (PROM): there were no significant differences among the 4 groups before the treatment. Uhrashortwave therapy per se did not yield significant therapeutic effects in terms of PROM as compared to the controls, However, passive motion alone and in conjunction with ultrashortwave therapy brought about significant improvement of PROM when compared against the control group. The most significant change was seen in the integrated group, followed by the passive motion group. ②The histological scoring system : Mankin's scoring system showed significant differences a-mong all 4 groups. The highest value was the control group, which was followed by the ultrashortwave therapy group, the passive motion group and the integrated group. ③The positive expression rate of inducible nitric oxide synthase: there were significant differences among all 4 groups. The control group had the highest values, followed by the ultra-shortwave treated group, the passive motion treated group and the integrated group. Conclusions Ultrashortwave therapy, passive motion therapy and integrated therapy combining ultrashortwave therapy with passive motion can all can reduce and prevent the cataplasia of articular cartilage. Integrated therapy is the best treatment method, followed by passive motion therapy, and then uhrashortwave therapy.

Carcinoma, Non-Small-Cell Lung ; pathology ; surgery ; Humans ; Lung Neoplasms ; pathology ; surgery ; Neoplasm Staging ; Radiation Dosage ; Radiosurgery ; Treatment Outcome

To explore necessity on the preliminary scientific research quality training and ability cultivation in the clinical medicine undergraduate stage,and the experience and effect of starting paper writing training curriculum for clinical medicine undergraduate students.