1.Research progress on major pharmacological activities of S-allyl-L-cysteine
International Journal of Biomedical Engineering 2017;40(6):465-470
Oxidation and inflammation are associated with the pathological processes of most human diseases, posing a serious threat to human health. In recent years, researchers have extracted monomeric compounds from natural products for the prevention and treatments of diseases related to oxidation and inflammation. That has become a major trend in the study of anti-oxidant and anti-inflammatory drugs. Garlic, a natural product, has pharmacological activities such as anti-tumor, anti-inflammatory and detoxification and so on. Therefore, it is important to study and extract the active ingredients in garlic. As an active ingredient extracted from garlic, S-allyl-L-cysteine (SAC) has been extensively studied in cell and animal models. The main pharmacological activities of SAC and the related receptors were reviewed, and its mechanism of action in vivo and the beneficial effects on the corresponding diseases were summarized to provide the necessary basis for further study.
2.Selectively enhancing radiosensitivity of cancer cells
Yang GAO ; Jie GAO ; Ganen MU ; Yumin ZHANG ; Fan HUANG ; Wenxue ZHANG ; Chunhua REN ; Cuihong YANG ; Jianfeng LIU
Acta Pharmaceutica Sinica B 2020;10(12):2374-2383
The radiotherapy modulators used in clinic have disadvantages of high toxicity and low selectivity. For the first time, we used the