The required doses of gallamine (nondepolarizing neuromuscular bloeker) were measured in twelve patients under one MAC anesthesia of nitrous oxide-oxygen(50%)-enflurane with inductions of sodium pentothal (sleeping doses) and succinylcholine(1mg/kg). It was observed that the required dose of gallamine in nitrous oxide-oxygen(50%)-halothane (36. 5+/-3.54mg/hr/M2) is much higher than that in nitrous oxide-oxygen(50%)-enflurane (18.0+/-2.48mg/hr/M2) (p<0.01) and reviewed literaturea on the above result.
Anesthesia ; Enflurane* ; Gallamine Triethiodide ; Halothane* ; Humans ; Muscle Relaxation* ; Sodium ; Thiopental

An attempt was made to correlate the incidence of muscle pain following the administration of succinyIcholine and its prevention by prior administration of gallamine or d-tubocurarine. The overall incidence of pain after use of succinylcholine was 29 per cent. The prior injection of d-tubocurarine (0. 05 mg/kg) or gallamine (0. 3 mg/kg) completely pervented the muscle pain. It is presumed that d-tubocurarine or gallamine protects the patients from muscle pain by preventing a portion of the injected succinylcholine from depolarizing the muscle fibers.
Clinical Study* ; Gallamine Triethiodide ; Humans ; Incidence ; Myalgia ; Succinylcholine* ; Tubocurarine

Severe bronchospasm, hypotension and skin rash were observed in a 23 year-old woman after injection of gallamine iodide. Her past history revealed no asthmatic and allergic diathesis. Initial administration of succinylcholine induced a mild degree of bronchspasm and urticaria-like skin rash, which were intensified in severity after gallamine injection under the anesthetic state. Administration of hydrocortisone 500mg I.V. and antihistaminic(Avil), 100pmg I.M., produced successful relief of bronchospasm with circulatory embarrassment. A review was done as to histamine libration and bronchospasm due to succinylcholine, gallamine, d-tubocurarine, thiopental and atropine. The value of intradermal skin rash test was discussed.
Atropine ; Bronchial Spasm ; Disease Susceptibility ; Exanthema ; Female ; Gallamine Triethiodide ; Histamine ; Humans ; Hydrocortisone ; Hypotension ; Succinylcholine ; Thiopental ; Tubocurarine

That gallamine causes tachycardia during general anesthesia is well known, but the efficacy of its anticholinergic action or an adrenergic beta blocking action remains to be determined. Twelve patients were subjected to this study, in which under halothane anesthesia small doses of propranolol. an adrenergic beta-blocker, was administered. In all cases bradycardia resulted and the greatest decrease was noted five minutes after intravenous injection of propranolol(0. 5 1. 0mg). At the height of bradycardia, gallamine 80 mg was administered intravenously. In all cases gallamine produced a significant increase of heart rate over the level before the injection of propranolol, but not so much as without propranolol pretreatment. But fifth minute values after propranolol expressed as 100 per cent, (per cent change in heart rate after propranolol followed by gallamine,) and after gallamine were similar effectively. This study suggested that gallamine-induced tachycardia is modified, but its anticholinergic action is not impaired by propranolol, and that gallamine-induced tachycardia is caused by anticholiaergic action of gallamine.
Anesthesia* ; Anesthesia, General ; Bradycardia ; Gallamine Triethiodide ; Halothane* ; Heart Rate ; Humans ; Injections, Intravenous ; Propranolol* ; Tachycardia*

During the past three years, in 1,607 selected general anesthetic cases, the authors have observed the influence of various drugs used in anesthesia and the patient's physical status upon the blood pressure during and immediately following endotracheal intubation. The results are as follows: 1) Blood pressure was higher during and for a period of 10 minutes after intubation than the control. 2) In the cases premedicated with Demerol and atropine intubation. Following intubation, however, blood pressure halothane anesthesia. 3) In patients with poor physical status, blood pressure more following intubation when either halothane or ether was employed. 4) Patients with poor physical status seemed to tolerate, considering the blood pressure change, ether better than holothane anesthesia.5) In the beginning of induction, blood pressure tended to fall less with gallamine than with succinylcholine chloride.
Anesthesia ; Anesthesia, General* ; Atropine ; Blood Pressure* ; Ether ; Gallamine Triethiodide ; Halothane ; Humans ; Intubation ; Intubation, Intratracheal ; Meperidine ; Succinylcholine

Since succinyl choline was introduced, into clinical anesthesia, it has been used as main muscle relaxant because of its rare side effects and short duration of action. Our interest in the effects of this drug on extraocular muscles and intraocular pressure began in 1957 following reports of vitreous expulsion in patients who received succinylcholine during ocular surgery. The effects of muscle relaxants on the intraocular pressure were studied in 60 healthy human subjects. When succinylcholine was given alone, 20 human subjects had a mean increase in intraocular pressure of 10. 5 mmHg. When gallamine 2. 5 mg/kg or pancuronium 80 ug/kg was used, 20 subjects showed a mean decrease of 3. 1 mm Hg from control. Giving gallamine (20 mg) or dtubo curarine(3 mg) 2-3 minutes prior to the administration of succinylcholine, 20 human subjects had no significant change in intraocular pressure. This simple method prevents the increase in intraocular pressure associated with the use of succinylcholine.
Anesthesia ; Choline ; Gallamine Triethiodide ; Humans ; Intraocular Pressure* ; Methods ; Muscles ; Pancuronium ; Succinylcholine

The effects of skeletal muscle relaxants on skeletal muscle have been well known, but not the effects of these drugs on smooth muscle. In and attempt to study the effects of pancuronium, gallamine, succinylcholine, d-Tubocurrarine on siolated mongrel dog tracheal preparations, the writer has performed a set of experiment, of which results can be summarized as follows: 1) Pancuronium in dose of (r/cc) 3,10,30,100 produced dose dependent relaxation on Acetylcholine contraction. 2) Gallamine in dose of (r/cc) 30,100,300,1000 produced dose dependent relaxation on Acetylcholine contracction. 3) Succinylcholine in dose of (r/cc) 30,100,300,1000 produced dose dependent contraction on Acetylcholine contracction. 4) d-Tubocurarine in does of (r/cc) 30,100,300,1000 produced dose dependent contraction on Acetylcholine contracction. From the results described above, it can be concluded that pancuronium and gallamine had bronchodiating character and succinylcholine and d-Tubocurarine had bronchospastic character. But the clinical application of these results are still obscure.
Acetylcholine* ; Animals ; Dogs* ; Gallamine Triethiodide ; Muscle, Skeletal ; Muscle, Smooth ; Neuromuscular Agents ; Pancuronium ; Relaxation ; Succinylcholine ; Tubocurarine

To evaluate the historical trend of anesthetic experience for the past 22 years a total of 68,473 cases which were performed at the National Medical Center from 1959 to 1981 were studied. To simplify the analysis statistically, the author selected the anesthetic cases every other year(12 years). 1) General anesthesia was performed in more than 78% of the total cases and of this number endotracheal intubation has been used with increasing frequency(average 92.8%). 2) For intravenous induction, thiopental sodium was used as the main agent, in more than 90% since 1980. 3) Trichlorethylene, cyclopropane and ethylchloride which had been used since 1961, were abandoned from 1978 except for training purposes. Methoxyflurane was used from 1973 to 1979, but given up there after because of it's nephrotoxicity. The use of halothane has steadily increased(86% of the total inhalation anesthetics) and ethrane has also been used with increasing frequency since 1980. 4) Pancuronium has been used as a primary muscle relaxant instead of gallamine and D-tubocurarine which had been used as the main durgs from 1959 till 1979. 5) Innovar and morphine as intravenous anesthetics, have recently been with increasing grequency.
Anesthesia, General ; Anesthetics, Intravenous ; Enflurane ; Gallamine Triethiodide ; Halothane ; Inhalation ; Intubation, Intratracheal ; Methoxyflurane ; Morphine ; Pancuronium ; Thiopental ; Tubocurarine

To study the effects of small amounts of non-depolarizing neuromuscular blockers on the muscle fasciculation, postoperative muscle pains and relaxation time by succinylcholine, three groups of patients were pretreated with vecuronium (0.01 mg/kg), pancuronium (0.015 mg/kg) and gallamine (0, 2 mg/kg) 3 minutes before succinylcholine injection, respectively and compared their results with control group-saline pretreated group. The results are as follows; 1) Intensity of muscle fasciculation deereased significantly in all groups with non-depolarizing neuromuscular blockers, and frequency had the fewest in pancuronium pretreated group than the others. 2) Intensity of postoperative muscle pains decreased significantly in groups pretreated with pancuronium and gallamine, and frequency had the fewest in gallamine pretreated group than the others. 3) Pretreatment with non-depolarzing neuromuscular blocker had no effects on the onset time of muscle relaxation of succinylcholine but recovery of muscle relaxation by succinylchoine was more rapidly occured than control group. Above results, it will be suggest that gallamine and pancuronium can be used more effectively to prevent muscle fasciculation and postoperative muscle pain without influence on succinylcholine-induced muscle relaxation.
Fasciculation* ; Gallamine Triethiodide ; Humans ; Muscle Relaxation ; Myalgia ; Neuromuscular Blockade* ; Neuromuscular Blocking Agents* ; Pancuronium ; Relaxation* ; Succinylcholine* ; Vecuronium Bromide

Arterial pressure increased from normal to 80~90 mrn Hg, 90~100 mm Hg & 110 ~130 mmHg when the intracrania1 pressure was mechanically elevated to 20~40, mm Hg, 50~70 mm Hg & 90~l00mmHg respectively, while rabbits (average 3kg) were anesthetized with subcuttneous urethane, (1gm/kg), In these circumstances, there was no specific change in the intracranial pressure, or arterial pressure between two groups when one was given intravenous 5mg/kg of gallamine and the other 0. 5mg /kg of intravenous pancuronium. But in a group given 1mg/ kg of d-tubocurarine, arterial pressure decreased significantly, while intracranial pressure was not changed particularly arterial pressure decreased more significantly when the intracranial pressure was increased to 90~100 mm Hg, resulting in an initial arterial pressure of 110~130 mm Hg. Therefore the authors recommend. d-tubocurarine as the agent of choice among these three non-depolarizing muscle relaxants for induction and maintpnance of anesthesia in patients with elevated intracranial pressure pre-operatively.
Anesthesia ; Arterial Pressure ; Blood Pressure* ; Gallamine Triethiodide* ; Humans ; Intracranial Hypertension ; Intracranial Pressure* ; Neuromuscular Nondepolarizing Agents ; Pancuronium* ; Rabbits* ; Tubocurarine* ; Urethane