1.Effect of postoperative analgesia on rennin-angiotensin-aldosterone system in patients with coronary artery disease
Haizhong LI ; Gaiyun GAO ; Jun YANG
Chinese Journal of Primary Medicine and Pharmacy 2006;0(01):-
0.05).There were significant difference between pre-operation and after-operation in GA group(P
2.Clinical Observation of Small Dose of Octreotide for Preventing Hyperamylasemia and Acute Pancreatitis after Endoscopic Retrograde Cholangiopancreatography
Gaiyun GAO ; Jing LI ; Hongwei FAN ; Meng NI ; Xiao SUN
China Pharmacy 2017;28(8):1095-1097
OBJECTIVE:To observe clinical effects and safety of small dose of octreotide for preventing hyperamylasemia and acute pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP).METHODS:One hundred and twenty ERCP pa tients were selected from our hospital during Oct.2014-Jan.2015 and then divided in to observation group and control group in accordance with random number table,with 60 cases in each group.Both groups were given Diazepam tablet 10 mg+Meperidine hydrochloride tablet 100 mg+Phenobarbital scopolamine tablet 2 tablets 0.5 h before surgery for sedation and analgesia,and routine acid suppression and anti-infective therapy.Observation group was additionally given Octreotide acetate injection 0.1 mg hypodermically and then given Octreotide acetate injection 0.1 mg immediately after surgery,8 h after surgery.The levels of serum amylase and blood glucose were observed in 2 groups,and the occurrence of postoperative complication and ADR were recorded.RESULTS:Before operation,there was no statistical significance in the levels of serum amylase and blood glucose between 2 groups (P> 0.05).After operation,the level of serum amylase in control group was significantly higher than in observation group,with statistical significance (P<0.05).There was no statistical significance in blood glucose level between 2 groups after operation (P>0.05).The incidence of hyperamylasemia and ADR in observation group was significantly lower than in control group,with statistical significance (P<0.05),and there was no statistical significance in the incidence of acute pancreatitis between 2 groups after operation (P>0.05).CONCLUSIONS:Small dose of octreotide can effectively reduce the level of serum amylase and the incidence of hyperamylasemia after ERCP with good safety.