Objective:To explore the application effect of marital self-disclosure in young and middle-aged patients with early-stage lung cancer and their spouses.Methods:Using the convenient sampling method, a total of 86 patients with early-stage lung cancer who were admitted to the First Affiliated Hospital of Zhengzhou University from January 2018 to June 2019 were selected as the research objects. They were divided into the control group ( n=44) and the experimental group ( n=42) by random number table method. The experimental group was given marital self-disclosure intervention on the basis of routine nursing, while the control group was given routine nursing. Before and after the intervention, Self-rating Anxiety Scale (SAS) , Herth Hope Index (HHI) and Caregiver Reaction Assessment (CRA) were used to compare the effects of intervention. In the end, 39 valid data were obtained in the control group and 38 in the experimental group. Results:After the intervention, the SAS score of the experimental group was lower than that of the control group, and the difference was statistically significant ( P<0.05) . The scores of all dimensions of HHI in the experimental group were higher than those in the control group, and the differences were statistically significant ( P<0.05) . There were statistically significant differences between the two groups in the mean scores of dimensions of self-esteem, disturbed time schedule and lack of family support in spouse CRA ( P < 0.05) . There was no statistically significant difference in the mean score of health problems and economic problems in spouse CRA between the two groups ( P>0.05) . Conclusions:Marital self-disclosure intervention can effectively reduce the anxiety level of young and middle-aged patients with early-stage lung cancer, enhance the hope level of patients and reduce the caring pressure of the patients' spouses.