Objective To summarize and analyze the prevention and control model of colorectal cancer in Nanshan District, Shenzhen, and to provide references for other regions. Methods Based on the three-level prevention and control network in Nanshan District, top specialists from across the country and abroad were brought in serving as a technical support team to explore scientific and feasible early screening techniques and management models for colorectal cancer. Results Through a series of measures, such as government leadership, departmental cooperation, closed-loop management of the prevention and control services, health education and so on, the residents^' participation increased and health literacy was also improved. More than 20,000 residents participated in the risk assessment of colorectal cancer, and the positive detection rate was nearly 50% in people at a high risk. Conclusion The public health institution-community-hospital three-level prevention and control network was conducive to improving the compliance of residents with cancer screening, early detection and early intervention to reduce cancer morbidity and mortality.