Objective To research the effect of postoperative intervention on the quality of life of cervical cancer patients, in order to provide the basis for improve the quality of life of patients after operation. Methods 86 cases of cervical cancer were divided into control group and intervention group by simple random grouping method, each group contained 43 cases. The postoperative interventions were used in the intervention group after 3 months, including psychological assessment, individual education, pelvic floor rehabilitation therapy, open patient service hotline and regular follow-up. Before and after 6 months of surgery, the quality of life of cervical cancer patients were investigated. Results The index score of social relations [(48.84±4.63) scores vs. (40.72±3.74) scores], psychological field [(73.72±2.84) scores vs. (64.07±4.06) scores], environmental field [(64.07±4.08) scores vs. (55.70±4.86) scores], physiological index [(44.77±4.22) scores vs. (36.53±4.29) scores], independence [(64.81 ±5.85) scores vs. (53.95±5.91)], quality of life [(88.30±5.75) scores vs. (76.65±5.21) scores] in cervical cancer patients were lower than those in the control group (all P<0.05). Multiple stepwise regression analysis showed that the understanding degree of cervical cancer, radiotherapy and chemical therapy after surgery, postoperative complications, caregivers care in place and psychological intervention had correlation with the quality of life of patients in intervention group (all P<0.05), while retain ovarian and education degree had no correlation with the quality of life of patients after operation (both P>0.05). Conclusions The quality of life of cervical cancer patients after surgery is poor, and it is affected by many factors. The targeted interventions should be used in clinical works, which can significantly improve the quality of life of patients.

Objective:To explore the predictive value of serum 25-hydroxyvitamin D [25 (OH) D] and interleukin-6 (IL-6) levels in the development of osteoporosis (OP) in gestational diabetes mellitus (GDM) during early pregnancy.Methods:A total of 178 pregnant women with GDM admitted to Shanxi Provincial Children’s Hospital from Sep. 2018 to May. 2022 were selected as the research subjects and divided into OP group and non-OP group based on bone density. General information of patients was collected, and biochemical indicators related to bone metabolism were measured, including calcium (Ca), β-collagen special sequence ( β-CTX), type 1 procollagen amino-terminal peptide (PINP), n-terminal bone calciuim (N-MID), osteocalcin (OC), and bone alkaline phosphatase (BAP). The levels of 25 (OH) D and IL-6 in the serum of the two groups were measured. The predictive value of 25 (OH) D and IL-6 levels for GDM complicated with OP was analyzed. Results:Compared with the non-OP group (29.95±6.88), the serum 25 (OH) D level was significantly lower in the OP group (20.78±6.02) ( t=5.56, P<0.001), and the IL-6 level was significantly higher in the OP group (75.19±9.15) than in the non-OP group (50.23±10.08) ( t=10.26, P<0.001). There was no significant difference in the levels of Ca, P, β-CTX, PINP, or N-MID between the two groups (all P>0.05). The levels of BAP (13.25±3.12) and OC (6.62±1.24) in the OP group were significantly lower than those in the non-OP group (BAP: 18.23±3.78, t=5.52, P<0.001; OC: 8.75±1.52, t=5.87, P<0.001). Pearson correlation analysis showed a positive correlation between 25 (OH) D level and bone density, BAP, and OC ( r=0.26, 0.21, 0.23, all P<0.05), while IL-6 level showed a negative correlation with bone density, BAP, and OC ( r=-0.39, -0.21, -0.27, all P<0.05). ROC curve analysis showed that serum 25 (OH) D and IL-6 could serve as effective diagnostic markers for GDM complicated with OP (AUC=0.853, P<0.0001; AUC=0.869, P<0.0001) during early pregnancy. Conclusions:The serum 25 (OH) D level is decreased and IL-6 level is increased in GDM patients with OP during early pregnancy. The levels of serum 25 (OH) D and IL-6 have predictive value for the development of GDM complicated with OP during early pregnancy.