No abstract available.
Adenomatous Polyposis Coli*

No abstract available.

No abstract available.
Cell Line* ; Colorectal Neoplasms* ; Eflornithine* ; Humans*

No abstract available.
Stomach Neoplasms*

No abstract available.
Carcinoma, Hepatocellular* ; Cell Line* ; Hepatoblastoma* ; Humans*

No abstract available.
Carcinoma, Renal Cell* ; Cell Line* ; Humans*

No abstract available.
Cell Line* ; Dimethyl Sulfoxide* ; Intercellular Signaling Peptides and Proteins* ; Thyroid Gland* ; Thyroid Neoplasms*

PURPOSE: The criteria for Suspected hereditary nonpolyposis colorectal cancer(Suspected HNPCC) has been devised by the Korean Hereditary Tumor Registry for families who do not fulfill Amsterdam criteria, but hereditary background is strongly suggested. This study was performed to define the clinical characteristics of 'Suspected HNPCC'. METHODS: The 'Suspected HNPCC' criteria include the followings: a) vertical transmission of colorectal cancer or at least two siblings affected with colorectal cancer in a family and b) development of multiple colorectal tumors (including adenoma) or at least one colorectal cancer case diagnosed before the age of 50 years or development of extracolonic cancers (endometrium, urinary tract, small intestine, stomach, hepatobiliary system, ovary) in family members. We analysed the clinical characteristics of 93 patients from 39 Suspected HNPCC families and compared these characteristics with 176 HNPCC familes and with 1,204 non-hereditary colorectal cancer patients. RESULTS: The mean age of Suspected HNPCC patients at the time of diagnosis (49.0 years) was significantly lower than that of non-hereditary colorectal cancer patients (56.1 years), but higher than that of the HNPCC patients (44.5 years). Tumors were more frequently located in the right colon (34%) in Suspected HNPCC compared to non-hereditary colorectal cancer (23%). Dukes' A and B cancers were more frequent in the Suspected HNPCC as compared to non-hereditary colorectal cancer (55% vs. 48%, p<0.05), but tumor differentiation was not statistically different between the two groups. Among the Suspected HNPCC, 24.0% of the patients had synchronous adenomatous polyps and 20.0% had synchronous colorectal cancers and 15.6% had metachronous polyps or cancers. These findings were similar to HNPCC, but significantly higher than non-hereditary colorectal cancers (p<0.05). In Suspected HNPCC families, 42 patients had extracolonic malignancies with the stomach cancer being the most common (n=22). CONCLUSION: These data indicate that the clinical characteristics of Suspected HNPCC are similar to those of HNPCC and may suggest that the management principles of the HNPCC should also be applied to the Suspected HNPCC.
Adenomatous Polyps ; Colon ; Colorectal Neoplasms ; Diagnosis ; Humans ; Intestine, Small ; Korea* ; Polyps ; Siblings ; Stomach ; Stomach Neoplasms ; Urinary Tract

The surgical options for ulcerative colitis have developed rapidly in recent years, with emphasis on improving the quality of life by preservation of voluntary defecation and continence while eradicating the disease. In this paper, we have retrospectively analyzed 29 patients with pathologically proven ulcerative colitis who underwent surgical treatment at the Department of Surgery, Seoul National University Hospital between 1980 and 1996. We sought to correlate the changing patterns of the surgical management with their outcomes. The mean age at the time of definitive surgical procedures was 36.7(+/-11.9), and median duration of follow-up was 26 months. The final surgical procedures performed in these patients were ileal J pouch-anal anastomosis (14), total proctocolectomy with either end (7) or continent ileostomy (4), total colectomy with ileorectal anastomosis (1) or Hartmann procedure (2), and partial colectomy (1). Since 1993, we have been performing ileal pouch-anal anastomosis(IPAA), which was performed in all patients except two (one with toxic colitis and the other with disseminated colon cancer). In two patients who underwent partial colectomy and were available for follow-up, there was recurrence of symptoms related to ulcerative colitis. All 11 patients who received total proctocolectomy with either end or continent ileostomy experienced at least one postoperative complication, and 5 required reoperations for management of these complications. Tn particular, 3 out of 7 patients who received total proctocolectomy with continent ileosotmy required removal of the pouch due to pouch related complications. There were two postoperative deaths due to septic complications. On the other hand, while 8 out of 14 patients who received IPAA experienced postoperative complications, all were resolved with conservative management and none required reoperation. The function of ileal J pouch was assessed in 13 Patients at a median duration of 10 months (range : 3~27 months) after restoration of pouch continuity. The mean stool frequency per 24h was 7.6(+/-2.1) and mean nocturnal stool frequency was 1.6(+/-1.5). None of the patients had major incontinence while 7 had occasional spotting of mucous. The remaining 6 patients had normal continence. Only one patient needed antidiarrheal medication and 5 followed a strict diet. Confirmed pouchitis occurred in only one patient. All of the patients who received IPAA were satisfied with their bowel status and the operation. Our results confirm that IPAA is an acceptable surgical option for the management of ulcerative colitis.
Colectomy ; Colitis ; Colitis, Ulcerative* ; Colon ; Colonic Pouches ; Defecation ; Diet ; Female ; Follow-Up Studies ; Hand ; Humans ; Ileostomy ; Metrorrhagia ; Postoperative Complications ; Pouchitis ; Quality of Life ; Recurrence ; Reoperation ; Retrospective Studies ; Seoul ; Ulcer*

Local excision for rectal cancer can yield comparable results to traditional radical operations in selected group of patients. We have retrospectively analyzed 32 cases of rectal cancer patients treated by transanal local excision for curative intent at the Department of Surgery, Seoul National University Hospital between 1990 to 1996. These 32 cases represent 4.1% of total rectal cancer patients treated during the same period. Mean age of the patients were 57.0+/-11.8 years. Median tumor size was 2 cm(mean : 2.4+/-1.1 cm), and the median distance from the anal verge to the lower margin of the tumors was 5 cm(mean : 5.1+/-1.7 cm). Deepest layer invaded by cancer was as follows: mucosa, 31.3%; submucosa, 56.3%; muscularis propria, 9.4%; subserosa, 3.1%. Sixty-nine percent of the patients had well differentiated tumors and 31% had moderately differentiated tumors, while none of the cancers were poorly differentiated. No patient received any adjuvant therapy. After a median follow-up of 21 (range: 1~83) months, no local recurrence occurred in any of the patients. Our results indicate that transanal local excision can be performed with favorable outcome in selected group of rectal cancer patients.
Follow-Up Studies ; Humans ; Mucous Membrane ; Rectal Neoplasms* ; Recurrence ; Retrospective Studies ; Seoul